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Öğe Turnover intention, collaboration and competences of intensive care unit nurses: A descriptive correlational study(W.B. Saunders, 2025) Avcı, Miyase; Avcı, Ahmet...Öğe Increasing microplastics pollution: An emerging vector for potentially pathogenic bacteria in the environment(Elsevier Ltd, 2025) Tavşanoğlu, Ülkü Nihan; Akça, Gülçin; Pekmez, Tülay; Başaran Kankılıç, Gökben; Çırak, Tamer; Çağan, Ali Serhan; Özkan Kotiloğlu, Selin; Grossart, Hans-PeterMicroplastics (MP), plastic particles <5 mm, are of global concern due to their worldwide distribution and potential repercussions on ecosystems and human well-being. In this study, MP were collected from the urbanized Susurluk basin in Türkiye to evaluate their vector function for bacterial biofilms, both in the wet and dry seasons. Bacterial biofilms were predominantly found on polyethylene (PE), polypropylene (PP), and polystyrene (PS), which constitute the most common MP types in the region. Specific potentially pathogenic bacterial genera, including Pseudomonas sp., Comamonas sp., Salmonella spp., and Shigella spp., were prevalent on MP surfaces. Notably, PE and PP harboured numerous genera of potential human and/or animal origin such as Staphylococcus, Proteus, Escherichia, Enterococcus, and Enterobacter. Water quality played a pivotal role in bacterial biofilm formation on MP. Higher salinity in estuarine areas reduced bacterial abundance on MP, while the more polluted freshwater Nilüfer Stream harboured a higher abundance of total bacteria, particularly of potentially pathogenic strains. Seasonal variations, ambient water conditions, and polymer type are all factors that could influence bacterial colonization on MPs. This catchment-wide evaluation, which includes various habitat types (lentic and lotic systems), the enrichment of cultivable viable bacteria on microplastics (MPs) - a key factor in the spread of pathogens - has significant implications for both environmental and public health. Unlike controlled laboratory experiments or in-situ studies with various particles, this study emphasized the dynamic and complex nature of bacterial strains on MPs, which varied depending on seasonal dynamics and antropogenic impacts in open systems. Further research is needed to thoroughly investigate to fully explore the complex interactions among MPs, microbial communities, and their ecological roles, especially in the context of changing environmental factors across entire river catchments.Öğe Effect of In Vitro Digestion on Anticancer and Antioxidant Activity of Phenolic Extracts From Latex of Fig Fruit (Ficus carica L.)(John Wiley and Sons Inc, 2025) Yeniocak, Salih; Karaduman Yeşildal, Tuğçe; Arslan, Mustafa Enes; Toraman, Gizem Cansu; Yücetepe, AysunIn this study, changes in total phenolic content (TPC), phenolic profile, and antioxidant activity and anticancer activity against cervix cancer and colorectal cancer cell lines of phenolic extracts of black and white fig (Ficus carica L.) latex (milk) were investigated during in vitro gastrointestinal digestions for the first time. The findings indicated that the in vitro digestion process exerted a significant effect on TPC of the phenolic extract from white fig milk (WFM-PE) and phenolic extract from black fig milk (BFM-PE), and TPC tended to decrease after in vitro digestion (p < 0.05). As consistent with these findings, antioxidant activity (by the CUPRAC method) of the samples decreased (p < 0.05) during in vitro digestion. The IC50 value of the undigested BFM-PE was significantly lower than that of the undigested WFM-PE (p < 0.05). The undigested and the digested WFM-PE and BFM-PE did not show any cytotoxic activity against normal cells. However, anticancer activity of WFM-PE on cervix and colorectal cancer cell lines (p < 0.05) and anticancer activity of BFM-PE against colorectal cancer cell lines decreased after in vitro digestion (p < 0.01). On the other hand, the dominant phenolic was catechin hydrate and was syringic acid.Öğe Production and characterization of chitosan-based superhydrophobic film bio-inspired by Verbascum sp. leaf(Elsevier B.V., 2025) Al-jaf, Ivan; Akyüz Yılmaz, Bahar; Karaduman Yeşildal, Tuğçe; Akyüz, Lalehan; Kaya, MuratChitosan, a biodegradable and biocompatible biopolymer, is widely favored in film production as an eco-friendly alternative to petroleum-based films. However, its limited water resistance restricts its applications. To address this issue, the water resistance of chitosan films was enhanced by coating their surfaces with hair derived from the leaves of the Verbascum sp. plant, a species that is abundant and easy to cultivate. Natural superhydrophobic films were successfully produced by embedding needle-like hairs onto the surfaces of chitosan matrices. The resulting films were characterized using standard analytical techniques, including FTIR, TGA, SEM, XRD, elemental analysis, and contact angle measurements. The results indicated that the water contact angle values for the CVH100 and CVH200 films, recorded at 143.01° and 146.83° respectively, exhibited an increase as the quantity of needle-like hairs. However, the contact angle of the chitosan film without needle-like fibrils was 103.44°. Additionally, biocompatibility was confirmed through MTT testing, and blood compatibility was validated via hemolysis assays. These results highlight the potential of these superhydrophobic chitosan films as innovative surface coatings for diverse applications, particularly in the biomedical field.Öğe Thermoplastic Polyurethane-Oleic Acid (TPU-OLE) Membranes for Guided Bone Regeneration(John Wiley and Sons Inc, 2025) Karahaliloğlu, Zeynep; Hazer, BakiGuided bone regeneration (GBR) is a regenerative surgical procedure in dentistry and orthopedics. The aim of this study is to fabricate a novel nano-textured, hydrophilic thermoplastic polyurethane (TPU)-based barrier membrane containing unsaturated fatty acid, oleic acid (OLE) to assist GBR. First, TPU copolymer containing OLE in different ratios was synthesized, and GBR membranes were fabricated by the solvent casting method, and then, the surface properties were improved by alkali treatment. Thus, a TPU-OLE structure was obtained with improved surface wettability, the ability to prevent bacterial adhesion, and the capability to promote cell adhesion. The contact angle reduced from 73.3° ± 1° to 30.7° ± 0.3° at TPU-OLE3, while at TPU it decreased from 121.2° ± 2.5° to 63.6° ± 0.8° after treatment with 3 M sodium hydroxide (NaOH) solution. Furthermore, plate counting assays showed that TPU-OLE membranes displayed excellent bacterial inhibition (against Escherichia coli and Staphylococcus aureus); the control group showed 6 × 107 CFU/mL of E. coli bacterial colonies, while on the plates interacting with TPU-OLE1, TPU-OLE2, and TPU-OLE3 membranes, colonies of 12 × 105, 12 × 105, and 24 × 105 CFU/mL were observed, respectively. The bacterial count on TPU-OLE1, TPU-OLE2, and TPU-OLE3 membranes decreased by 109, 164, and 12 × 105 CFU/mL at 24 h, while the control group and TPU membranes showed 1300 × 105 and 600 × 105 CFU/mL, respectively. The obtained results indicated that either alkali treatment or OLE-modified TPU produced a more hydrophilic and promotive surface for cell attachment. Therefore, we anticipate that alkali-treated TPU-OLE membranes have a great potential in GBR in future applications.Öğe Thiol/Disulphide Homeostasis in the Relationship Between Body Condition Score and Oxidative Stress in Periparturient Period Holstein Heifers(John Wiley and Sons Inc, 2025) Kayar, Tamer; Özkurt, Güzin; Erzurum, Onur; Er, Kübra; Büyükgüngör, Beril; Geçgel, Beyza Nur; Karaburç, Muhammet NureddinThis study aimed to evaluate the effects of body condition scores (BCSs) on oxidative stress and thiol/disulphide homeostasis (TDH) in Holstein pregnant heifers during the transition period. A total of 36 healthy primiparous heifers in the 7th month of pregnancy, all approaching their first calving, were included in the study. The animals were allocated into three equal groups based on their BCS. The BCS measurements were performed 21 days pre-calving and on the 21st day post-calving. Pre-calving and post-calving serum levels of total thiol (TTL), native thiol (NTL) and disulphide (DSF) were quantified using standard techniques. The study revealed significant differences in BCS, TTL and DSF values among groups both pre- and post-calving (p < 0.05), whereas the changes in NTL values were statistically insignificant (p > 0.05). Overall, a decrease in BCS and NTL levels was observed, accompanied by an increase in TTL and DSF levels. Correlation analysis within groups indicated low-level relationships between changes in BCS and TTL, NTL and DSF levels. Consequently, regression analysis did not yield any statistically significant predictive models. The results showed a differential response between the loss of BCS and the oxidative stress during the periparturient period. The increased DSF levels observed during late pregnancy and early lactation indicate a deficiency in antioxidant substances in the animals. Therefore, supplementing the ration with a premix containing antioxidant substances during the transition period may provide significant benefits in terms of maintaining the BCS balance, animal welfare and herd health.Öğe Investigation of the Correlation Between ELISA and Serum Amyloid A in the Diagnosis of Bordetella bronchiseptica in Dogs(John Wiley and Sons Inc, 2025) Sanioğlu Gölen, Gökçenur; Akar, Kadir; Ekin, İsmail HakkıBackground: Bordetella bronchiseptica is an essential bacterial pathogen characterized by chronic respiratory disease in dogs known as Kennel cough. The presence of causative antibodies in animals can also be detected by lipopolysaccharide antigen-based enzyme linked immunosorbent assay (ELISA). In recent years, it has been determined that there is a significant relationship between acute phase proteins and diseases, and disease follow-up can be done within the framework of this relationship. Methods: In this study, blood sera from 150 dogs in an animal shelter in Van province were evaluated for B. bronchiseptica by the homemade ELISA method, and their correlations with serum amyloid A (SAA) were investigated. Blood serum samples were analysed for antibodies against B. bronchiseptica using a homemade ELISA method. Positive animals were also molecularly confirmed using nasal swabs by PCR. A commercial ELISA kit determined SAA levels in blood sera. Results: Eighteen (12%) of the analysed blood serum samples were found positive by the homemade ELISA method. SAA concentrations in the positive blood sera were elevated from 12.7 to ≤38.98 mg/L. SAA concentrations in blood sera serologically positive for B. bronchiseptica were statistically significant. Conclusions: In this study, in which the relationship between SAA concentration and B. bronchiseptica was investigated for the first time in Turkey, it was concluded that SAA concentration analysis may help diagnose and monitor the disease. In addition, the presence and prevalence of this critical and zoonotic agent causing chronic respiratory tract disease in dogs in Van province was revealed for the first time in this study.Öğe Innovative and cost-effective approaches to enhance nutrient removal and energy efficiency in conventional wastewater treatment plants(Academic Press, 2025) Alver, Alper; Küçükbayrak, MustafaThe 42 Evler Wastewater Treatment Plant (WWTP), originally operated as a conventional activated sludge (CAS) system, was transformed into an advanced biological system using the Modified Ludzack-Ettinger (MLE) process scheme, significantly improving nutrient removal and energy efficiency. Integrating anoxic-aerobic zones and optimizing microbial dynamics enhanced treatment performance, with total nitrogen (TN) and total phosphorus (TP) removal efficiencies increasing from 28.1 % to over 80 % and from 56.4 % to 89.6 %, respectively. These improvements were achieved alongside a 32.9 % reduction in energy consumption. Detailed microbial analyses identified key new species, such as Nitrosomonas and Thiobacillus, whose roles in nitrification and denitrification pathways were pivotal for improving treatment performance. Integrating anoxic-aerobic zones, advanced aeration systems, and optimized sludge management further contributed to the system's sustainability. Evaluating pollutant removal efficiencies before and after the upgrade, supported by statistical analyses, confirmed significant improvements in BOD5, COD, TN, TP, and TSS removal. The microbial community was comprehensively assessed, revealing the specific roles of microorganisms in nutrient removal and process optimization. These advancements align with stringent discharge standards and global environmental goals, demonstrating how microbial insights and process innovations can modernize wastewater treatment. The upgraded system provides a scalable and efficient framework for addressing environmental and operational challenges in wastewater management.Öğe Hypericum scabrum L.-infused locust bean gum/agar hydrogel film: A novel candidate for anti-aging facial mask applications(Elsevier B.V., 2025) Boran Gülen, RukiyeThis study investigated the anti-aging potential of Hypericum scabrum L. extract and developed a biopolymer-based hydrogel film designed for use as a facial mask. The research evaluated key anti-aging properties, such as the inhibition of collagenase, elastase, and hyaluronidase enzymes, as well as antioxidant activity, and the cytotoxic, genotoxic, and antigenotoxic effects of the extract. Furthermore, the chemical profile of the extract was thoroughly analyzed using LC-MS/MS. The development of a hydrogel film containing locust bean gum (LBG), agar, and glycerol, integrated with H. scabrum extract, was undertaken to provide an innovative and environmentally sustainable solution for skin aging. The structural and functional characteristics of the hydrogel were analyzed using SEM, XRD, FTIR, and TGA/DTA. Additionally, mechanical testing, swelling, weight loss, thickness, in vitro release kinetics, and antibacterial properties were assessed. The H. scabrum extract demonstrated substantial collagenase inhibition, pronounced antioxidant effects, and no genotoxicity, while also exhibiting notable antigenotoxicity (24–69 %). SEM analysis revealed that the unswollen hydrogel had a uniform, smooth surface, while swelling led to a moderately rough texture with pore formation. The hydrogel exhibited rapid swelling (106 ± 1.52 %) and drug release (34.4 ± 0.21 %) within the first 10 min. Thickness and weight loss were within optimal ranges, and the hydrogel exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). These findings suggest that the H. scabrum-infused hydrogel film has the potential to serve as a promising candidate for use as an anti-aging facial mask, offering effective anti-aging benefits in an eco-friendly, biocompatible, and sustainable formulation.Öğe Metaphorical perceptions of nursing students toward sexuality during pregnancy: An example of metaphor analysis(Churchill Livingstone, 2025) Gökşin, İlknur; Yüksel, ArzuBackground: Pregnancy is one of the periods of life in which women's sexuality is negatively affected by the cultural structure of society and false beliefs. Determining the perspectives of nurse candidates on sexuality during pregnancy will contribute to the training of nurses who will be able to evaluate sexuality and provide holistic health care in the future. Objectives: This study aims to describe the metaphorical perceptions of nursing students toward sexuality during pregnancy through metaphors. Design: A metaphor analysis technique based on phenomenological method. Methods: This study was conducted with 317 nursing students in Turkey. The study data were collected with questionnaire form prepared by the researchers between January and February 2024. In the first part of the questionnaire, questions about socio-demographic characteristics were included, and in the second part, the sentence “Sexuality during pregnancy is like., because.” was included to determine the metaphors developed by the students about sexuality during pregnancy. The 317 valid metaphors revealing the students' perceptions of the concept of sexuality during pregnancy were grouped under 3 categories; “Creating danger and causing harm”, “Need/necessity or usual”, and “Unnecessary, wrong or should not be”. Conclusions: In the study, students provided metaphors containing both positive and negative concepts related to sexuality during pregnancy. However, the majority of the metaphors produced contain negative concepts. It is recommended that a sexuality/sexual health course covering sexuality and nursing care in different life periods such as pregnancy be added to the nursing education curriculum in order to determine the perspectives of nursing candidates on pregnancy sexuality, to make them aware of their attitudes and beliefs, and to ensure that they are prepared for the situations they may encounter in health care after graduation.Öğe An ex vivo experimental study comparing the effects of the holmium: yttrium–aluminum-garnet and thulium fiber lasers on testicular tissue(Springer Science and Business Media Deutschland GmbH, 2025) Karaaslan, Mustafa; Yılmaz, Mehmet; Ordu, Melike; Şirin, Mehmet EminThe effects of lasers on testicular tissue have not yet been investigated in detail. In this experimental ex vivo study, we aimed to demonstrate and compare the effects of the holmium:yttrium–aluminum-garnet (Ho:YAG) and thulium fiber laser (TFL) lasers on testicular tissue. An ex vivo experiment was performed using calf testes. A 100W Ho:YAG laser and a 60W TFL devices with a setting spectrum at 10–60W, a frequency of 20–40 Hz, energy levels at 0.5–1–1.5 J, and medium pulse duration were tested. Histopathological parameters such as Incision depth (ID), vaporization area (VA), coagulation area (CA), and total laser area (TLA = VA + CA) were evaluated. In testicular tissue without a tunica layer, a statistically significant difference was found in the mean VA and TLA values between the Ho:YAG and TFL, in favor of Ho:YAG (p = 0.003, p = 0.003, respectively). In testicular tissue with a tunica layer, there was a statistically significant difference in mean VA, CA, TLA, ID values between Ho:YAG and TFL, in favor of Ho:YAG (all p < 0.001). At 1.5 J–20 Hz and 1.5 J–40 Hz, we observed that the features indicating tissue dissection, such as VA and ID, were lower in the TFL than those in Ho:YAG, while CA values were higher. VA, CA, TLA, ID values were significantly increased in tissue with tunica compared to non-tunicated tissue in both the Ho:YAG and TFL applications. At 30W and 60W, the penetrative effect of the TFL on tissue was less than that of the Ho:YAG, but its coagulation property was superior. (Table presented.)Öğe Planned iliohypogastric neurectomy for prevention of chronic pain after inguinal hernia repair(Springer-Verlag Italia s.r.l., 2025) Gemici, Kazım; Özeren, ErsinPurpose: The present study aimed to investigate the effect of planned ilohypogastric neurectomy (IHPN) in preventing chronic postoperative inguinal pain (CPIP) after anterior herniorrhaphy (AH). Materials and methods: This prospective, randomized study was conducted between 2016 and 2023. Emergency and incarcerated hernia cases, bilateral inguinal hernias, cases with complications such as postoperative hematoma infection, cases in which the neuroanatomy of the inguinal region was unintentionally damaged, femoral hernias, and paraplegic patients with loss of sensation who underwent anterior inguinal herniorrhaphy with prolene mesh were excluded, and the remaining 1375 patients were included in this study. The patients were randomized into preoperative control and study groups. After further excluding 247 patients (18%) in whom the IHN could not be identified during the operation, 82% of the 1375 patients (n = 1128) were included in this study. In the control group, the RCA segment of the IHN that would remain under the mesh was preserved (control group = G1 = 534). The second group in which this segment of the RCA was excised comprised the study group (G2 = 594). Two groups were prospectively followed and pain scores (PS) were recorded regularly with a 4-point scale. The average follow-up period was 15 months (range 11–19 months) in G1 and 14 months (range 10–18 months) in G2. Results: The number of patients with CPIP was 68 in G1 and 19 in G2, this difference was found to be statistically significant (p: < 0.001). There were 19 patients in G1 and 41 patients in G2 with loss of sensation in the operation area, and a significant difference was detected in this respect (p = 0.012). Conclusion: The rate of developing CPIP was significantly lower in patients who underwent IHPN during anterior herniorrhaphy than in those who did not undergo IHPN. The subjective nature of the pain sensation complicates measuring and scoring this sensation and methodologically limits the study.Öğe Determination of both the expression and serum levels of epidermal growth factor and transforming growth factor β1 genes in COVID-19(Nature Research, 2025) Yıldız Gülhan, Pınar; Eröz, Recep; Öztürk, Cihadiye Elif; Yekenkurul, Dilek; Altınsoy, Hasan Baki; Güleç Balbay, Ege; Erçelik, Merve; Davran, Fatih; Yıldız, ŞeymaWe aimed to evaluate the effects of both the expression and serum levels of Epidermal growth factor (EGF) and Transforming growth factor-β1 (TGF-β1) genes in patients with different degrees of cellular damage as mild, moderate, severe, and critical illness that can lead to fibrosis caused by SARS-CoV-2. Totally 45 individuals (male: 21(46.67%); female: 24(53.33%)) with COVID-19 infection were included in this study. Four groups were constituted as mild (n = 16)], moderate (n = 10), severe (n = 10), and critical (n = 9) according to the severity of the disease. Blood samples were drawn from the patients, and all of the hemograms, EGF and TGFβ1 gene expression, and serum levels were evaluated. The mean age of individuals was 57.311 ± 18.383 (min: 28, max: 94). Significant differences were found among the groups for PLT (χ2 = 9.955; p = 0.019), CRP (χ2 = 7.693; p = 0.053), Ferritin (χ2 = 22.196; p < 0.001), D-dimer (χ2 = 21.982; p = 0.000), LDH (χ2 = 21.807; p < 0.001) and all these parameters (exclude PLT in severe groups) was increased depending on the severity of the disease. Additionally, significant differences were detected for EGF (χ2 = 29.528; p < 0.001), TGFB1 (χ2 = 28.981; p < 0.001) expression (that increased depending on the disease severity), and EGF (χ2 = 7.84; p = 0.049), TGFB1 (χ2 = 17.451; p = 0.001) serum concentration levels (that decreased depending on the disease severity). This study found statistically significant differences for both EGF 2−ΔΔCt. TGFβ1 2−ΔΔCt and EGF, TGFβ1 serum concentration values among all patient groups. As disease severity increased, EGF 2−ΔΔCt. TGFβ1 2−ΔΔCt levels increased, while EGF and TGFβ1 serum concentration levels decreased. Perhaps this study will be useful in managing COVID-19 infection severity and pulmonary fibrosis cases secondary to COVID-19.Öğe Exploring the polygenic landscape of wool traits in Turkish Merinos through multi-locus GWAS approaches: middle Anatolian Merino(Nature Research, 2025) Yaman, Yalçın; Önaldı, A. Taner; Doğan, Şükrü; Kırbaş, Mesut; Behrem, SedatThis study investigates the genetic underpinnings of wool traits, specifically fibre diameter (FD) and staple length (SL), in Middle Anatolian Merino sheep using multi-locus genome-wide association study (GWAS) approaches. Representing the first attempt to examine these polygenic traits with multi-locus methods, the analysis employed four techniques: mrMLM, FASTmrMLM, FASTmrEMMA, and ISIS EM-BLASSO. A total of 18 Quantitative Trait Nucleotides (QTNs) were identified for FD, with 7 co-detected by multiple methods, and 14 QTNs were identified for SL, with 5 co-detected by multiple methods. Post-hoc power analysis revealed high statistical power for both traits (FD: 0.95, SL: 0.91). Notably, three candidate genes—PTPN3, TCF4, and ZBTB8A—were found to be consistent with prior studies. Gene enrichment and pathway analyses reaffirmed the complex and multifactorial molecular mechanisms governing wool traits. These findings enhance our understanding of the polygenic nature of wool traits, shedding light on the intricate genetic regulation and pinpointing genomic regions potentially influencing wool physiology. By identifying specific QTNs associated with FD and SL, this research provides a foundation for elucidating the genetic mechanisms underlying these economically significant traits. Upon validation in diverse populations, these findings hold substantial promise for the application of marker-assisted selection (MAS) to improve wool traits.Öğe Enhancing proteasome activity by NMDAR antagonists explains their therapeutic effect in neurodegenerative and mental diseases(Nature Research, 2025) Şahin, Fikret; Günel, Aslıhan; Atasoy, Buse Türegün; Güler, Ülkü; Salih, Bekir; Kuzu, Işınsu; Taşpınar, Mehmet; Çınar, Özgür; Kahveci, SeldaNMDAR antagonists, such as memantine and ketamine, have shown efficacy in treating neurodegenerative diseases and major depression. The mechanism by which these drugs correct the aforementioned diseases is still unknown. Our study reveals that these antagonists significantly enhance 20S proteasome activity, crucial for degrading intrinsically disordered, oxidatively damaged, or misfolded proteins, factors pivotal in neurodegenerative diseases like Alzheimer’s and Parkinson’s. In our mouse model experiment, ketamine administration notably altered brain synaptic protein profiles within two hours, significantly downregulating proteins strongly associated with Alzheimer’s and Parkinson’s diseases. Furthermore, the altered proteins exhibited enrichment in terms related to plasticity and potentiation, including retrograde endocannabinoid signaling—a pivotal pathway in both short- and long-term plasticity that may elucidate the long-lasting effects of ketamine in major depression. Via the ubiquitin-independent 20S proteasome pathway (UIPS), these drugs maintain cellular protein homeostasis, which is crucial as proteasome activity declines with age, leading to protein aggregation and disease symptoms. Therefore, these findings hold promise for new treatment options not only for brain diseases but also for other systemic conditions associated with unfolded or misfolded proteins.Öğe Analyzing the impact of prolonged pauses on soccer performance(Nature Research, 2025) Atıcı, Ali Rıza; Kamış, Okan; Edriss, Saeid; Peker, Coşkun; Bonaiuto, Vincenzo; Bowman, Thomas G.; Nobari, HadiDuring breaks or playing period changes, players’ accumulated workload, physiological alterations, body composition factors, sleep, and health-related qualities can factor into soccer performance. This research examined the impact of prolonged pauses, including breaks due to the 2022 FIFA World Cup and an earthquake tragedy, on running displacements and ball in-play duration during the 2022/23 Turkish Super League season. The secondary purpose was to determine the relationship between performance metrics and competition outcomes (i.e., wins, losses, or draws). 550 players from 19 Turkish Super League teams were included. Performance metrics such as running speed, accelerations/number of speed actions, total field coverage, and match outcomes (i.e., win, lose, or draw) were analyzed before and after significant pauses in play. We also explored correlations between running speed, number of speed actions, match duration, and total distance covered to understand their influence on soccer performance. Significant differences existed in performance metrics between periods, with higher total displacement and running observed after the World Cup (p < 0.05). Additionally, teams exhibiting more static behavior during matches were likelier to lose points, while those running at higher speeds (p = 0.007) and acceleration (p = 0.008) had a higher winning probability. The findings provide valuable insights into the factors affecting success or failure in soccer matches and have implications for training and preparation strategies in professional soccer. In addition, findings illustrate how breaks influence performance metrics and highlight the challenges coaches face in maintaining player readiness during unplanned pauses. This suggests minimizing such disruptions to support optimal training and preparation strategies in professional soccer.Öğe Bond strength of conventional resin-based adhesive cement and self-adhesive resin cement to CAD-CAM restorative materials2025(BioMed Central Ltd, 2025) Şenol, Murat; Gürbüz, Ayhan; Gürbüz, Ayhanurpose: The aim of this study was to compare the shear bond strengths of four distinct CAD/CAM restorative materials using conventional resin-based adhesive cement and self-adhesive resin cement. Materials and methods: Specimens (14 mm × 18 mm × 2 mm) were obtained for each restorative material: IPS e.max CAD (Ivoclar Vivadent (LEICHTENSTEIN), GC Cerasmart (GC-Corp. JAPAN), Vita-Enamic (Vita-ZahnFabrik, GERMANY), and Cerec Blocks (Dentsply Sirona, USA) (n = 12). Ceramic surfaces were applided with both conventional resin-based adhesive cement (LF) (GC-LinkFORCE, GC Corp., JAPAN) and self-adhesive resin cements (CO) (G-Cem One, GC Corp., JAPAN). The shear bond strength test of 96 specimens were calculated and other 96 specimens were measured this test following thermal cycles (10000 thermal cycles at 5–55 oC (SD Mechatronik THERMOCYCLR, Gmbh). Shear bond strength results were statistically analyzed by independent samples t test, one-way ANOVA, two-way ANOVA, four-way ANOVA and for one and all test Post Hoc Tukey HSD test. Results: After thermal cycles, a significant difference was observed between the shear bond strength of LF and CO cements to all ceramics except IPS e.max CAD ceramic (p < 0.05). After thermal cycling, LF cement had the strongest shear bond strength values with GC Cerasmart and the weakest bond values with Vita Enamic. CO cement had the strongest shear bond values with Cerec Blocks ceramics and the weakest bond values with GC Cerasmart. Cohesive type fractures were the most prevalent and adhesive type fractures were the least frequent both before and after thermal cycle. The type of material had a significant effect on the type of fracture after thermal cycle application (p < 0.05). Conclusions: Thermal cycle application caused a decrease in the shear bond strength values of two kind of resin cements to all ceramics. It can be concluded that self-adhesive composite resin cement (G-CemONE) are suitable for leucite-reinforced glass-ceramic and lithium disilicate ceramics, and conventional resin-based adhesive cement (GC-LinkFORCE) is suitable for resin nanoceramic material and polymer-infiltrated glass-ceramic material types.Öğe ChatGPT's ECG interpretations: Sensitivity or specificity? Which matters more in the emergency department(W.B. Saunders, 2025) Sert, Ekrem Taha; Akay, MuhammedWe read with great interest the article by Zaboli et al. [1], titled “Exploring ChatGPT's potential in ECG interpretation and outcome prediction in the emergency department.” This study provides valuable insights into a critical issue in emergency medicine, where both high patient volumes and the potential consequences of misdiagnoses demand precise and efficient decision-making. By exploring the potential role of ChatGPT, the study contributes significantly to the ongoing dialogue on leveraging artificial intelligence (AI) to enhance diagnostic accuracy and streamline workflows in emergency settings.Öğe Response to commentary on: ChatGPT-4o's performance on pediatric vesicoureteral reflux(Elsevier Ltd, 2025) Akyol Önder, Esra Nagehan; Ensari, Esra; Ertan, PelinThe current study evaluated the reliability and readability of ChatGPT-4o’s responses regarding pediatric vesicoureteral reflux [1]. The sources of information have been rapidly evolving, with AI and chatbots, such as ChatGPT, emerging as significant contributors. The scope of artificial intelligence (AI) usage has been expanding in the medical field. However, further research and validation by researchers and healthcare professionals are required before AI can be widely used as a reliable public source of information.Öğe Evaluating Artificial Intelligence Competency in Education: Performance evaluation of ChatGPT in the neonatal resuscitation program exam(Elsevier Ireland Ltd, 2025) Demirtaş, Mehmet Semih; Kokulu, Kamil; Tunç, GaffariArtificial intelligence (AI) applications are increasingly used in the healthcare field and, in addition to their potential benefits, they also bring with them important questions such as accuracy, ethics, security and implementation difficulties.1,2 In addition to the widespread use of social media such as YouTube® and TikTok® among clinicians and healthcare professionals, especially for education and patient care, the use of AI applications has also been increasing in the last 5 years.2,3 In our study, we evaluated the success of ChatGPT, one of the large language models (LLMs), in the neonatal resuscitation program (NRP) with a total of 50 multiple choice questions.4,5 . This can be seen as a step towards understanding the potential role of AI in clinical education and assessment processes.
