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  • Öğe
    C-reactive protein-to-albumin ratio and systemic immune-inflammatory index as potential markers in distinguishing acute cerebellar infarction from benign paroxysmal positional vertigo
    (Riyadh Armed Forces Hospital, 2025) Şahin, Oruç; Güneş, Muzaffer; Dönmez, Recep
    To investigate the potential utility of the C-reactive protein-to-albumin ratio (CAR) and the systemic immune-inflammatory index (SII) as a biomarker in distinguishing between BPPV and acute cerebellar infarction (ACI) due to posterior inferior cerebellar artery (PICA) involvement. METHODS: The data of 2545 patients registered in our hospital database between 2017 and 2024 with a diagnosis of vertigo were retrospectively analyzed and 102 patients with benign paroxysmal positional vertigo (BPPV) and 100 patients with ACI were included in the study. Mann-Whitney U test, Chi-square test, or Fisher's exact test were used to compare variables between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to investigate the predictive value of the data. RESULTS: The CAR and SII values were significantly higher in the ACI group compared to the BPPV group (p<0.001, p<0.001, respectively). The areas under the ROC curve (AUC) were as follows: CAR=0.768 (95% CI, 0.705-0.832), white blood cell count (WBC)=0.735 (95% CI, 0.667-0.802), monocytes=0.622 (95% CI, 0.544-0.699), red cell distribution width-standard deviation (RDW-SD)=0.600 (95% CI, 0.522-0.678), SII=0.674 (95% CI, 0.599-0.748), and neutrophil-to-lymphocyte ratio (NLR)=0.687 (95% CI, 0.613-0.761). CONCLUSION: CAR and SII could be useful biomarkers to differentiate between ACI and BPPV in vertigo patients, but further validation is needed in larger studies.
  • Öğe
    Effects of Intrauterine Isoproterenol Administration on Ovarian Follicular Development in Cows
    (John Wiley and Sons Inc, 2025) Tohumcu, Vefa; Cengiz, Mehmet; Hayirli A.; Altınkaynak, K.; Arslanbaş, Emre; Çıplak, Alper Yasin; Aydın, S.; Alat, Ömercan
    Isoproterenol (ISO) is a nonselective beta-adrenergic receptor agonist known for its vasodilatory effects. This experiment aims to investigate whether intrauterine ISO administration could alter vascular indices and follicular development in postpartum Holstein cows. Objectives: The objectives are to evaluate the effects of intrauterine ISO administration on vascular changes and its impact on follicular development compared to placebo groups. Study Design: This randomized controlled study was conducted on 36 Holstein cows selected based on their health status, including only those free from reproductive, metabolic and infectious disorders. Methods: The cows (n = 36) were divided into two groups as control received distilled water alone (CON, n = 18) and experiment received 4 mg ISO in 40 mL distilled water (ISO, n = 18) and four subgroups as CON-I (n = 9), CON-II (n = 9), ISO-I (n = 9) and ISO-II (n = 9) according to days of intrauterine administration (I or II represents to 1 or 2 days after ovulation, respectively). Uterine and ovarian artery blood flows were assessed before and after administration by Doppler ultrasonography. Blood samples were collected both before and after administration (on Day 1 or 2) and on Days 3, 6 and 9 post-ovulation for hormonal analysis. Antral follicle count (AFC) was recorded on the blood sampling days. Data were analysed via mixed model ANOVA. Results: Intrauterine ISO administration significantly increased the pulse rate (PR) in the ovaries (89.4 vs. 65.5 bpm, p < 0.0001) and uterus (90.6 vs. 64.2 bpm, p < 0.0001). Early AFC (1–2.9 mm) decreased, whereas small AFC (3–4.9 mm) increased in the ISO groups. The weighted average antral follicle size (WAAFS) significantly increased in the ISO group but remained unchanged in the controls. Hormonal analysis revealed elevated levels of FSH (626 vs. 468 mIU/mL), AMH (61.3 vs. 46.4 ng/L), E2 (138 vs. 122 ng/L), P4 (15.3 vs. 10.6 ng/mL), IGF-1 (62.6 vs. 25.1 ng/mL) and IGFBP-3 (28.4 vs. 16.5 ng/mL) in the ISO groups (p < 0.0001). Conclusions: The findings indicate that intrauterine administration of ISO on Day 1 post-ovulation could be a promising ‘adjunct technique’ for future research focussed on minimizing dependence on exogenous hormones or improving the sensitivity of follicles to endogenous hormonal signals, thereby potentially enhancing oocyte yield.
  • Öğe
    Optimal graft choices for tibial plateau fractures with joint depression
    (Turkish Joint Diseases Foundation, 2025) Öktem, Umut; Uysal, Özgur Selim; Dastan, Muhammed Cihan; Bulut, Mustafa; Bozkurt, İbrahim; Bingöl, İzzet; Öçgüder, Durmuş Ali
    This study aims to provide insight into the advantages and disadvantages of autograft and synthetic graft use in the surgical treatment of tibial plateau fractures with joint depression by comparing the clinical and radiological outcomes of both graft types. Patients and methods: Between February 2019 and September 2022, a total of 51 patients (23 males, 28 females; mean age: 45.3±13.5 years; range, 20 to 69 years) who underwent surgical treatment for Schatzker type 2 and type 3 tibial plateau fractures in our clinic were retrospectively analyzed. The patients were divided into two groups; 30 patients received autografts and 21 received tricalcium phosphate synthetic grafts. Demographic data, graft type, fracture classification, preoperative joint depression, body mass index (BMI), and smoking status were recorded. Postoperative evaluations included Lysholm and Visual Analog Scale (VAS) scores at two years.
  • Öğe
    Effects of coadministration of foot and mouth disease vaccine and inactivated parapoxvirus ovis on humoral immunity in cattle
    (Polska Akademia Nauk, 2025) Canbar, R.; Uslu, M.
    Foot and mouth disease (FMD) is an acute viral disease in animals. Inactive parapoxvirus ovis (IPPVO) strengthens humoral immunity. This study aimed to determine the effect of IPPVO application together with FMD vaccine on cattle immunity. It included 30 Holstein cattle randomly divided into two groups: one was administered only the FMD vaccine, and the other was administered the FMD vaccine and IPPVO simultaneously. Control blood was collected from all animals at 0 hours. Serum TNF-α, IL-1β, and IL-6 levels were measured in blood samples collected at 4, 8, 12, 16, and 24 hours post-vaccination, while serum IgG and IgM levels were measured in blood samples collected at 4, 8, 12, 16, and 20 days post-vaccination using ELISA kits. While no changes in serum TNF-α, IL-1β, and IL-6 levels were detected in the FMD group, IL-1β levels significantly increased (peaking at four hours) in the FMD + IPPVO group. In the FMD group, while IgG levels increased significantly (peaking at 16 days), IgM levels did not change. In the FMD + IPPVO group, IgG level on day 8 days was higher than the 16 days value. Also, the IgM level increased significantly on day 16. In conclusion, the application of FMD with IPPVO increases the primary immune response (IgM), but it does not effect the long-term immune response (IgM).
  • Öğe
    Effects of workload and distance traveled on psychological resilience and values among emergency healthcare workers
    (TUBITAK, 2025) Yazıcı, Ramiz; Bala, Efe Demir; Basa Kalafat, Ayşe Fethiye; Sarı, Eyüp; Mutlu, Hüseyin; Güner, Hakan; Kaya, Hilmi; Tapkan, Rabia Birsen; Kalafat, Utku Murat; Doğan, Serkan
    Emergency medical services (EMS) personnel face significant challenges in their daily work, which can lead to burnout and affect their mental well-being. This study aimed to investigate how workload and distance traveled, as specific aspects of EMS work, influence the psychological resilience and values of EMS personnel. The Connor–Davidson Resilience Scale (CD-RISC) and Spiritual and Humanistic Value Scale (SHVS) were utilized to assess psychological resilience and values, respectively. Materials and methods: A cross-sectional study was conducted among EMS personnel in Ankara, Türkiye, utilizing a questionnaire survey distributed between 23 and 30 May 2024. The study was approved by the Medical Research Scientific and Ethical Evaluation Board of Ankara Bilkent City Hospital. A total of 293 EMS personnel participated after providing informed consent and approval. The participants were categorized into 3 groups based on their case/distance ratio. We used the CD-RISC and SHVS to compare psychological resilience and values between the groups. Results: Significant differences were observed according to various sociodemographic and work-related variables among the participating EMS personnel. Younger personnel tended to handle more cases, while older personnel traveled longer distances on average (p < 0.001). Education level and experience also influenced workload allocation, with less experienced individuals and those with lower education levels handling more cases (p < 0.001). No significant differences were found in CD-RISC and SHVS scores between the considered groups; however, we identified significant differences based on sex (p = 0.005) for the CD-RISC and based on age (p < 0.05) and experience (p < 0.05) for the SHVS. Conclusion: This study highlights the complex relationship among workload, sociodemographic factors, and psychological resilience/ values in EMS personnel. Older, more experienced personnel tended to exhibit higher resilience and values scores, suggesting greater adaptation and satisfaction. Understanding these dynamics can aid in developing targeted interventions to prevent burnout and promote the well-being of EMS personnel.
  • Öğe
    Investigation of the Effects of Silymarin on Ovarian Ischemia Reperfusion via Nrf-2/HO-1/NQO1, Ki-67 and Wnt Signaling Pathways
    (John Wiley and Sons Inc, 2025) Öztürk, Ayşe Betül; Akaras, Nurhan; Şimşek, Hasan; Kandemir, Fatih Mehmet
    Ovarian ischemia is a pathological condition that usually occurs due to ovarian torsion, resulting in the interruption of blood supply to the ovaries and oxygen deficiency. Silymarin (SLM) is a flavonoid complex of plant origin with pharmacological properties such as antioxidant, anti-inflammatory, and antiapoptotic effects. In this study, we investigated the effects of SLM through different pathways in rats subjected to experimental ovarian ischemia/reperfusion (I/R). Female Wistar rats were divided into five groups: Control, SLM (50 mg/kg), I/R, I/R + SLM25 (25 mg/kg), and I/R + SLM50 (50 mg/kg). SLM was given orally for 7 days, followed by ischemia (2 h) and reperfusion (2 h) on day 8. Biochemical (MDA, GSH, SOD, CAT, GPx) and histological (H&E, Ki-67 IHC) analyses were performed. Also, molecular (qRT-PCR) analyses were performed to evaluate oxidative stress, inflammation, apoptosis, and Wnt signaling. I/R increased MDA and NO levels in ovarian tissue while decreasing SOD, CAT, GPx, and GSH. Antioxidant defense genes (Nrf-2, HO-1, NQO1) were suppressed, and inflammation markers (NF-ĸB, IL-1β, TNF-α) along with apoptotic markers (Bax, Caspase-3) were elevated, while Bcl-2 decreased. The Wnt signaling pathway was inhibited, particularly at Wnt-3A, LRP5, Dvl-2, and Cyclin-1, reducing Ki-67 protein levels and IHC positivity. Silymarin has shown a therapeutic effect on ovarian ischemia reperfusion injury with its antioxidant, antiapoptotic and anti-inflammatory effects and cell cycle regulatory activity.
  • Öğe
    Protective Effects of Baicalein and Bergenin Against Gentamicin-Induced Hepatic and Renal Injuries in Rats: An Immunohistochemical and Biochemical Study
    (John Wiley and Sons Inc, 2025) Ekinci Akdemir, Fazile Nur; Yıldırım, Serkan; Kandemir, Fatih Mehmet; Küçükler, Sefa; Eraslan, Ersen; Güler, Mustafa Can
    Drug-induced organ toxicity is a significant health concern, with gentamicin known for its effective antibacterial properties but also severe side effects, particularly cytotoxicity in liver and kidney tissues. This current study observed the preventive role of baicalein and bergenin against hepatic and renal injuries caused by gentamicin in rats. Methods: Thirty-two male Sprague Dawley rats were divided into four groups, namely, control, gentamicin (gentamicin 80 mg/kg/day), baicalein (gentamicin 80 mg/kg/day + baicalein 100 mg/kg/day) and bergenin (gentamicin 80 mg/kg/day + bergenin 100 mg/kg/day). Hepatotoxicity and nephrotoxicity were induced by giving gentamicin (80 mg/kg/day). We evaluated the biochemical markers, including alkaline phosphatase (ALP), urea, alanine transaminase (ALT), creatinine and aspartate transaminase (AST) levels, antioxidant enzymes, oxidative stress parameters and histopathological and immunohistochemical changes. Results: Gentamicin increased oxidative stress parameters and decreased antioxidant activity. The treatment with baicalein and bergenin significantly restored these markers. Conclusions: Baicalein and bergenin significantly mitigated gentamicin-induced hepatic and renal toxicity by restoring biochemical markers, reducing oxidative stress and enhancing antioxidant enzyme activity. Histopathological and immunohistochemical analyses confirmed the protective effects of both compounds against organ damage. No statistically significant differences were observed between the two drugs for these parameters. These results suggest their potential as therapeutic agents to prevent gentamicin-induced organ toxicity.
  • Öğe
    Medication Adherence and Functioning in Individuals With Bipolar Disorder Type I
    (Slack Incorporated, 2025) Yılmaz, Emel Bahadır; Türkoğlu Dikmen, Sema Nur; Yüksel, Arzu
    To determine the correlation between medication adherence and functioning in individuals with bipolar disorder (BD) and the predictors of functionality. METHOD: This cross-sectional and correlational study was conducted with 145 individuals with BD type I. Data were collected using a Patient Information Form, the Medication Adherence Rating Scale, and Functioning Assessment Short Test. RESULTS: Findings showed that most participants did not take medication as pre-scribed. Medication adherence was negatively correlated with functionality. Predictors of functionality were years of treatment, number of hospitalizations, working status, medication adherence, family history of mental illness, and history of suicide. CONCLUSION: Medication nonadherence is a fundamental problem for individuals with BD. Nursing interventions to increase functionality and medication adherence among this at-risk group should be planned and implemented.
  • Öğe
    Demographic and Injury Characteristics of Patients Injured in a Hailstorm
    (Cambridge University Press, 2025) Kokulu, Kamil; Sert, Ekrem Taha; Özdemir, Serdar; Mutlu, Hüseyin; Altunok, İbrahim
    The aim of this study was to describe the demographic characteristics, injury characteristics, and outcomes of individuals sustaining injuries during a hailstorm in Istanbul, Turkey. Methods: In this study, the medical records of 76 patients who presented to the emergency department (ED) of a tertiary hospital after incurring injuries due to hailstorms were retrospectively reviewed. Analyses were performed to identify hailstorm-associated injury profiles, injury mechanisms, patient demographics, and ED resource use. Results: Of the 76 patients, 42 (55.3%) were male and 34 (44.7%) were female, with the ages of the patients ranging from five to 79 years. Of the patients, 93.4% presented to the ED within the first eight hours after a hailstorm. The most common injury mechanisms were the direct impact of hailstones on the body surface (36.8%) and slips and falls during escape (35.6%). The most frequently injured anatomical areas were skin (60.5%), head (44.7%), and extremities (16.7%). Significant injuries occurred in only 11.8% of the patients, of whom three were treated surgically and one died. The most common injuries were soft tissue and minor head injuries. Conclusions: Severe hailstorms often strike suddenly and can be difficult to predict. In response, EDs must handle a large number of injured patients in the aftermath of a hailstorm. It is important to remember that hailstorms, like other natural disasters, can cause serious injuries.
  • Öğe
    Comparison of the Acute Effects of Carbohydrate Mouth Rinse and Coach Encouragement on Kinematic Profiles During Small-Sided Games in Young Male Soccer Players
    (Multidisciplinary Digital Publishing Institute (MDPI), 2025) Birinci, Yakup Zühtü; Pancar, Serkan; Soylu, Yusuf
    Carbohydrate mouth rinsing (CHOmr), a nutritional intervention for delaying fatigue and meeting the energy demands of soccer, and the motivational strategy of coach encouragement (CE) are widely recognized as effective approaches for enhancing athletic performance in soccer. Objectives: This study aimed to compare the effects of CHOmr + CE, CHOmr, and CE on heart rate (HR) and kinematic profiles during four-a-side small-sided soccer games (SSGs). Methods: Twenty-four young soccer players (age: 17.2 ± 0.8 years) played six bouts of four-a-side SSGs with CHOmr + CE, CHOmr, or CE at 3-day intervals in a randomized, single-blinded, placebo-controlled, or crossover study design. The HR and kinematic responses were continuously recorded during all games. Results: There were no statistically significant differences between the groups in peak heart rate (HRpeak) (p ≥ 0.05, F = 0.326, p = 0.723, η2 = 0.014) and mean heart rate (HRmean) (p ≥ 0.05, F = 0.845, p = 0.436, η2 = 0.035). No significant differences were found for distances in Zone 1 (p ≥ 0.05, F = 1.21, p = 0.306, η2 = 0.050), Zone 4 (p ≥ 0.05, F = 0.310, p = 0.735, η2 = 0.013), Zone 5 (p ≥ 0.05, F = 1.02, p = 0.368, η2 = 0.042), or Zone 6 (p ≥ 0.05, F = 0.161, p = 0.211, η2 = 0.055), nor acceleration (p ≥ 0.05, F = 0.208, p = 0.137, η2 = 0.083) and deceleration (p ≥ 0.05, F = 0.790, p = 0.460, η2 = 0.033). Similarly, although no significant differences were observed in the distance in Zone 3 (p ≥ 0.05, F = 3.12, p = 0.054, η2 = 0.119) or repeated sprint distance (p ≥ 0.05, F = 2.96, p = 0.062, η2 = 0.114), the CHOmr +CE group exhibited higher average values for these variables. However, a statistically significant difference was observed in the distance covered in Zone 2 (p ≤ 0.05, F = 3.89, p = 0.028, η2 = 0.145), with the CHOmr +CE group performing better, as confirmed by the post-hoc analyses. Conclusions: Although our findings indicate that CE alone may influence kinematic profiles during SSGs, similar to CHOmr or its combination with CE, further research should explore the underlying mechanisms and potential contextual factors influencing these outcomes. Therefore, we suggest that coaches prefer CE because it is easy to implement.
  • Öğe
    Evaluation of the effect of red cabbage waste on performance, egg quality, and yolk oxidative stability of laying Japanese quails (Coturnix coturnix Japonica)
    (Springer Science and Business Media B.V., 2025) Gümüş, Erinç; Sevim, Behlül; Sırakaya, Selim; İriş, Canan; Kahraman, Oğuzhan; Sarmiento-García, Ainhoa
    This study investigates the effects of red cabbage waste (RCW) as a dietary supplement on the performance, egg quality, and oxidative stability of yolk in laying Japanese quails. Given its rich phenolic content, RCW has been investigated as a natural feed additive to reduce food waste and enhance poultry diets. In a six-week trial, 120 quails were divided into 4 groups with 5 replicates and fed diets with 0.0%, 0.5%, 1.0%, and 2.0% RCW. Performance parameters, internal and external egg quality, and antioxidant status were measured. RCW supplementation had no significant impact on overall quail performance. Quails fed with 0.5% RCW showed notable improvements in internal egg quality, especially in the albumen index, Haugh unit, and eggshell thickness. Additionally, incorporating 0.5% RCW into the diet improved the yolk’s antioxidant activity, as evidenced by reduced MDA levels. However, other egg quality traits, including the antioxidant capacity of the yolk, had deteriorated with concentrations above 0.5%, indicating that a moderate inclusion of 0.5% RCW is the most favourable option. The findings underscore that RCW could be sustainably used to improve egg quality without compromising performance, while managing food waste, presenting a potential circular economy solution. Nevertheless, further research is encouraged to optimize RCW levels and fully understand its benefits in poultry feed.
  • Öğe
    Academicians' Metaphorical Perceptions of Older Adult Sexuality: An Example of Metaphor Analysis
    (Springer, 2025) Yüksel, Arzu; Kütmeç Yılmaz, Cemile
    Sexuality is one of the most natural aspects of life that continues throughout life and is within the scope of basic human needs. Sexual life can be affected by many factors such as individual characteristics, diseases, society's values, attitudes, and cultural and religious characteristics. The objective of this research is to identify the metaphorical perceptions of older adults' sexuality held by academics, employing a phenomenological methodology. This study was conducted with the participation of 164 academicians. The research data were collected between March–April 2022. The evaluation of the metaphors created about the concept of older adults' sexuality employed content analysis techniques. The metaphors pertaining to the perceptions of academics regarding the sexuality of older adults were classified into four categories and 11 sub-themes: "Perceptions that sexuality as natural," "Diminishing sexuality," "Sexuality as love, affection and friendship," and "Sexuality as hidden and stigmatized." The majority of the metaphors created by the academic researchers were found to contain negative themes related to the sexuality of older adults. It can be suggested to organize seminars to increase the awareness of academicians on sexuality, older adults' sexuality, and sexual health.
  • Öğe
    Unveiling the Pre-Weaning Growth Performance and Some Reproductive Characteristics of Akkaraman and Central Anatolian Merino Sheep
    (Unveiling the Pre-Weaning Growth Performance and Some Reproductive Characteristics of Akkaraman and Central Anatolian Merino Sheep, 2025) Behrem, Sedat
    This study evaluated growth and reproductive traits in two sheep breeds in Türkiye, Akkaraman (AKK) and Central Anatolian Merino (CAM), with a focus on the impact of non-genetic factors. Data were analysed from 21,414 AKK and 20,099 CAM lambs for birth weight (BW) and 27,528 AKK and 24,639 CAM lambs for weaning weight (WW), average daily weight gain (ADWG) and Kleiber ratio (KR) using a linear mixed model. AKK lambs showed a significantly higher mean BW (4.19 ± 0.01 kg) than CAM lambs (4.02 ± 0.01 kg) (p < 0.001), whereas CAM lambs had significantly higher WW, ADWG and KR (p < 0.001 for each trait). Fixed effects of sex, birth type, dam age, birth year, herd size and season significantly influenced all growth traits (p < 0.05). Male lambs demonstrated higher BW, WW, ADWG and KR than females (p < 0.001), and single-born lambs had significantly higher BW and WW than twins (p < 0.001). Dam age also influenced all growth traits, with lambs from younger dams tending to be heavier (p < 0.001). In terms of survival, AKK lambs exhibited a significantly higher survival rate (93.85%) than CAM lambs (89.50%) (p < 0.001). Conception rates were similar for both breeds (92.9% for AKK and 92.3% for CAM), whereas CAM lambs showed higher fecundity and litter size. These findings underscore the breed differences in growth and reproductive traits and highlight the importance of considering non-genetic factors to inform breed-specific management practices aimed at optimizing productivity.
  • Öğe
    Therapeutic potential of rosmarinic acid in tramadol-induced hepatorenal toxicity: Modulation of oxidative stress, inflammation, RAGE/NLRP3, ER stress, apoptosis, and tissue functions parameters
    (Elsevier Ltd, 2025) Karaca, Onur; Akaras, Nurhan; Şimşek, Hasan; İleritürk, Mustafa; Küçükler, Sefa; Gencer, Selman; Kandemir, Fatih Mehmet
    Tramadol (TRM), a widely used opioid analgesic for moderate to severe pain, is associated with liver and kidney toxicity at high doses or prolonged use. This study investigates the protective role of rosmarinic acid (RA), a natural phenolic compound known for its antioxidant, anti-inflammatory, and cell-protective properties, against TRM-induced hepatorenal toxicity. Methods: Thirty-five male Wistar rats were divided into five groups: Control, TRM, RA, TRM + RA25, and TRM + RA50. Rats received TRM (50 mg/kg) and RA (25 or 50 mg/kg), with liver and kidney function tests, oxidative stress, inflammation, ER stress, apoptosis, and tissue damage indicators assessed through qRT-PCR, ELISA, Western blotting, H&E, and immunohistochemical analysis. Results: TRM induced liver and kidney dysfunctions, evident from increased ALT, AST, ALP, urea, creatinine, nephrin, TIM-1 and 8-OHdG levels, along with activated oxidative stress, inflammation, ER stress, and apoptosis pathways. RA significantly reduced these effects, ameliorating histologic and immunohistochemical markers of tissue damage and inflammation. Conclusion: RA demonstrates therapeutic potential by mitigating TRM-induced hepatorenal toxicity and preserving tissue integrity.
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    Association of the SNP in akirin 2 Gene With Growth and Carcass Traits in Zavot Cattle
    (John Wiley and Sons Inc, 2025) Ertan, Osman Tufan; Arzık, Yunus; Daldaban, Fadime; Arslan, Korhan; Akyüz, Bilal
    Understanding the genetic factors that influence meat yield is crucial due to the economic importance of average daily live weight gain (ADWG) in livestock. This study investigates the relationship between the c.*188G>A SNP in the 3′-UTR region of the akirin 2 gene and growth traits in Zavot cattle, focusing on the gene's role in muscle development. Genotyping of the c.*188G>A SNP was conducted using polymerase chain reaction–restriction fragment length polymorphism analysis, revealing frequencies of 0.09 for AA, 0.75 for AG and 0.16 for GG genotypes, respectively. Our findings demonstrate a significant association between this SNP and ADWG, as well as percentage. These results suggest that the c.*188G>A SNP within akirin 2 could serve as a valuable DNA marker for predicting ADWG and percentage traits in Zavot cattle.
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    The Effects of Positioning During Colonoscopy on Efficacy and Post-procedure Comfort
    (AVES, 2025) Ergin, Mustafa; Ergin, Gülencan Yumuşak; Kıvrakoğlu, Fatih; İbiş, Mehmet
    There are studies with different results on improving effectiveness and patient comfort by increasing lumen distention through positioning during colonoscopy. In our study, we aimed to compare colonoscopy outcomes and post-procedural patient comfort in the left-lateral and right-lateral positions. Materials and Methods: A total of 231 patients who underwent screening colonoscopy were included. Patients were randomized to either the left-lateral or the right-lateral position. Patient age, sex, comorbidities, body mass index (BMI) values, times to reach the cecum, ileum intubation rates, total procedure times, and colonoscopy findings were compared. Pain and discomfort after the procedure were evaluated and compared with the visual analog scale (VAS) scores at 30 minutes, 6 hours, and 24 hours. Results: Colonoscopy was performed in the left-lateral position in 129 patients and in the right-lateral position in 102. The distributions of age, sex, comorbidities, and BMI values were similar in both groups. The time to reach the cecum and the total procedure time were similar in both groups. There were no significant differences in the findings detected by colonoscopy. There was no significant difference in the post-procedural VAS scores. Conclusion: This study failed to show a difference in colonoscopy outcomes and postprocedural discomfort between the left- and right lateral positions.
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    Pan-immune inflammation value and systemic inflammatory index as a measure of systemic inflammation in patients with psoriasis: A retrospective study
    (Lippincott Williams and Wilkins, 2025) Başar Kılıç, Şeyma; Erdal, Hüseyin
    Psoriasis is a chronic immune-mediated disease characterized by systemic inflammation. In recent years, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV) were shown to be important indicators of inflammation. The aim of the present study is to investigate NLR, PLR, SII, SIRI, PIV together in patients with psoriasis. This retrospective case-control study encompassed seventy-one individuals diagnosed with psoriasis and seventy healthy controls who underwent evaluation at the Dermatology clinics of Aksaray University Training and Research Hospital from January 2022 to January 2023. Inflammatory process indicators such as NLR, PLR, SII, SIRI, PIV were computed for analysis. A notable discovery from our research was the indication of a direct relationship between SII and Psoriasis Area Severity Index (PASI) scores. A statistically significant difference was found between the 2 groups in terms of neutrophils, lymphocytes, monocytes, and platelets (P < .05). The area under the curve of the SII score for psoriasis was 0.611. The optimal cutoff value of SII to predict psoriasis activation was 442.7, with 55.7% sensitivity and 45.7% specificity (95% confidence interval 0.518-0.704, P = .024). A positive correlation was observed between SII, PIV and PASI (P = .004, r = 0.34; P = .006, r = 0.32 respectively).There was no statistically significant distinction observed in the PLR indices between the groups (P > .05). The present study investigation demonstrates the potential utility of SII, SIRI, and PIV in assessing psoriasis patients. Moreover, the findings suggest that SII and PIV could function as an autonomous prognostic marker for individuals diagnosed with psoriasis.
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    The Effect of the Maxillary Sinus Volume on the Morphology and Angulation of the Infraorbital Canal in Relation to Age and Gender
    (Springer, 2025) Açar, Gülay; Gökşan, Ahmet Safa; Magat, Güldane
    Although the infraorbital canal (IOC) and maxillary sinus (MS) have been well studied, understanding the effect of MS volume (MSV) on IOC morphology is critical in determining the safest surgical route for infraorbital depression and transmaxillary procedures. Objectives: We aimed to describe the IOC types, measure the MSV and IOC angles (IOCA) in all three planes, and analyse the relationship between them using three-dimensional (3D) cone beam computed tomography (CBCT) images. Methods: CBCT images of 280 patients were analysed to identify the IOC types and accessory IOC (IOCa), and to measure morphometric parameters. The relationship between them was examined using statistical analysis in relation to age, gender, and laterality. Results: The most common IOC type was Type I (59.6%), followed by Type II (21.8%), Type III (13.6%), and Type IV (5%). According to MSV, three types of MS were described, with 38.2, 34.6, and 27.2% having normal, hypoplastic, and hyperplastic MS, respectively. Also, hyperplastic MS was associated with the highest likelihood of Type III IOC. Furthermore, logistic regression model revealed that the MSV and IOCA3 had a positive significant effect on the IOC protrusion, whereas being female, increasing age and IOCA1 had a negative significant effect on MS pneumatization. The probability of having hyperplastic MS, Types II and III IOC, IOCa also decreased with increasing age. Conclusions: Using 3D technology, the results of this study provide a detailed classification of IOC and MS types, increasing the number of treatment options and reducing the risk of complications during surgery. Level of Evidence IV: This journal requires that authors assign a level of evidence to each article.
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    Behind the wall: Macrolithic artifacts as testing tools for activities and social structure on a Middle Chalcolithic site in Central Anatolia
    (Public Library of Science, 2025) Řídký, Jaroslav; Doležalová, Kristina; Pilař, Daniel; Çaylı, Pınar; Demirtaş, Işıl; Gülçur, Sevil
    The main focus of this work is an assemblage of nearly two thousand macrolithic artifacts, weighing more than half a metric ton, retrieved from an excavated area measuring 3,600 m2 of the Middle Chalcolithic site of Güvercinkayası, which dates from the end of the 6th and first half of the 5th millennium cal BCE. The site is ideal for testing different analytical approaches due to the extent of the excavated area, the good preservation of structures and finds, the site layout and the fact that the site is divided into two parts by a fortification wall. Macrolithic artifacts were divided into ten classes according to the method of manufacture, raw materials, shapes and dimensions, and their functional use. Several examples were chosen for use-wear analysis of the active surfaces. The Middle Chalcolithic period in Central Anatolia represents the end of previous Neolithic traditions in architecture and ways of life. Therefore, the main objective of our work is to present the assemblage from this period, and further to test the information potential of these artifacts for studying the activities and social structure of settlements. The shape spectrum of the assemblage largely corresponds to the Neolithic period. It differs mainly in the proportion of some shapes and functional types present. In addition, certain artifacts appear to indicate the existence of some form of counting system or board game. Based on the results of the study of macrolithic artifacts and their statistical and spatial analysis, it is clear that the composition of artifacts and access to raw materials was similar in different parts of the settlement. The inhabitants of the Middle Chalcolithic site created a settlement with a regular layout, which at a certain time was divided into two parts. However, the results of our analyses do not demonstrate any significant patterns that would testify to vertical social stratification of the society living within this settlement.
  • Öğe
    Extra virgin olive oil mitigates lung injury in necrotizing enterocolitis: Effects on TGFβ1, Caspase-3, and MDA in a neonatal rat model
    (Public Library of Science, 2025) Tuşat, Mustafa; Eröz, Recep; Bölükbaş, Ferhan; Özkan, Erkan; Demirtaş, Mehmet Semih; Erdal, Hüseyin; Özocak, Osman Okan
    Necrotizing enterocolitis (NE), which is common in premature babies, has been associated with lung damage. Our aim is to explore the effect of enterally administered extra virgin olive oil (EO) with rich polyphenol content on clinical parameters, histopathological score, Transforming growt factor beta-1 (TGFβ1), Caspase 3 and Malondialdehyde (MDA) levels in NE-related lung injury of neonatal rats. Methods Three groups (control, NE, NE+EO) were created, with 8 neonatal rats in each group. NE was induced by hypoxia-hyperoxia-hypothermia and formula feeding. EO was given to the treatment group by orogastric probe for 3 days. Intestinal and lung tissue were excised for analysis. Results TGFβ1 expression levels, TGFβ1 and MDA concentration levels were higher in the NE compared to NE +  EO and control groups (p < 0.001), and their levels decreased after EO treatment compared to the NE group (p < 0.001). It was determined that EO treatment significantly reduced the histopathological damage and the caspase-3 (CASP3) expression level in the lung (p < 0.001). Conclusion Our findings emphasize that TGFß1 has an crucial function in NE-related lung injury and that EO has therapeutic potential in NE-related lung injury.