Cholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution

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dc.contributor.authorOdabaşı, Mehmet
dc.contributor.authorUzun, Lokman
dc.contributor.authorBaydemir, Gözde
dc.contributor.authorAksoy, Neşe Hayat
dc.contributor.authorAcet, Ömür
dc.contributor.authorErdönmez, Demet
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:14:52Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:14:52Z
dc.date.issued2018
dc.departmentFen-Edebiyat Fakültesi Veteriner Fakültesi
dc.description.abstractMolecularly imprinted polymers which have been extensively investigated as selective adsorbents were constructed using a template molecule during the polymerization to gain template-specific cavities. In this study, we prepared cholesterol imprinted poly(2-hydroxyethyl methacrylate-methacryloyamidotryptophan) (PHEMA-MTrp) particles embedded composite membranes. These membranes were characterized through elemental analysis, FTIR, SEM, swelling tests, and surface area measurements. Adsorption experiments were performed in a batch experimental set-up, and the adsorption medium was either a methanol or intestinal-mimicking solution. Stigmasterol and estradiol were used as competing molecules in selectivity tests. Some results are as follows: the specific surface areas of MIP particle-embedded membranes, NIP particle-embedded membranes, and membranes without particles were 36.5, 29.2 and 13.7 m(2)/g, respectively. The imprinted membranes were 1.96 and 2.13 times more selective for cholesterol when compared to stigmasterol and estradiol used as competitor agents, respectively. Cholesterol adsorption capacity increased up to 23.43 mg/g with increasing cholesterol concentration of 2 mg/mL. The MIP particle-embedded composite membranes showed a negligible loss in cholesterol adsorption capacity after ten consecutive adsorption cycles using the same adsorbent.
dc.identifier.doi10.1016/j.colsurfb.2017.12.033
dc.identifier.endpage274en_US
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid29316524
dc.identifier.scopusqualityQ1
dc.identifier.startpage266en_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2017.12.033
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4183
dc.identifier.volume163en_US
dc.identifier.wosWOS:000427217300031
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMolecularly imprinted polymers (MIP)
dc.subjectParticles Embedding
dc.subjectCholesterol Imprinting
dc.subjectN-methacryloyl-(L)-tryptophan (MTrp)
dc.titleCholesterol imprinted composite membranes for selective cholesterol recognition from intestinal mimicking solution
dc.typeArticle

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