Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Gestational Oxidative Stress and OGTT: Are Pregnant Women’s Fears Justified?
(Dove Medical Press Ltd, 2024) Genç, Şerife Özlem; Erdal, Hüseyin
Pregnancy induces significant metabolic, immunological, and endocrinological changes to support fetal growth. The 75-gram oral glucose tolerance test (OGTT) is standard for gestational diabetes screening, but concerns exist about its potential to induce oxidative stress, affecting both maternal and fetal health. The aim of the study is examining changes in oxidative stress markers and thiol/disulfide homeostasis in pregnant women to evaluate these concerns. Patients and Methods: Thirty pregnant women undergoing gestational diabetes screening between the 24th and 28th weeks participated. Blood samples were collected at 0, 60, and 120 minutes as part of the OGTT protocol. Oxidative stress markers were analyzed only in samples from 0 and 120 minutes, while the 60-minute sample was used solely for glucose measurement. Results: Results showed a significant increase in TOS (p = 0.008) and OSI (p = 0.035) post-OGTT, indicating an acute oxidative stress response. Thiol and disulfide levels showed non-significant changes, suggesting that antioxidant mechanisms were largely unaffected. Conclusion: Further research is necessary to explore the long-term implications of these findings and develop strategies to mitigate oxidative stress during pregnancy. This study provides insights into the acute oxidative stress response caused by OGTT in pregnant women. Although the OGTT induces oxidative stress, it does not significantly disrupt the body’s antioxidant capacity in the short term. These results highlight the need for more research to understand the effects of heightened oxidative stress on maternal and fetal health.
The impact of plant proteases and sous vide technology on quality characteristics of meat
(Springer, 2024) Erdem, Nuran; Gökmen, Süleyman
This study aims to assess the impact of protease-rich fruit (kiwi), a rhizome (ginger), and sous vide technology (SVT) on the technological, textural, microstructural, microbiological, and sensory properties of different types of meat, including beef, goose, and rabbit. It was observed that all types of meat treated with kiwi and ginger showed a significant decrease (p < 0.05) in pH and a significant increase (p < 0.05) in water holding capacity and L* parameters compared to those treated with distilled water. The addition of ginger, which contains the enzyme zingibain, was found to enhance the a* parameter across all types of meat. The Texture Profile Analysis (hardness, springiness, gumminess, chewiness) and Extended Craft Knife parameters (firmness and work of shear) in the meat samples significantly decreased (p < 0.05) following the combined treatment of marination and SVT. The study identified zingibain, an enzyme found in ginger, as the most effective for tenderizing beef (p < 0.05). In contrast, actinidin, the enzyme present in kiwi, was found to be the most effective for tenderizing goose and rabbit meats. The microstructural analysis showed significantly larger spaces between muscle fibers in the treated meats compared to the control samples. The combination of plant protease and SVT significantly reduced (p < 0.05) the microorganism count in the meats and received higher texture scores from the panelists (p < 0.05). Furthermore, the purees did not cause any sensory defects.
Knowledge levels and attitudes of Turkish nursing students regarding medical device-related pressure injuries and factors influencing them: A cross-sectional study
(Tissue Viability Society, 2024) Erzincanlı, Saadet; Gürlek Kısacık, Öznur; Sönmez, Münevver
The aim of this study was to determine nursing students' levels of knowledge and attitudes regarding medical device-related pressure injuries (MDRPIs), as well as the factors influencing these. Materials and methods: This descriptive and cross-sectional study was conducted with 581 nursing students between January and May 2024. Data were collected using the Student Information Form, the Medical Device Related Pressure Injury Knowledge Assessment Test (MDRPI-KAT), and the Medical Device Related Pressure Injury Attitude Questionnaire (MDRPI-AQ). Results: The nursing students had a mean score of 8.76 ± 2.68 on the MDRPI-KAT, indicating an overall correct answer percentage of 54.7 %. The mean total score on the MDRPI-AQ was 44.08 ± 8.12. Furthermore, 75.0 % of the nursing students (n = 436) achieved a positive attitude score (>40 points). According to the results of the structural equation model, the scores on the MDRPI-KAT among nursing students had a statistically significant effect on their scores on the MDRPI-AQ (? = 0.585, p = 0.002). Conclusion: This study found that the nursing students exhibited insufficient knowledge about MDRPIs.Despite this, the nursing students demonstrated a positive attitude toward MDRPIs.
Why blood flow restriction cuff features are an important methodological consideration- a short commentary on “cerebral cortex activation and functional connectivity during low-load resistance training with blood flow restriction: an fNIRS study”
(Frontiers Media SA, 2024) Rolnick, Nicholas; Clarkson, Matthew; Korakakis, Vasileios; De Queiros, Victor; Patterson, Stephen D.; Buckner, Samuel; Werner, Tim; Nascimento, Dahan Da Cunha; Stray-Gundersen, Sten; Kamış, Okan; Thoelen, Mathias
We read with great interest the recent study titled “Cerebral cortex activation and functional connectivity during low-load resistance training with blood flow restriction: An fNIRS study” published in PLOS ONE earlier this year (Jia et al., 2024). The study adds to our limited understanding of the cerebral demands of blood flow restriction (BFR) exercise and the potential role of applied pressure. The authors examined cerebral oxygenation levels following squat exercise performed at 30% of one repetition maximum, with bilateral BFR applied at 150, 250, and 350 mmHg using the B-Strong cuffs (B-Strong, USA). The authors noted enhanced cerebral oxygenation levels in many cortical regions which dropped sharply when 350 mmHg was applied.
ChatGPT-4o?s performance on pediatric Vesicoureteral reflux
(Elsevier Ltd, 2024) Akyol Önder, Esra Nagehan; Ensari, Esra; Ertan, Pelin
Vesicoureteral reflux (VUR) is a common congenital or acquired urinary disorder in children. Chat Generative Pre-trained Transformer (ChatGPT) is an artificial intelligence-driven platform offering medical information. This research aims to assess the reliability and readability of ChatGPT-4o?s answers regarding pediatric VUR for general, non-medical audience. Materials and methods: Twenty of the most frequently asked English-language questions about VUR in children were used to evaluate ChatGPT-4o?s responses. Two independent reviewers rated the reliability and quality using the Global Quality Scale (GQS) and a modified version of the DISCERN tool. The readability of ChatGPT responses was assessed through the Flesch Reading Ease (FRE) Score, Flesch-Kincaid Grade Level (FKGL), Gunning Fog Index (GFI), Coleman-Liau Index (CLI), and Simple Measure of Gobbledygook (SMOG). Results: Median mDISCERN and GQS scores were 4 (4–5) and 5 (3–5), respectively. Most of the responses of ChatGPT have moderate (55 %) and good (45 %) reliability according to the mDISCERN score and high quality (95 %) according to GQS. The mean ± standard deviation scores for FRE, FKGL, SMOG, GFI, and CLI of the text were 26 ± 12, 15 ± 2.5, 16.3 ± 2, 18.8 ± 2.9, and 15.3 ± 2.2, respectively, indicating a high level of reading difficulty. Discussion: While ChatGPT-4o offers accurate and high-quality information about pediatric VUR, its readability poses challenges, as the content is difficult to understand for a general audience. Conclusion: ChatGPT provides high-quality, accessible information about VUR. However, improving readability should be a priority to make this information more user-friendly for a broader audience.
