PubMed İndeksli Yayınlar Koleksiyonu
Bu koleksiyon için kalıcı URI
Güncel Gönderiler
Öğe Enhancing the performance of unitized regenerative proton exchange membrane fuel cells through microwave-synthesized chitosan based nanocomposites(Elsevier, 2024) Yelegen, Nebi; Kümük, Berre; Balun Kayan, Didem; Baran, Talat; Kaplan, YükselThe membrane electrode assembly (MEA) is a core component of unitized regenerative proton exchange membrane fuel cells (UR-PEMFCs). The studies aimed to improve the cell performance and reduce the cost of the MEAs for the widespread adoption of UR-PEMFCs. The present study focuses on modifications of MEA. For this purpose, an innovative nanocomposite electrocatalyst was developed by using a carbon-based support material containing platinum nanoparticles with a diameter of approximately 20–30?nm via microwave synthesis technique. The electrocatalyst was developed by a single-step process, consist of multi-walled carbon nanotubes (MWCNT), graphitic carbon nitride (g-C3N4), chitosan (Chi), and platinum nanoparticles (MWCNT/g-C3N4/Chi/Pt nanocomposite). With the development of this support material, a relatively economical and effective electrocatalyst was obtained by large surface area and using the platinum on this surface at the nano level. The prepared catalyst was applied to commercially available membrane electrode assemblies with an active area of 100?cm2. Single-cell and triple-stack performance tests were conducted, and an increase of 17.13?% in the electrolyzer mode and 16.98?% in the fuel cell mode was achieved in single-cell performance with this applied electrocatalyst. Furthermore, an enhancement of 16.96?% in the electrolyzer mode and 16.81?% in the fuel cell mode was discerned in the UR-PEMFC stack. Beside the experimental studies, a numerical model of the modified membrane properties has been developed and validated through experimental data.Öğe Predictors of acute kidney injury in chronic kidney disease patients treated for cardiovascular disease in the cardiac intensive care unit (MORCOR-TURK subgroup analysis)(Springer Nature, 2024) Doğan, Ömer; Taşdelen Acar, Aybüke Gül; Gül, Mural; Şafak, Özgen; Ömur, Sefa Erdi; Atıcı, Adem; Barman, Hasan Ali; Cengil, Muhammed Erkam; Yılmaz, Ahmet Şeyda; Ersoy, İbrahimBackground: Acute kidney injury (AKI) is a common complication in chronic kidney disease (CKD) patients in the cardiac intensive care unit (cardiac ICU). In this study, we aimed to identify predictors of AKI in CKD patients treated in the cardiac ICU for cardiovascular diseases. Methods: The MORCOR-TURK trial was conducted as a multicenter, prospective, cross-sectional, and noninterventional investigation. A total of 3157 patients treated in the cardiac ICU were enrolled from 50 centers over the course of one month. In this subgroup analysis, 615 patients with CKD treated in the cardiac ICU for cardiovascular disease were included in the study. The primary outcome of this study was the development of AKI. During hospitalization, patients who developed AKI were identified. Results: AKI developed in 288 patients (46%). After multivariable analysis, decompensated heart failure (OR: 3.72, p = 0.005), primary percutaneous coronary intervention (OR: 3.75, p = 0.004), non-primary percutaneous coronary intervention (OR: 2.85, p = 0.033), troponin levels (OR: 1.04, p = 0.031), and need for mechanical ventilation (OR: 3.11, p < 0.001) were identified as independent predictors of AKI development in CKD patients. Conclusion: Our efforts to identify AKI predictors in cardiac ICU patients with CKD have yielded directly applicable results in clinical practice. AKI can be prevented by developing personalized strategies to follow up and treat cardiac ICU patients with CKD who have decompensated heart failure, are undergoing percutaneous coronary intervention (primary and non-primary), have high troponin levels, and need mechanical ventilation.Öğe Impact of limb occlusion pressure assessment position on performance, cardiovascular, and perceptual responses in blood flow restricted low-load resistance exercise: A randomized crossover trial(Taylor & Francis, 2024) Kamış, Okan; Rolnick, Nicholas; de Queiros, Victor S; Akçay, Neslihan; Keskin, Kadir; Yıldız, Kerem Can; Werner, Tim; Hughes, Luke; Sofuoğlu, CemThis study investigated the effect of limb occlusion pressure (LOP) position on exercise performance, cardiovascular responses, and perceptual experiences during seated bilateral leg extensions with and without blood flow restriction (BFR). Thirty resistance-trained males (age: 22?±?2?years; weight: 74.4?±?13.6?kg; height: 177.4?±?6.4?cm; BMI: 23.5?±?3.3?kg/m2) participated. Each performed exercise to failure (4 sets, 30% 1RM, 1?min rest) in three conditions: Supine LOP-BFR, Seated LOP-BFR, and no-BFR. BFR was applied at 60% LOP. Significant interaction effects were found for RPE (p?=?0.021, d?=?0.76), RPD (p?Öğe Overcoming barriers to cervical cancer prevention in Afghanistan: The imperative for an HPV vaccination and screening program(John Wiley and Sons Ltd, 2024) Sadat, Rowaida; Saçıntı, Koray Görkem; Topçu, Elif Göknur; Saeed, SaeedaThe critical situation of cervical cancer screening and human papillomavirus (HPV) vaccination in Afghanistan demands urgent attention, especially in view of the ongoing political unrest and humanitarian challenges faced by the country. Recent data underscore the urgent need for immediate action to address this pressing issue.Öğe Assessing Algerian Ilex aquifolium L.’s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer’s, diabetes and skin diseases(Taylor & Francis, 2024) Hadroug, Aldjia; Zengin, Gökhan; Belhattab, Rachid; Çakmak, Yavuz SelimThis research explored the impact of methanolic extracts from the fruits and leaves of Ilex aquifolium L., a rare Algerian species, on several enzymes, focusing on tyrosinase, ?-amylase, ?-glucosidase, and cholinesterases, as well as their antioxidant potential in vitro assays, including phosphomolybdenum, DPPH, ABTS, CUPRAC, FRAP, and MCA. HPLC-DAD analysis identified chlorogenic acid, rosmarinic acid, hesperidin, and quercetin as predominant phenolic components. Both extracts exhibited notable antioxidant properties, up to 250.08?mg TE/g for fruits and 237.08?mg TE/g for leaf extracts. Enzyme inhibitory assays demonstrated significant inhibition against AChE and BChE with maximum activities of 2.34?mg GALAE/g in leaves and 4.32?mg GALAE/g in fruits. Additionally, considerable tyrosinase inhibition was observed in leaves at 39.69?mg KAE/g. These findings highlight I. aquifolium L. as a valuable source for investigating natural antioxidants and enzyme inhibitors, particularly for possible cosmetics and food additives applications.Öğe Tubal fimbria migration mimicking an endometrial polyp following Iatrogeniterine perforation(Elsevier, 2024) Bilir, Esra; Eryılmaz, Ahmet İlker; Saçıntı, Koray GörkemA 26-year-old woman, gravida 3, para 2, presented to our clinic with irregular groin pain and vaginal bleeding. Her obstetric history includes a missed abortion for which she underwent dilation and curettage (D&C) two years ago. Her symptoms began three months following this procedure. Her medical history was otherwise unremarkable. A transvaginal ultrasound (TVUSG) revealed a suspected endometrial polyp, located near the uterine fundus. During the operative hysteroscopy, we identified a highly vascularized structure with small finger-like projections filling almost the entire endometrial cavity, which did not resemble a typical endometrial polyp (Figure 1). We performed complete resection of this structure using a 27 Fr bipolar resectoscope with a 2.5mm cutting loop. At the end of the procedure, we detected a uterine perforation (UP) but otherwise observed an unremarkable uterine cavity (Figure 2). Subsequently, we performed a simultaneous diagnostic laparoscopy for exploration and to diagnose the condition encountered. The laparoscopy revealed a normal right fallopian tube. However, the left fallopian tube lacked fimbriae, and there was a perforation at the uterine fundus towards the left side. We mobilized the left fallopian tube, confirming the presence of the left fimbriae within the endometrial cavityÖğe Ovarian tissue cryopreservation and transplantation as a natural means to delay menopause(Springer Science and Business Media Deutschland GmbH, 2024) Saçıntı, Koray Görkem; Sadat, Rowaida; Özkavukçu, Sinan; Sönmezer, MeltemOvarian tissue cryopreservation and transplantation (OTCT) offers hope for preserving fertility and endocrine functions in patients undergoing gonadotoxic treatments. Advancements in techniques for the procedure have transformed OTCT from an experimental procedure into a viable option. There is a growing interest in utilizing OTCT to delay menopause and alleviate associated health issues. Menopausal transition affects women globally, leading to symptoms and long- term health risks. OTCT has the potential to restore endocrine functions, reducing menopause-related symptoms while mitigating health consequences such as osteoporosis and cardiovascular diseases. Although the use of OTCT for delaying menopause is not clinically proven, the discussion around shows potential for future utilization. In essence, the remarkable advancements in OTCT have bestowed upon us the ability to safeguard fertility and sustain the delicate endocrine functions of the ovaries. However, it is the tantalizing prospect of utilizing this technique to postpone menopause and alleviate its associated symptoms that truly captivates the imagination. Further research is imperative to substantiate the clinical efficacy of OTCT; nonetheless, its potential in menopausal therapy is both promising and warrants comprehensive exploration. This review highlights advancements and the feasibility of OTCT to postpone menopause as an alternative approach to currently used conventional menopause therapy methods.Öğe Unveiling genetic diversity among bacterial isolates suing SCoT markers(Springer, 2024) Tekin, Fatih; Altın, İrem; Aydın, Furkan; Alkan, Mehtap; Orel, Didem Canik; Ardıç, Mustafa; Gaši?, Katarina; Kovács, Tamás; Allen, Caitilyn; Özer, GökselThis study aimed to unveil the genetic diversity among 47 bacterial isolates from various species using start codon targeted (SCoT) markers. Six SCoT primers yielded 219 reproducible bands, with 89.04% exhibiting polymorphism. The amplification process generated 28 to 50 fragments per primer, with an average of 36.50. Genetic diversity was quantified using polymorphic information content (PIC) values ranging from 0.11 to 0.14, with SCoT32 showing the highest PIC (0.14) and SCoT23 the lowest (0.11). The resolving power (RP) index, used to assess primer discriminatory power, varied significantly, with SCoT23 demonstrating the highest RP (6.00) and SCoT29 the lowest (4.51). Comparative analysis with conventional markers like M13 and (GTG)5 revealed that certain SCoT primers exhibited superior PIC values, which indicates enhanced utility for interspecies differentiation. The high discrimination level achieved by SCoT primers underscores their effectiveness in genetic differentiation and biodiversity assessment within bacterial populations. This research highlights SCoT markers as powerful tools for microbial genetic studies, which offers valuable insights into bacterial diversity and provides a robust methodological framework for future investigations aimed at elucidating genetic variation and improving species identification. The application of SCoT markers represents a significant advancement in molecular techniques for bacterial characterization and phylogenetic analysis, demonstrating their potential to enhance our understanding of microbial genetics and evolution.Öğe Effects of different pre-exercise strategies on jumping performance in female volleyball players(Edizioni Minerva Medica, 2024) Keskin, Kadir; Akçay, Neslihan; Özmen, Tarık; Contarlı, Nurcan; Yıldız, Kerem C.; Sofuoğlu, Cem; Kamiş, Okan; Rolnick, Nicholas; de Queiros, Victor S.; Montoye, AlexanderThe present study aimed to compare different pre-exercise strategies on jumping performance in female volleyball players. METHODS: Fifteen healthy female volleyball players (age=18 +/- 0.6 years; training experience = 7.3 +/- 1.4 years; height = 164.8 +/- 5.4 cm; body mass = 57.2 +/- 8.1 kg) volunteered to participate in the study. Three different pre-exercise conditions (5 repetition maximum knee extension, electromyostimulation [EMS] and ischemic preconditioning [IPC]) were applied to the subjects and compared to a control condition performing a standardized warmup. Subjects performed the squat jump and 15 sec repeated countermovement jumps following a rest period. Measures associated with jumping performance were collected and compared between conditions. Rating of perceived exertion was also collected after each performance test. RESULTS: No pre-exercise condition outperformed a standardized warm-up on inducing improvements in jumping performance and in fact, EMS and IPC conditions resulted in performance decrements compared to control (P<0.05). CONCLUSIONS: We conclude that a standardized warm-up is enough to induce improvements in jumping performance in female volleyball players. Future research should examine alternative strategies alongside standardized warm-up to determine how best to prepare for jumping and related sport-specific tasks in female volleyball players.Öğe In vitro and in vivo effects of commercial and environmental microplastics on Unio delicatus(Springer, 2024) Yüce, Pınar Arslan; Günal, Aysel Çağlan; Erkmen, Belda; Yurdakök Dikmen, Begüm; Çağan, Ali Serhan; Çırak, Tamer; Başaran Kankılıç, Gökben; Seyfe, Melike; Filazi, Ayhan; Tavşanoğlu, Ülkü NihanMicroplastics (MPs) are ubiquitous pollutants in freshwater environments. In this study, freshwater mussels, Unio delicatus, were exposed to both environmental MPs (e-MP) and commercial MPs (c-MP) that include green fluorescent MP (gf-MP), polyethylene (c-PE) and polystyrene (c-PS) at environmental concentrations (5 mg/L and 50 mg/L) over duration of 7 and 30 days. According to in vivo experiment results, both e-MPs and c-MPs induced significant changes in the total hemocyte counts of mussels (p < 0.05). Exposure to high concentrations of e-MPs and c-MPs for 7 days led to decreased cellular glutathione levels in the mussels, while exposure to low concentrations of e-MPs and c-PS for 7 days resulted in increased advanced oxidation protein products (AOPP). Mussels exposed to high concentrations of e-MPs for 30 days exhibited decreases in both glutathione levels and AOPP values. Although no damage was observed in tissues other than gills and digestive gland, histopathological alterations were observed in these tissues following exposure to 50 mg/L c-MPs. Additionally, MPs were observed in the intestine tissues. In vitro experiments using the MTT assay showed no significant difference in cell viability between the MP-exposed group and the control group at tested concentrations, with no observed dose-response relationship (p > 0.05). Nevertheless, certain cells exhibited signs of cell death, such as disrupted cellular structures, condensed nuclei, and loss of cellular integrity. These observations were consistent with mechanical compression, indicating that physical contact with MPs may result in cell damage or death. These findings demonstrate that environmentally relevant concentrations of MPs have toxic effects on freshwater mussels and multiple parameters provide valuable insight for the evaluation of health risks of organisms.Öğe Computationally derived endosteal strain and strain gradients correlate with increased bone formation in an axially loaded murine tibia model(Elsevier Ltd, 2024) Horasan, Murat; Verner, Kari A.; Yang, Haisheng; Main, Russell P.; Nauman, Eric A.Osteoporosis is a common metabolic bone disorder characterized by low bone mass and microstructural degradation of bone tissue due to a derailed bone remodeling process. A deeper understanding of the mechanobiological phenomena that modulate the bone remodeling response to mechanical loading in a healthy bone is crucial to develop treatments. Rodent models have provided invaluable insight into the mechanobiological mechanisms regulating bone adaptation in response to dynamic mechanic stimuli. This study sheds light on these aspects by means of assessing the mechanical environment of the cortical and cancellous tissue to in vivo dynamic compressive loading within the mouse tibia using microCT-based finite element model in combination with diaphyseal strain gauge measures. Additionally, this work describes the relation between the mid-diaphyseal strains and strain gradients from the finite element analysis and bone formation measures from time-lapse in vivo tibial loading with a fluorochrome-derived histomorphometry analysis. The mouse tibial loading model demonstrated that cancellous strains were lower than those in the midshaft cortical bone. Sensitivity analyses demonstrated that the material property of cortical bone was the most significant model parameter. The computationally-modeled strains and strain gradients correlated significantly to the histologically-measured bone formation thickness at the mid-diaphyseal cross-section of the mouse tibia.Öğe Potential protective effect of hesperidin (Vitamin P) against hlyphosate-induced spermatogenesis damage in male rats: biochemical and histopathological findings on reproductive parameters(MDPI, 2024) Güngör, Şükrü; Kırıkkulak, Murat; Denk, Barış; Gülhan, Mehmet Fuat; Güleş, Özay; Budak, Duygu; İnanç, Muhammed Enes; Avdatek, Fatih; Yeni, Deniz; Taşdemir, UmutThe aim of this study was to investigate the effectiveness of hesperidin (HES) on testicular histopathological changes, biochemical changes, and semen characteristics in rats exposed to glyphosate (GLP). The control group was given a normal diet devoid of GLP and HES, the HES group was given 100 mg/kg/day HES with the normal diet, the GLP group was given GLP at the LD50/10 dose of normal feed, which was 787.85 mg/kg/day, and the GLP + HES group was given normal feed containing 787.85 mg/kg/day LD50/10 dose of GLP in addition to 100 mg/kg/day HES. GLP administration reduced sperm motility, sperm plasma membrane integrity, glutathione levels, and total antioxidant levels in the testicular tissues of rats. Moreover, it caused an increase in right testis and left epididymis weights, abnormal sperm counts, malondialdehyde levels, total oxidant status, and DNA damage. The HES treatment showed curative effects on these parameters. Furthermore, HES was effective in lessening the histopathological damage that was caused by GLP. The results showedthat HES protects spermatological parameters and DNA integrity, improves antioxidant defenses, and lowers the damage and lipid peroxidation caused by GLP in testicular tissue.Öğe Prognostic indicators in patients with isolated thoracic trauma: A retrospective cross-sectional study(Turkish Association of Trauma and Emergency Surgery, 2024) Yazıcı, Ramiz; Bulut, Bensu; Genc, Murat; Akkan Öz, Medine; Hanalıoğlu, Damla; Kokulu, Kamil; Sert, Ekrem Taha; Mutlu, HüseyinThoracic trauma is a significant cause of mortality, especially among those arriving at hospitals. This study explores the associations between mortality, the shock index (SI), and specific metabolic and biochemical markers in patients with isolated thoracic trauma. METHODS: This retrospective cross-sectional study included all consecutive adult patients presenting with isolated thoracic trauma to a high-volume emergency department from January 2019 to December 2023. The predictive capability of SI levels and selected biomarkers upon admission for estimating mortality was assessed by determining the areas under the receiver operating characteristic curves (AUCs). Optimal cutoff values were determined using the Youden index method. RESULTS: The study involved 352 patients, with 285 (81%) being males and an average age of 50.0±17.7 years. The mortality rate was 9.6%. Mortality was significantly associated with higher shock index (odds ratio [OR]: 14.02, [95% confidence interval [CI] 0.8470.916], AUC=0.885, p=0.001), glucose/potassium ratio (OR: 1.24 [95% CI 1.14-1.35], AUC=0.869, p<0.001), and lactate levels (OR: 4.30 [95% CI 2.29-8.07], AUC=0.832, p<0.001). The optimal cutoff values determined for the shock index, glucose/potassium ratio, ionized calcium, and lactate were 1.02 (sensitivity, 94.1%; specificity 69.5%; positive predictive value [PPV], 24.8; negative predictive value [NPV], 99.1), 36.85 (sensitivity, 76.5%; specificity, 87.7%; PPV, 40.0; NPV, 97.2), 1.23 (sensitivity, 94.1%; specificity, 56.0%; PPV, 18.6; NPV, 98.9), and 1.98 (sensitivity, 70.6%; specificity, 80.5%; PPV, 27.9; NPV, 96.2), respectively. CONCLUSION: This study demonstrates that higher shock index, glucose/potassium ratio, and lactate levels are significantly associated with increased mortality in patients with isolated thoracic trauma. These findings suggest that these markers can be effective prognostic indicators, potentially guiding clinical decision-making and improving patient outcomes.Öğe Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers(Beilstein-Institut, 2024) Acet, Ömür; Kirsanov, Pavel; Acet, Burcu Önal; Halets-Bui, Inessa; Shcharbin, Dzmitry; Cömert, Seyda Ceylan; Odabaşı, MehmetNanopolymers represent a significant group of delivery vehicles for hydrophobic drugs. In particular, dual stimuli-responsive smart polymer nanomaterials might be extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex. Thus, doxorubicin-loaded temperature- and pH-sensitive smart nanopolymers (DOX-SNPs) were produced. Characterizations of the synthesized nanostructures were carried out including zeta potential measurements, Fourier-transform infrared spectroscopy, and scanning electron microscopy. The loading capacity of the nanopolymers for DOX was investigated, and encapsulation and release studies were carried out. In a final step, the cytotoxicity of the DOX-nanopolymer complexes against the HeLa cancer cell line at different concentrations and incubation times was studied. The DOX release depended on temperature and pH value of the release medium, with the highest release at pH 6.0 and 41 degrees C. This effect was similar to that observed for the commercial liposomal formulation of doxorubicin Doxil. The obtained results demonstrated that smart nanopolymers can be efficiently used to create new types of doxorubicin-based drugs.Öğe Evaluation of thiol/disulphide and oxidant–antioxidant statusof dairy cows in periparturient and post-partum period(John Wiley and Sons Inc, 2024) Balkan, Burcu Menekşe; Meral, Öğünç; Çetintav, Bekir; Özkurt, Güzin; Sel, TevhideThiol/disulphide homeostasis (TDH) has a critical role in many cellular activities such as antioxidant protection. Alterations of oxidative stress in the transition period play an important role in development of some diseases and disorders in dairy cows. Objectives: The purpose of this study is to assess the total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), total thiol, native thiol, disulphide and lipid profile in Simmental and Montofon dairy cows (aged 2–3) before and after calving. Methods: Blood samples were collected 233–280 days of pregnancy and the 30 days of post-partum. Serum total thiol, native thiol and disulphide levels were determined as well as TAS, TOS and paraoxonase-1 (PON-1) levels were measured using colorimetric assays. Triglycerides (TG), total cholesterol, HDL cholesterol and LDL cholesterol levels were measured with an automatic analyser. Results: Total thiol (p = 0.038) and disulphide (p = 0.015) levels were higher after calving compare to pregnancy in Montofon. TAS was found lower (p < 0.001), and OSI was higher in both breeds (Montofon p = 0.012, Simmental p = 0.028) after calving than in pregnancy. When compared between pregnancy and after calving levels in the same breed, HDL was found to be higher after calving (p < 0.001) and TG was lower after calving (p = 0.020) in Montofon. PON (p = 0.090), HDL (p < 0.001) and cholesterol levels were found higher (p < 0.001) and TG level was lower (p < 0.001) after calving in Simmental. Conclusions: According to our results, we observed different responses between two breeds before and after calving. There are few studies about TDH in animal research, and this is the first study in the literature that evaluates the TDH along with oxidative stress and lipid profiles in dairy cows in the periparturient and post-partum perioÖğe The ameliorative effect of carvacrol on sodium arsenite-induced hepatotoxicity in rats: Possible role of Nrf2/HO-1, RAGE/NLRP3, Bax/Bcl-2/Caspase-3, and Beclin-1 pathways(John Wiley and Sons Inc, 2024) Gencer, Selman; Gür, Cihan; İleritürk, Mustafa; Küçükler, Sefa; Akaras, Nurhan; Şimşek, Hasan; Kandemir, Fatih M.Arsenic is a toxic environmental pollutant heavy metal, and one of its critical target tissues in the body is the liver. Carvacrol is a natural phytocompound that stands out with its antioxidant, anti-inflammatory, and antiapoptotic properties. The current study aims to investigate the protective feature of carvacrol against sodium arsenite-induced liver toxicity. Thirty-five Sprague-Dawley male rats were divided into five groups: Control, Sodium arsenite (SA), CRV, SA + CRV25, and SA + CRV50. Sodium arsenite was administered via oral gavage at a dose of 10 mg/kg for 14 days, and 30 min later, CRV 25 or 50 mg/kg was administered via oral gavage. Oxidative stress, inflammation, apoptosis, autophagy damage pathways parameters, and liver tissue integrity were analyzed using biochemical, molecular, western blot, histological, and immunohistological methods. Carvacrol decreased sodium arsenite-induced oxidative stress by suppressing malondialdehyde levels and increasing superoxide dismutase, catalase, glutathione peroxidase activities, and glutathione levels. Carvacrol reduced inflammation damage by reducing sodium arsenite-induced increased levels of NF-?B and the cytokines (TNF-?, IL-1?, IL-6, RAGE, and NLRP3) it stimulates. Carvacrol also reduced sodium arsenite-induced autophagic (Beclin-1, LC3A, and LC3B) and apoptotic (P53, Apaf-1, Casp-3, Casp-6, Casp-9, and Bax) parameters. Carvacrol preserved sodium arsenite-induced impaired liver tissue structure. Carvacrol alleviated toxic damage by reducing sodium arsenite-induced increases in oxidative stress, inflammation, apoptosis, and autophagic damage parameters in rat liver tissues. Carvacrol was also beneficial in preserving liver tissue integrity.Öğe Evaluating the quality and reliability of YouTube videos on scabies in children: A cross-sectional study(Public Library of Science, 2024) Özdemir Kaçer, Emine; Kaçer, İlaydaRecently, there has been an increase in scabies cases among young children in low- and middle-income countries. With the rise of online health information, platforms such as YouTube have become popular sources of disease-related content, but the accuracy of this information remains a concern. Aim This study evaluates the reliability and quality of YouTube videos concerning scabies in children to address the lack of research in this area. Materials and methods A cross-sectional analysis was conducted on April 1, 2024, reviewing the first 200 relevant YouTube videos with the search terms “scabies” and “scabies in children.” Videos were assessed using modified DISCERN (mDISCERN), Global Quality Score (GQS), and Journal of the American Medical Association (JAMA) scoring systems. Statistical analysis included descriptive statistics, Kruskal-Wallis tests, and Spearman correlation analysis. Results Out of 200 videos, 107 met the inclusion criteria. The average mDISCERN score was 2.17, GQS was 2.63, and JAMA was 2.05, indicating generally poor quality. Videos by patients had the highest quality scores, while those from academic institutions had the highest JAMA scores. Longer videos with higher view counts were associated with better quality. Conclusion This study reveals that the majority of YouTube videos on scabies in children are of low quality. There is a need for healthcare professionals to produce more accurate and reliable content to improve the quality of information available on YouTube. Further research should focus on enhancing the quality of health information on digital platforms.Öğe Structural characteristics of Lacticaseibacillus rhamnosus ACS5 exopolysaccharide in association with its antioxidant and antidiabetic activity in vitro(Elsevier B.V., 2024) İnanan, Tulden; Önal Darılmaz, Derya; Karaduman Yeşildal, Tuğçe; Yavuz, SerkanA novel structure of exopolysaccharide from the Lactic Acid Bacteria (LAB) Lacticaseibacillus rhamnosus ACS5, isolated from home-made Turkish cheese, is described. After lyophilization, the L-EPS-ACS5 was characterized in production and functional activities in vitro, including antioxidant and antidiabetic activities. The physicochemical characterizations of the L-EPS-ACS5 were determined through molecular weight, UV, FTIR, SEM, TGA, HPLC, NMR, methylation, and GC–MS analysis. Strong antioxidant activities of L-EPS-ACS5 were confirmed from the results obtained in the hydroxyl radical, DPPH, ABTS, FRAP, superoxide anion radical, total antioxidant activity, and DNA damage protective effect, and also the L-EPS-ACS5 exhibited high antidiabetic activity (60 %). This study isolated L-EPS-ACS5 from a home-made cheese L. rhamnosus strain, demonstrating its novel and enhanced functionalities compared to existing strains. This opens exciting avenues for its development in the fields of biomedicine and pharmaceuticals.Öğe Can ChatGPT provide quality information about fever in children(John Wiley and Sons Inc, 2024) Özdemir Kaçer, Emine; İpekten, FundaArtificial intelligence (AI) systems hold great promise in improving medical care and health problems. Aim: We aimed to evaluate the answers by asking the most frequently asked questions to ChatGPT for the prediction and treatment of fever, which is a major problem in children. Methods: The 50 questions most frequently asked about fever in children were determined, and we asked them to ChatGPT. We evaluated the responses using the quality and readability scales. Results: While ChatGPT demonstrated good quality in its responses, the readability scale and the Patient Education Material Evaluation Tool (PEMAT) scale used with materials appearing on the site were also found to be successful. Among the scales in which we evaluated ChatGPT responses, a weak positive relationship was found between Gunning Fog (GFOG) and Simple Measure of Gobbledygook (SMOG) scores (r = 0.379) and a significant and positive relationship was found between FGL and SMOG scores (r = 0.899). Conclusion: This study sheds light on the quality and readability of information regarding the presentation of AI tools, such as ChatGPT, regarding fever, a common complaint in children. We determined that the answers to the most frequently asked questions about fire were high-quality, reliable, easy to read and understandable.Öğe An adaptation and validation of disaster resilience scale based on community engagement theory(Wiley, 2024) Gökmenoğlu, Tuba; Daşcı Sönmez, ElifThis study aimed to adapt and validate the Disaster Resilience Scale, originally developed by Becker et al. and revised by Paton et al., for assessing disaster resilience within the Turkish school community with a focus on Community Engagement Theory. This theory emphasizes the role of community involvement in disaster resilience at various levels, including the individual, community, and societal/institutional. The study was conducted in two phases. In the first phase, data from 428 teachers were analyzed to assess the validity and reliability of the scale's Turkish version and its alignment with dimensions. In the second phase, data from 1,422 teachers were used to further verify the reliability of using the Generalizability Theory test, and confirm validity through confirmatory factor analysis. The results confirmed that the Turkish version of the scale, with its 12 factors and 52 items was valid and reliable. Cronbach's Alpha coefficients for the dimensions ranged from 0.80 to 0.91, indicating high reliability. The findings highlight the practical implications of adapting the DRS for enhancing disaster resilience in school communities and underscore the importance of community engagement in disaster preparedness and education.
