Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Comparison of the effects of Autologous Cytokine-rich Serum (ACRS) and Platelet-Rich Plasma (PRP) on skin wound healing
(Sciendo, 2025) Erol, Hanifi; Karakaş, Erol; Ermiş, Mustafa; Akçakavak, Gökhan; Aslan, Nevzat Emre; Karataş, Özhan
Wound healing is one of the most complex biological events, involving physiological processes such as tissue restoration and intricate cellular and molecular activities. The aim of this study was to investigate the effects of Autologous Cytokine Rich Serum (ACRS) and Platelet-rich plasma (PRP) on wound healing and to compare their impact on tissue repair using histopathological and immunohistochemical methods. A total of 42 healthy Wistar-Albino rats were used as material. The histopathological and immunohistochemical evaluations showed that ACRS is more effective than PRP on wound healing. The superior efficacy of ACRS is attributed to its stimulation of anti-inflammatory cytokines and provision of essential nutrients such as amino acids, vitamins, and lipids. Further detailed studies are recommended to explore these findings.
Lead-Free Na2ZrTeO6 Double Perovskite: A Promising Candidate for High-Temperature and Optoelectronic Applications
(John Wiley and Sons Inc, 2025) Deligöz, Engin; Rached, D.; Özışık, H.; Caid, M.; Rached, Y.
The double perovskite class of materials is highly significant due to its optoelectronic properties and structural stability, making it ideal for applications in electronics, photovoltaics, and catalysis. We present a first principles study of the elastic, anisotropic mechanical, electronic, and optical properties of the newly synthesized double perovskite Na2ZrTeO6 compound. The calculated elastic constants confirm the mechanical stability of the compound. Na2ZrTeO6 exhibits high mechanical durability, a wide band gap, and significant anisotropic mechanical properties. The observed anisotropy suggests that Na2ZrTeO6 may exhibit direction-dependent mechanical and electronic behavior, making it a versatile material for advanced technological applications. The high Debye and melting temperature indicate that Na2ZrTeO6 may be very suitable for high-temperature processes, refractory materials, and high-temperature equipment. This compound is a semiconductor with a wide band gap and the electrons are mobile carriers because they have smaller effective masses. The optical properties, including the real and imaginary parts of the complex dielectric function, energy loss, real and imaginary parts of the refractive index, and absorption coefficient, are analyzed for photon energies up to 20 eV to evaluate the optical response.
Impact of seasonal variations and water quality parameters on the formation of trihalomethanes and haloacetic acids in drinking water treatment processes
(Academic Press, 2025) Alver, Alper; Baştürk, Emine; Kılıç, Ahmet
n this study, the combined effects of seasonal variations and water treatment processes on the formation of disinfection by-products (DBPs), focusing on trihalomethanes (THMs) and haloacetic acids (HAAs) within a full-scale conventional drinking water treatment plant, were investigated. The seasonal analysis revealed that autumn exhibited the highest levels of disinfection by-product formation potential (DBPFP), with trihalomethane formation potential (THMFP) and halo acetic acid formation potential (HAAFP) reaching 255 μg/L and 241 μg/L, respectively, likely due to increased organic matter from leaf fall and runoff. In contrast, winter exhibited the lowest concentrations, with THMFP at 150 μg/L and HAAFP at 56 μg/L. It is attributed to lower temperatures that limit organic matter reactivity. Correlations between 24 water quality parameters and DBPFP types were also examined, identifying critical parameters with the highest correlations. These parameters, including UV254 absorbance and total organic carbon, were used to develop regression models sensitive to seasonal changes and treatment stages. Among the treatment units, the coagulation and aeration stages achieved notable reductions in THM precursors, whereas HAA precursors were less effectively removed, persisting into secondary treatment stages. Chloroform was the predominant THM species, with a peak concentration of 100 μg/L in autumn, decreasing to 76 μg/L in summer, possibly due to increased volatilization in warmer months. For HAAs, dichloroacetic acid displayed the highest seasonal variability, peaking in autumn at 28 μg/L. These findings highlight the need for seasonally adaptive treatment strategies, particularly during high-risk autumn periods when DBPFP levels are elevated. This study provides actionable insights into optimizing treatment protocols to improve DBP control, emphasizing seasonal adjustments’ critical role in ensuring compliance with water quality standards.
Seasonal dynamics and pre-treatment influences on NOM fractions and THM formation potential in a drinking water reservoir: A case study in Aksaray, Turkey
(Elsevier Ltd, 2025) Alver, Alper; Baştürk, Emine; Kılıç, Ahmet
In this study, the seasonal variations of natural organic matter (NOM) and the effects of pre-chlorination and pre-ozonation on disinfection by-product (DBP) formation in Mamasın Dam were investigated. NOM was classified into hydrophilic acids (HIA), hydrophobic neutrals (HON), and other fractions to assess their contributions to trihalomethanes (THMs). Seasonal differences were significant, with total organic carbon (TOC) peaking at 6.564 mg/L in summer due to increased biological activity and dropping to 3.173 mg/L in winter. Pretreatment influenced NOM distribution, with pre-ozonation effectively reducing reactive HON and HIN fractions, leading to a decrease in THM formation potential (THMFP) from 292.5 μg/L in raw summer water to 247.9 μg/L. Regression models (R2 > 0.999) confirmed that HIA and HIN were the dominant THM precursors across all THM species. Model performance was further validated using 10-fold cross-validation, yielding high predictive accuracy across all THM species and confirming the absence of overfitting. Pre-ozonation was more effective than pre-chlorination in lowering THMFP, particularly chloroform, highlighting its superior potential for DBP control. These findings emphasize the critical role of seasonal changes and treatment strategies in NOM reactivity and DBP mitigation. This study provides a framework for fraction-specific and adaptive treatment approaches to improve drinking water safety.
Effect of autologous cytokine-rich serum and platelet-rich plasma administration on oxidative status, minerals and proinflammatory cytokines in brain and serum in cyclophosphamide-induced ovarian failure
(Springer Science and Business Media B.V., 2025) Ermiş, Mustafa; Karakaş, Erol; Erol, Hanifi; Akçakavak, Gökhan; Acı, Recai; Ümit, Furkan; Karataş, Özhan; Çiftçi, Gülay
Cyclophosphamide (CP) is one of the most commonly used chemotherapy agents and carries a high risk of ovarian damage. This study aimed to evaluate the effects of autologous cytokine-rich serum (ACRS) and platelet-rich plasma (PRP) on brain oxidative status, mineral levels, and proinflammatory cytokines in rats with CP-induced ovarian failure. A total of 42 female Wistar rats (12-weeks-old) were used in the study. Six of these rats were allocated as donors, and the remaining 36 rats were randomly distributed into six groups (n = 6 per group). Group 1 received no treatment. On the 1st and 7th days, 75 mg/kg of CP was administered intraperitoneally to Groups 4, 5, and 6. On day 1, PRP was administered intraovarianly to Groups 2 and 5, while ACRS was administered intraovarianly to Groups 3 and 6. Additionally, PRP and ACRS were administered intraperitoneally to the respective groups on 7th and 14th days.The study was terminated at the end of the 31st day. Brain tissue and blood samples were collected for biochemical analyses and ovarian tissue samples were collected for histomorphological examinations. Morphological analysis using Hematoxylin–Eosin (HE) staining and immunohistochemical evaluation for AMH, α-SMA, and IL-1β were conducted on the ovaries. Proinflammatory cytokines and insulin levels were measured using ELISA test kits. TAS/TOS levels were assessed using Relassay Diagnostic kits. Biochemical parameters and mineral levels were measured using autoanalyzer. Histopathological evaluation revealed that follicular degeneration, congestion, hemorrhage, edema, and inflammatory cell infiltration, as well as the number of atretic follicles and IL-1β immunoreactivity, were observed at the highest levels in the CP group (Group 4). In contrast, the numbers of primordial, primary, secondary, and tertiary follicles, along with AMH and α-SMA immunoreactivity levels, were found to be the lowest in this group. However, positive therapeutic effects were observed in the CP-treated groups (Groups 5 and 6). In the serum, increased levels of AST, ALT, creatinine, glucose, LDL, TOS, Ca, Fe, Mg, IL-1β, IL-1α, TNF-α, and NF-kB were detected in the CP groups (G4, G5, G6) compared to the control groups (G1, G2, and G3). In brain tissue, a decrease of total protein and total cholesterol levels were observed in the CP groups (G4, G5, G6) compared to the control groups, while increases in Na, Cl, Fe, IL-1β, IL-1α, TNF-α, and NF-kB levels were detected. In conclusion, PRP and ACRS therapies from the patient's own blood have a potential as supportive or chemopreventive strategies with reduced side effects and treatment costs.
