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Successful implantation of a dual-chamber permanent pacemaker in a patient with persistent left superior vena cava and absence of right superior vena cava: tips and tricks
(Czech Society of Cardiology, 2025) Demir, Vahid; Yıldırım, Oğuz; Keskin, Pınar; Gül, Murat; Aktaş, Halil; İnci, Sinan
An absent right superior vena cava associated with persistent left superior vena cava (PLSVC) is a rare and generally asymptomatic congenital malformation. It is usually discovered incidentally during pacemaker (PM) implantation. In this report, we describe our experience with implanting a dual-chamber pacemaker in a patient with such complex anatomy and the clinical value of peripheral phlebography for clearly describing venous anatomy in the surgical room. In particular, we highlight the methods used to ensure correct lead positioning.
Investigation of protective effects of rutin\cyclodextrin inclusion complex against testicular damage caused by diisononyl phthalate in rats
(Mashhad University Medical Sciences, 2025) Bozalı, Ramazan; Akarsu, Serkan Ali; Gür, Cihan; Küçükler, Sefa; Akaras, Nurhan; Leritürk, Mustafa; Sunar, Serhat; Kandemir, Fatih Mehmet
The aim of this study was to investigate the protective effects of Rutin\cyclodextrin (RUT\CD) complex in rats exposed to diisononyl phthalate (DINP). Materials and Methods: In the study, 35 male Sprague Dawley rats were used. The rats were randomly divided into five groups: Control, DINP, RUT\CD, DINP+RUT\CD100, and DINP+RUT\CD200. The control group received Tween 80 by oral gavage, while the DINP groups received DINP at a dose of 200 mg/kg/bw. RUT+CD groups received the RUT\CD complex by oral gavage. After 14 days of administration, rats were sacrificed, and testicular tissues were used for histopathological and biochemical analyses, and epididymal tissues were used for semen analysis. Results: DINP administration caused an increase in MDA level and a decrease in SOD, CAT, GPx1 enzyme activities, and GSH level in rats. RUT\CD administration decreased oxidative stress and increased antioxidant activity. In addition, DINP administration caused a decrease in Nrf-2 and HO-1 levels. DINP caused a significant increase in eIF2 alpha, ATF4, NF-kappa B, TNF-alpha, IL-1 beta, IL-6, Inos, and Cox2 levels in the testicular tissue of rats. RUT\CD administration decreased these levels in a dose-dependent manner. Apoptosis markers p53, Apaf-1, Bax, Bcl-2, and Caspase-3 mRNA transcript levels and Bax and Bcl-2 protein levels were significantly increased in the DINP-administered group. In the DINP+ RUT/CD group, these levels decreased in a dose-dependent manner. Moreover, DINP administration caused an increase in sperm DNA damage. Conclusion: DINP administration induced testicular toxicity by increasing oxidative stress, apoptosis, and inflammation, and changes in testicular histology. Moreover, RUT\CD administration attenuated DINP-induced toxic effects.
The impact of employee responsiveness on perceived crowding outcomes: Evidence from Türkiye as an emerging market
(Istanbul University School of Business, 2025) Bakırtaş, Hülya
This study explores the role of employees as a possible influencer in tempering consumers'crowding outcomes. The research was conducted in the context of T & uuml;rkiye, an emerging market characterized by a collectivist culture. This research fills a gap in the existing literature on the cultural influences on the retail environment and consumer behavior interactions. The proposed conceptual model is empirically analyzed using data from a field survey of over 500 consumers intercepted at a shopping mall in Bursa, T & uuml;rkiye. Findings show that employee responsiveness plays a mediating role between consumers' crowding experience and their patronage intentions and satisfaction. In contrast to previous results, findings in the Turkish cultural context indicate a positive relationship between retail crowding and shopping outcomes, including customer satisfaction and behavioral intentions (repurchase and recommendation). Moreover, employee responsiveness had a non-significant moderating effect. This study contributes to the previous literature on the impact of culture on consumers by examining the link between retail crowds and shopping outcomes in a developing country. This relationship is well demonstrated in the marketing literature, but primarily in the context of developed economies.
Impacts of phenol formaldehyde (PF) and melamine urea formaldehyde (MUF) adhesives strengthened with nano chemilas on screw withdrawal strength of laminated wood elements
(Gazi Üniversitesi, 2025) Kara, Mehmet Erdal; Özcifçi, Ayhan
The aim of this study was to determine the effect of SiO2 and TiO2 modified phenol-formaldehyde (PF) and melamine-urea formaldehyde (MUF) glues and nanoproducts on radial, tangential and perpendicular screw withdrawal strength of wood laminates. For this purpose, LVL and GLULAM materials were obtained by gluing the test specimens arranged from Uluda & gbreve; fir (Abies bornm & uuml;lleriana mattf.) and aspen (Populus tremula) wood species with PF and MUF glues adjusted with 2% and 4% SiO2 and TiO2 nanoproducts in a high frequency press. The screw withdrawal strength of the resulting laminates was determined according to TS 10506 and compared with control samples. In conclusion the use of nano products had a positive effect on screw withdrawal behavior. By comparing the test results with the in-group control samples, the nano product effect level of each experiment was determined. Accordingly, the highest screw withdrawal strength (8.31 Nmm(2)) was found in poplar-LVL specimens modified with 4% SiO2 nanoproduct and bonded with MUF adhesive. Consequently, it was resoluted that laminated materials obtained by using adhesives modified with nanoproducts have higher screw withdrawal strength than the control samples. In conclusion, high-quality GLULAM and LVL wood composites can be used in interior and exterior area by bonding poplar wood products in the tangential direction with PF and MUF glues strengthened with TiO2 and SiO2 chemicals.
Mapping the research landscape of stormwater quality improvement devices: trends, influencers, and thematic evolution (1992-2024)
(MDPI, 2025) Yua, Sesugh; Yıldırım, Gökhan; Morshed, Mohammad Ataul; Anindita, Monisha; Alim, Mohammad A.; Rahman, Ataur
This study presents a comprehensive bibliometric analysis of the research landscape on Stormwater Quality Improvement Devices (SQIDs) covering 1992-2024. Using data from the Web of Science (WoS) and utilizing Bibliometrix R-package 5.1.0 and VOSviewer 1.6.20, this study identifies key trends, influential contributors, and the thematic evolution within SQIDs research. The findings reveal distinct growth phases driven by policy shifts, scientific advancements, and an increasing global emphasis on sustainability. Keyword analysis highlights a significant thematic transition post-2015, with terms like performance, runoff, and management (Keyword Plus), and stormwater management, green infrastructure, and stormwater (Author Keywords) indicating a strong shift toward sustainable, nature-based solutions. Bioretention system has emerged as the most researched SQIDs, reflecting widespread academic and practical interest. The most prolific countries in SQIDs research are the USA, China, and Australia, while prominent thought leaders include Fletcher (Monash University), Wang (Guangzhou University), Shuster (US EPA), and Deletic (UNSW). Leading publication outlets include the Journal of Environmental Management, Science of the Total Environment, Journal of Hydrology, and Water. Overall, this study underscores the field's maturation toward policy-relevant and interdisciplinary innovations, long-term performances and smart SQIDs using artificial intelligence positioning SQIDs as vital tools in addressing urban stormwater management challenges globally.
Evaluation of acute scrotal pathologies in pediatric emergency settings: a retrospective analysis of etiologies, clinical presentations, and management timelines
(Springer, 2025) Özdemir Kaçer, Emine; Tuşat, Mustafa
Acute scrotal pathologies are characterized by sudden onset of pain, swelling, and redness in the scrotum. This condition is commonly observed in male patients presenting to emergency departments. Prompt diagnosis and treatment are crucial for effective management of this condition. The objective of this study is to evaluate the etiology, clinical presentation, sociodemographic characteristics, and timelines for presentation, diagnosis, and treatment in boys diagnosed with acute scrotum.Study designThis retrospective study reviewed the files of male patients under the age of 18 who were admitted to our pediatric emergency department between July 2019 and July 2024 with a diagnosis of acute scrotum. The data collected encompassed a wide range of information, including sociodemographic characteristics, the etiology of acute scrotum, the presenting complaints, the physical examination findings, the time interval from the onset of symptoms to presentation, imaging studies, and surgical consultations.ResultsA total of 151 cases were identified, with ages ranging from 0 to 17 years. The etiologies included epididymitis (n = 43), torsion of the appendix of the testis (n = 33), testicular torsion (n = 28), scrotal cellulitis (n = 23), incarcerated/strangulated inguinal hernia (n = 15), trauma (n = 8), and Henoch-Sch & ouml;nlein purpura (n = 1). The most prevalent presenting complaints were swelling (n = 39, 30.7%) and pain (n = 36, 28.3%). While the time to presentation and imaging were similar across cases, surgical consultation was significantly faster for patients with testicular torsion.ConclusionIn pediatric emergency settings, acute scrotum necessitates meticulous evaluation. Early diagnosis and timely intervention are imperative to avert complications, including testicular loss, and to ensure the patient's well-being.
The limits and possibilities of democracy: a study of Rousseau's political philosophy
(Beytü'l-Hikme, 2025) Evren, Mehmet
This study aims to examine Jean Jacques Rousseau's understanding of democracy in the context of social contract theory and the concept of general will. The study also aims to question the influence of Rousseau's understanding of democracy on contemporary political philosophy and its place in current democracy debates. In particular, the distrust of representative systems at the global level, the revival of direct democracy tools (digital participation, referendums, etc.) and the interest in collective decision-making mechanisms explain why Rousseau's thought is still relevant. In this respect, Rousseau's vision of radical democracy retains the potential to offer an alternative political imaginary in a context of neoliberal authoritarianism, erosion of citizenship rights and deepening participation deficit.
Urinary total superoxide dismutase activity is low in rheumatoid patients, and its low levels are associated with higher DAS28 scores
(Elsevier, 2025) Kor, Mehmet; Yalçın, Merve; Okyar, Göktuğ; Kor, Tahire Betül; Doğan, İsmail; Atalar, Ebru; Konak, Hatice Ecem; Dağlı, Pınar Akyüz; Tam, Dudu Çelik; Işık, Sema; Polat, Bünyamin; Neşelioğlu, Salim; Erel, Özçal; Erten, Şükran
Rheumatoid factor and anti-citrullinated peptide antibodies are generally used to diagnose rheumatoid arthritis (RA). However, these antibodies are negative in 15-20 % of RA cases. This study aimed to investigate new biomarkers that can be used in diagnosing RA and evaluating disease activity. Methods: This study included 99 RA patients and 94 healthy volunteers. Modified Disease Activity Score28 (DAS28) erythrocyte sedimentation rate (ESR) was used for disease activity score. Thiol/disulfide molecules were measured using an automatic spectrophotometric method, and ischemia-modified albumin was measured using an albumin-cobalt binding test. A spectrophotometer calculated urinary and serum total superoxide dismutase (SOD) activities at 420 nm wavelength. Results: In the RA group, serum IMA level was higher (unstandardized beta [B]: 5.552, Odds Ratio [OR]: 250.1, CI 95 %: 1.29-48219.1, p: .040), and urinary total SOD activities were significantly lower (B: 2.640 OR: .071, CI 95 %: .027-.192, p < 0.0001) than in the control group. A cut-off value of 5.06 for urinary total SOD was found to have a sensitivity of 97.9 % and a specificity of 97 % in distinguishing RA patients from healthy controls (AUC [95 %Cl] = .986 [.967-1.000], p < 0.001). Urinary total SOD activity was significantly lower in the RA subgroup with high disease activity compared to the groups with moderate disease activity (B: .954, OR: 2.596, CI 95 %: 1.104-6.103, p: .029) and low disease activity (B: 1.251, OR: 3.494, CI 95 %: 1.143-10.678, p: .028). Conclusion: This study showed that urinary total SOD activity has high sensitivity and specificity in distinguishing RA patients from healthy controls and that RA patients with higher DAS28 ESR activity scores have lower urinary total SOD activity.
A comparative analysis of the performance of large language models in the basic life support exam: comprehensive evaluation of ChatGPT-4o, Gemini 2.0, Claude 3.5, and DeepSeek R1
(Bayrakol Medical Publisher, 2025) Bulut, Bensu; Öz, Medine Akkan; Genç, Murat; Gür, Ayşenur; Yortanlı, Mehmet; Yortanlı, Betül Çiğdem; Yazıcı, Ramiz; Mutlu, Hüseyin; Kotanoğlu, Mustafa Sırrı; Çınar, Eray
Considering the growing role artificial intelligence technologies play in medical education, this study aims to provide a comparative evaluation of the performances of large language models ChatGPT-4o, Gemini 2.0, Claude 3.5 , DeepSeek R1 in the Basic Life Support (BLS) Exam. Materials , Methods: In this observational study, we presented four large language models with 25 multiple-choice questions based on the American Heart Association (AHA) guidelines. Questions were divided into two categories as knowledge-based (n = 14, 56%) and case-based (n = 11, 44%). Response consistency was ensured by presenting each question on three separate days to all models. Models' accuracy rates were assessed using overall accuracy, strict accuracy, and ideal accuracy criteria. Results: In the overall accuracy assessment, ChatGPT-4o and DeepSeek R1 models showed 100% success, and Gemini 2.0 and Claude 3.5 models achieved 96% success rate. All models performed perfectly on the case-based questions. On the knowledge-based questions, ChatGPT-4o and DeepSeek R1 scored full points, while Gemini 2.0 and Claude 3.5 achieved 90.9% success. Statistical analysis showed no significant difference between results (p = 0.368). Discussion: Large language models show high accuracy rates in BLS training. These technologies can be used in supportive roles in medical education, but human supervision is critical in clinical decision-making.
Evaluation of the systemic immune-inflammation index in relation to histological stages of celiac disease
(BMC, 2025) Kıvrakoğlu, Fatih; Ergin, Mustafa
Celiac disease (CD) is an immune-mediated enteropathy characterized by histopathological changes, such as villous atrophy and chronic inflammation, often assessed using the Marsh classification. The systemic immune-inflammation index (SII), a novel inflammatory biomarker, has been increasingly investigated in chronic inflammatory diseases, including CD.ObjectiveThis study aims to evaluate the relationship between SII and histopathological progression in CD, as classified by the Marsh scores, and to assess other hematological and inflammatory parameters.MethodsA retrospective analysis was conducted on 115 biopsy-confirmed CD patients from 2 hospitals between February 2022 and November 2023. Demographic, clinical, and laboratory data were analyzed, and SII values were calculated. Statistical comparisons were performed across Marsh stages.ResultsSII levels did not significantly differ among Marsh groups (p = 0.408). However, the Marsh Grade 3a group exhibited higher median SII values compared to others. Hemoglobin (Hb) levels showed significant differences across Marsh stages (p = 0.012), with a notable decrease in Marsh Grade 3c. Other parameters, such as ESR and CRP, showed no significant variation across groups.ConclusionWhile SII shows potential as an inflammatory marker, its limited association with histological stages suggests a need for larger, prospective studies to validate its utility in clinical practice.
Role of stromal area and tumor:stroma ratio in predicting response to neoadjuvant chemoradiotherapy in rectal cancer patients
(Springer Wien, 2025) Şahingöz, Eda; Aydın, Arzu Hazal; Turhan, Nesrin; Tez, Mesut
Neoadjuvant chemoradiotherapy (nCRT) improves outcomes in locally advanced rectal cancer (LARC). However, the response varies, thus necessitating predictive markers. Methods We analyzed 44 LARC patients treated with nCRT followed by surgical resection. Pretreatment biopsies were evaluated for the tumor:stroma ratio (TSR) and stromal area using digital image analysis by two pathologists. Pathological response was graded with the College of American Pathologists Tumor Regression Grade (CAP-TRG). Results Good/partial responders (TRG 0-2) comprised 68.2% of the cohort. Median stromal area was lower in good/partial responders (2.5 mio. px(2) vs. 3.3 mio. px(2); P = 0.006). Median TSR was higher in good/partial responders (0.85 vs. 0.38) but not significantly (P = 0.137). Receiver operating curve (ROC) analysis identified a stromal area cut-off of 2.9 mio. px(2) (area under the curve [AUC] 0.745, sensitivity 80.77%, specificity 64.29%; P = 0.009) for a poor response. Multivariate regression confirmed stromal area (odds ratio [OR] 2.14, 95% confidence interval [CI] 1.12-4.09; P = 0.021) and perineural invasion (OR 3.45, 95% CI 1.33-8.94; P = 0.010) as independent predictors. Conclusion Higher stromal area predicts a poorer nCRT response in LARC, while TSR trends toward significance. Stromal area may guide personalized treatment, pending larger cohort validation and practical implementation in clinical settings.
Comparison of patient adherence and treatment response in patients with chronic viral hepatitis: results of a 48-week observational study
(Galenos Publishing House, 2025) Yıldırım, Seval Sönmez; Kürklü Bozkır, Filiz; Köksal, İftihar
Viral hepatitis is one of the significant health problems in the world. The main purpose of treatment is virological eradication. There are many factors that determine treatment response. The most important factor that can be affected is treatment adherence. In our study, we aimed to compare compliance with treatment response, which is one of the factors that can be affected in chronic viral hepatitis patients. We highlight that this element should be considered in treatment failures, especially in chronic diseases that require long-term treatment. Materials and Methods: Chronic hepatitis patients over 18 years of age and under 65 years of age, who were neither co-infected with Human immunodeficiency virusnor pregnant, were prospectively analyzed after receiving ethics committee approval. Treatment adherence was defined as taking the prescribed medication in the required number of doses and for the required duration. Drug count and questionnaires were used in the compliance assessment. Patients' compliance and patients' 12, 24, 36, and 48th-week virological responses were compared. Results: Seventy-six patients were included in the study. Sixty point five percent of patients had chronic hepatitis B, and 39.5% had chronic hepatitis C. According to the drug count data, it was determined that 83.9% of the patients did not take their treatment during at least one visit. At the end of the treatment (48th-week follow-up), 89.4% of all chronic hepatitis patients were compliant and 92.6% of the compliant patients responded to the treatment. Five out of eight non-compliant patients, accounting for 62.5%, were able to respond to the treatment. Response rates of compliant and non-compliant patients to treatment were found to be statistically significant. Conclusion: Non-adherence to treatment in chronic viral hepatitis is infrequent. Given the increased risk of virological failure in poorly adherent patients, clinicians should keep in mind adherence issues in every patient treated for viral hepatitis.
Protective effect of N-acetylcysteine in doxorubicininduced primary ovarian failure in female rats
(Galenos Publishing House, 2025) Aslan, İlke Özer; Öz, Mehmet; Erdal, Hüseyin; Karaboğa, İhsan; Doğan, Mehmet
N-acetylcysteine (NAC), an aminothiol compound, eliminates free radicals and enhances glutathione (GSH) synthesis, thereby strengthening intracellular antioxidant defenses. Although its protective effects against ovarian injury have been reported, its efficacy in doxorubicin (DOX)-induced ovarian failure has not been demonstrated. This study aimed to investigate whether NAC exerts a protective role against DOX-induced ovarian toxicity in female rats. Materials and methods: Twenty-one adult female rats were randomly assigned to three groups: Control, DOX (10 mg/kg, i.p., single dose), and DOX+NAC (150 mg/kg, i.p., for 5 days; DOX administered on day 3, one hour after NAC). Serum and tissue oxidative stress parameters, histopathological changes, proliferating cell nuclear antigen (PCNA) immunoreactivity, and TUNEL assay were evaluated. Results: DOX significantly reduced serum anti-M & uuml;llerian hormone (AMH) (6.75 -> 5.31 ng/mL; p<0.001) and GSH (422.64 -> 280.98 mg/L; p<0.001), while increasing tumor necrosis factor alpha (TNF-alpha) (175.87 -> 260.77 ng/L; p<0.001) and total oxidant status (TOS) (7.18 -> 11.84 U/mL; p=0.002). NAC treatment reversed these alterations, namely: AMH (6.51 ng/mL; p=0.004), GSH (363.86 mg/L; p=0.018), TNF-alpha (184.55 ng/L; p<0.001), TOS (7.88 U/mL; p=0.003). In ovarian tissue, DOX reduced GSH (123.63 -> 80.64 mg/L; p=0.001) and total antioxidant status (14.88 -> 10.57 U/mL; p<0.001), while elevating TOS (7.14 -> 12.64 U/mL; p<0.001) and caspase-3 (2.06 -> 3.14 ng/mL; p<0.001). NAC significantly improved all these parameters (p <= 0.005). Histologically, DOX caused edema, hemorrhage, infiltration, and a reduction in the percentage of healthy follicles, whereas NAC markedly ameliorated these alterations. Furthermore, NAC enhanced PCNA expression and reduced TUNEL-positive granulosa cells, supporting its anti-apoptotic effect. Conclusion: NAC preserved ovarian reserve and follicular integrity by suppressing oxidative stress, inflammation, and apoptosis induced by DOX. These findings highlight NAC as a promising protective agent against chemotherapy-induced ovarian toxicity.
Factors predicting incidentally found appendiceal tumors following appendectomy: propensity score matching analysis
(Sage Public Inc, 2025) Er, Sadettin; Göktaş, Abidin; Özden, Sabri; Akın, Merve; Akın, Mercan; Martlı, Hüseyin Fahri; Aydın, Arzu Hazal; Birben, Birkan; Acehan, Fatih
Purpose The factors that predict coincidental appendiceal neoplasms in patients who underwent appendectomy due to appendicitis were investigated.Methods 5829 patients diagnosed with appendicitis and underwent appendectomy in the department of surgery were examined. Among these patients, patients with appendiceal neoplasia and benign pathology were selected by propensity score matching analysis in a ratio of 1:4. As a result of analysis, 74 and 274 patients were grouped as appendiceal neoplasia and benign pathology, respectively.Results The mean age of the 348 appendiceal neoplasia and benign pathology groups included in the study was 45.6 and 46.4, respectively. Appendiceal diameter, contrast enhancement in the appendix wall, and neutrophil count were independent parameters for appendiceal neoplasia pathology. The AUC value of the combination of appendix diameter, lack of enhancement in the appendix wall, and neutrophil count in distinguishing appendiceal neoplasia pathology was 0.787.Conclusion Appendix diameter, lack of wall enhancement, and neutrophil count are the three predictive indicators useful in helping clinicians suspect appendiceal neoplasms.
Dynamic alteration of halp score as a predictor in patients with receiving immunotherapy for advanced non-small cell lung cancer
(MDPI, 2025) Koçanoğlu, Abdülkadir; Karakaya, Serdar; Zeynelgil, Esra; Düzköprü, Yakup; Doğan, Özlem
This study aimed to investigate the prognostic value of the hemoglobin-albumin-lymphocyte-platelet (HALP) score-a marker reflecting both inflammatory and nutritional status-in patients with metastatic non-small cell lung cancer (NSCLC) undergoing immunotherapy. We also sought to determine whether dynamic changes in the HALP score during treatment could predict therapeutic success and help distinguish between pseudoprogression and hyperprogression. Materials and Methods: A retrospective analysis was conducted on 160 patients diagnosed with metastatic NSCLC and treated with immunotherapy at the Ankara Atat & uuml;rk Sanatorium Training and Research Hospital. Chemotherapy regimens, metastatic sites, baseline and third-month hemograms and biochemistry parameters, and survival data were recorded. Survival outcomes were analyzed using the Kaplan-Meier method with the log-rank test and the Cox proportional hazards regression model using IBM SPSS Statistics. Results: The median overall survival (OS) for the entire cohort was 15 months (95% CI: 11.88-18.12). HALP1 score (p = 0.048), HALP2 score (p = 0.026), and hyperprogression (p < 0.001) were statistically significant predictors of OS. Regarding progression-free survival (PFS), the HALP2 score (p = 0.031), line of immunotherapy (p = 0.046), and hyperprogression (p < 0.001) were found to be significant. When comparing patients with increasing versus decreasing HALP scores, those with increasing HALP scores demonstrated significantly better outcomes for both OS (p = 0.034) and PFS (p = 0.007). Conclusions: In patients with metastatic NSCLC undergoing immunotherapy, the HALP score and its dynamic alterations during treatment appear to be non-invasive, easily calculable biomarkers that may predict both OS and PFS.
Pseudo-Meigs syndrome owing to a retained fibroid following total laparoscopic hysterectomy for multiple leiomyomas: A case report and review of the literature
(Wiley, 2025) Atılgan, Adeviye Elçi; Dilmaç, Ayşegül Evren; Akcaoğlu, Tuğba
Total laparoscopic hysterectomy (TLH) is the most common gynecologic procedure for fibroids. However, massive serous ascites has not yet been reported. For this reason, the management of ascites is challenging because it is an unexpected situation. We present the case of a 42-year-old woman complaining of menorrhagia who was diagnosed with multiple leiomyomas on ultrasound examination. No abnormal findings were observed in the endometrium or ovaries. TLH and bilateral salpingectomy were performed. Specimens were extracted via vaginal morcellation using a scalpel. No intraoperative complications were observed. The final pathologic examination of the uterus, which contained 25 fibroids and tubes, was benign. However, serous ascites began to enter the drain on the first day. The volume of the ascites was approximately 9000 mL over 3 days. There were no abnormalities in vital signs, liver test results, or serum albumin, electrolyte, or hemoglobin levels. Radiologic images excluded bowel and urinary tract injuries. However, an intra-abdominal mass measuring 26 x 33 x 44 mm was detected on magnetic resonance imaging. Diagnostic laparoscopy revealed a myoma between the bowel loops, which was removed by placing it in an endobag. Thereafter, the ascites spontaneously resolved. Ascitic fluid is generally observed in gynecologic cancers. The basic treatment principles include close monitoring of vital signs, appropriate replacement of fluid deficits, drainage, and mobilization. Furthermore, treatment based on the etiopathology is crucial. In cases of multiple myomas, when extracting the uterus vaginally, a pedunculated myoma may break off or be missed in the abdomen. Leiomyomas have oncotic properties and can induce fluid flow from the intravascular to the peritoneal space. Rapid resolution of ascites after myoma removal indicates pseudo-Meigs syndrome.
Fritillaria sanandajensis (Liliaceae), a new species from western Iran
(Magnolia Press, 2025) Advay, Mahfouz; Tekşen, Mehtap; Soleimani, Fahmi
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Geometry of Kenmotsu Manifolds via Q-Curvature Tensor and Schouten-Van Kampen Connection
(MDPI, 2025) Yıldırım, Mustafa; Beyendi, Selahattin; Ayar, Gülhan; Aktan, Nesip
This research paper aims to study the Q-curvature tensor on Kenmotsu manifolds endowed with the Schouten-van Kampen connection. Using the Q-curvature tensor, whose trace is the well-known Z-tensor, we characterized Kenmotsu manifolds by introducing the notion of zeta-Q flat and phi-Q flat manifolds and novel tensor conditions, such as Q(xi,X)Q=0, Q(xi,X)R=0, Q(xi,X)C=0, Q(xi,X)S=0, Q(xi,X)H=0, and Q(xi,X)P=0, with the Schouten-van Kampen connection. To validate some of our results, we constructed a non-trivial example of Kenmotsu manifolds endowed with the Schouten-van Kampen connection.
Effect of castration at different ages on growth and carcass characteristics of Kilis goats: Physicochemical changes and fatty acid profile of meat
(Consejo Superior de Investigaciones Científicas (CSIC), 2025) Gül, Sabri; Dursun, Ahmet; Türkmen, Dilek; Keskin, Mahmut; Güler, Zehra; Gündüz, Zuhal
In this study, the effects of castration at different months of age on carcass and meat characteristics in goats reared under semi-extensive prolonged fattening conditions were investigated. Area of study: The experiment was conducted in the Yayladag & imath; district of Hatay province, Turkiye. Material and methods: The experiment was conducted with 48 male goats from the Kilis goat breed randomly allocated to 4 groups of 12 individuals each. Intact goats (uncastrated goats) functioned as the control group. Each of the other 3 groups was castrated using burdizzo forceps at the 4(th), 6(th), and 8(th) months after birth. During the experiment, all goats were exposed to the same management and feeding conditions. The effects of castration age on growth, carcass and slaughter parameters, as well as the muscle characteristics of the Longissimus thoracis, Semitendinosus, Psoas major, Triceps brachii, and Vastus lateralis were investigated. Main results: At the end of the fattening period, castration at 4-months age increased the weight of muscle tissue (P <0.05) and fat deposition (P <0.001). Additionally, an increase in intramuscular fat and tenderness of the meat, and a decrease in redness and cooking loss were observed with castration at 6-months age (P <0.05). Despite the increase in adiposity with early castration, the oleic acid and the ratio of unsaturated fatty acids to saturated fatty acids (UFA:SFA), hypocholesterolemic/hypercholesterolemic index (h/H) and Delta(9) desaturase index of the meat tended to increase as the castration age decreased. In conclusion, the most appropriate castration age is at 6-months in terms of growth performance and at 4-and/or 6-months in terms of meat quality. Research highlights: Castration of goats at the correct age plays a crucial role in managing herd dynamics, enhancing meat quality, improving efficiency, and meeting market demands in goat farming.
Brucellosis case presenting with bicytopenia due to hemophagocytic syndrome
(Bayrakol Medical Publisher, 2025) Kürklü Bozkır, Filiz; Yıldırım, Seval Sönmez; Çiftçiler, Rafiye
Hemophagocytic syndrome is a rare syndrome of excessive inflammation and tissue destruction due to abnormal immune activation and inflammation. Brucellosis is one of the rare causes of hemophagocytosis. Several reports revealed the relationship between hemophagocytosis and brucellosis. In this case, a case of brucellosis presenting with bicytopenia due to hemophagocytic syndrome is presented by blood and bone marrow culture analyses. The Rose Bengal test, Coombs' test and the standard tube agglutination test were performed and were negative. Brucella melitensis was isolated in the blood and bone marrow cultures on the seventh day of incubation. After the diagnosis was confirmed by bone marrow biopsy and blood culture analyses, antibiotic treatment (oral doxycycline 200 mg/day and rifampicin 600 mg/day for 6 weeks) was immediately initiated. Bone marrow aspiration biopsy has shown platelets, neutrophils, and lymphocytes phagocytosed by macrophages. Peripheral blood counts of the patient returned to normal levels after 2 weeks of antibiotic treatment of brucellosis. Antibiotic treatment was stopped after 6 weeks of therapy once patient's complaints have resolved.

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