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Öğe Comparison and accuracy assessment of unmanned aerial vehicle and terrestrial measurement in base map production(Elsevier B.V., 2025) Yıldız, Veysel; Yaman, AydanIn the present era, unmanned aerial vehicles (UAVs) have become a prevalent tool for data and map production in the domain of remote sensing and photogrammetry, driven by advancements in technology. The production of base maps has become more straightforward, precise, economical, and time-efficient in recent years, largely due to the advent of UAVs and the subsequent development of new techniques. The base maps of the area were produced using two methods: Terrestrial measurement and UAV data. The squared mean errors were calculated and found to be my = ±1.49 cm, mx= ±1.58 cm and mz = ±2.52 cm for ground control points, my = ±1.54 cm, mx= ±1.65 cm and mz = ±2.55 cm for check points and my = ±2.41 cm, mx= ±2.66 cm and mz= ±3.47 cm for detail points. The results were found to fall within the specified limit values. It was therefore concluded that UAVs provide the anticipated accuracy for the production of base maps, which are required to be continually updated and form the basis for a range of projects and can be readily employed in this regard. This study demonstrates that base maps produced with UAV data meet the requisite scientific and academic standards, including accuracy and precision. Additionally, it illuminates the advantages of UAV data in base map production, particularly in terms of time, accuracy, and cost.Öğe Exploring the relationship between learning climate in schools and agile leadership using multi-group path analysis: does “Willingness to work” have a mediating role(Springer, 2025) Sözer Boz, Esra; Tabak, HasanThe learning climate in schools is significantly influenced by relationships among teachers, students, and school administration. Despite its importance, relatively few studies have explored the relationship between learning climate and principal characteristics from teachers’ perspectives. This study aims to examine the mediating role of teachers’ willingness to work in the relationship between the learning climate in schools and agile leadership. The participants consist of 630 teachers from various educational levels, ranging from preschool to high school. Data were collected using the Agile Leadership Scale, the Learning Climate Scale, and an item assessing teachers’ willingness to work. Mediation analysis was employed to examine the impact of teachers’ willingness to work on the relationship between agile leadership and the learning climate in schools. The findings revealed that willingness to work serves as a mediator in the relationship between the learning climate in schools and agile leadership. Multi-group path analysis indicated that this mediation effect was significant among male teachers, whereas they were not observed among female teachers. The overall results demonstrate that the learning climate in schools is affected by the agile leadership of the principals, and the willingness to work of teachers partially mediated this relationship. These findings underscore the importance of agile leadership behaviors in fostering a conducive learning climate and suggest that supporting teachers’ professional and personal development can further enhance this environment.Öğe The Effects of Positioning During Colonoscopy on Efficacy and Post-procedure Comfort(AVES, 2025) Ergin, Mustafa; Ergin, Gülencan Yumuşak; Kıvrakoğlu, Fatih; İbiş, MehmetThere are studies with different results on improving effectiveness and patient comfort by increasing lumen distention through positioning during colonoscopy. In our study, we aimed to compare colonoscopy outcomes and post-procedural patient comfort in the left-lateral and right-lateral positions. Materials and Methods: A total of 231 patients who underwent screening colonoscopy were included. Patients were randomized to either the left-lateral or the right-lateral position. Patient age, sex, comorbidities, body mass index (BMI) values, times to reach the cecum, ileum intubation rates, total procedure times, and colonoscopy findings were compared. Pain and discomfort after the procedure were evaluated and compared with the visual analog scale (VAS) scores at 30 minutes, 6 hours, and 24 hours. Results: Colonoscopy was performed in the left-lateral position in 129 patients and in the right-lateral position in 102. The distributions of age, sex, comorbidities, and BMI values were similar in both groups. The time to reach the cecum and the total procedure time were similar in both groups. There were no significant differences in the findings detected by colonoscopy. There was no significant difference in the post-procedural VAS scores. Conclusion: This study failed to show a difference in colonoscopy outcomes and postprocedural discomfort between the left- and right lateral positions.Öğe Evaluation of the necessity of simultaneous cholecystectomy in patients undergoing liver hydatid cyst surgery(Elsevier B.V., 2025) Martlı, Hüseyin Fahri; Aydın, Arzu Hazal; Şahingöz, Eda; Duru, Derviş; Er, Sadettin; Turhan, Nesrin; Tez, MesutLiver hydatid cysts remain a significant public health issue in Turkey, the Middle East, East Asia, and Russia. Surgical treatments are often employed for certain stages of this disease. However, the necessity of simultaneous cholecystectomy during these procedures remains unclear. Treating symptoms related to subsequent cholelithiasis can become more challenging. This study investigates the necessity of simultaneous cholecystectomy by following patients who underwent hydatid cyst surgery with or without concurrent cholecystectomy. Materials and methods: Patients who underwent surgery for hydatid cysts between 2019 and 2024 at the General Surgery Clinic of Ankara Bilkent City Hospital were retrospectively reviewed. A total of 97 patients were included, with 56 (54.32 %) undergoing cholecystectomy along with hydatid cyst surgery (Group 1) and 41 (45.68 %) not undergoing cholecystectomy (Group 2). Preoperative clinical, laboratory, and radiological findings, as well as intraoperative data, morbidity, mortality, and postoperative symptoms, were analyzed. Results: Patients in Group 1 had longer hospital stays, higher blood loss, and significantly higher Clavien-Dindo complication scores. In the postoperative follow-up of Group 2, 8 patients (19.51 %) developed stones or sludge, and 1 patient (2.4 %) developed polyps. Four patients (9.75 %) presented to the emergency department with cholecystitis symptoms. A total of 5 patients (12.19 %), including 4 with symptomatic cholelithiasis (9.7 %) and 1 with gallbladder polyps (2.4 %), underwent elective cholecystectomy. Two (40 %) of these cholecystectomies were performed laparoscopically, while three (60 %) were converted to open cholecystectomy. Conclusion: Simultaneous cholecystectomy during liver hydatid cyst surgery may prevent difficulties associated with treating symptoms related to subsequent cholelithiasis.Öğe Pan-immune inflammation value and systemic inflammatory index as a measure of systemic inflammation in patients with psoriasis: A retrospective study(Lippincott Williams and Wilkins, 2025) Başar Kılıç, Şeyma; Erdal, HüseyinPsoriasis is a chronic immune-mediated disease characterized by systemic inflammation. In recent years, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune-inflammation value (PIV) were shown to be important indicators of inflammation. The aim of the present study is to investigate NLR, PLR, SII, SIRI, PIV together in patients with psoriasis. This retrospective case-control study encompassed seventy-one individuals diagnosed with psoriasis and seventy healthy controls who underwent evaluation at the Dermatology clinics of Aksaray University Training and Research Hospital from January 2022 to January 2023. Inflammatory process indicators such as NLR, PLR, SII, SIRI, PIV were computed for analysis. A notable discovery from our research was the indication of a direct relationship between SII and Psoriasis Area Severity Index (PASI) scores. A statistically significant difference was found between the 2 groups in terms of neutrophils, lymphocytes, monocytes, and platelets (P < .05). The area under the curve of the SII score for psoriasis was 0.611. The optimal cutoff value of SII to predict psoriasis activation was 442.7, with 55.7% sensitivity and 45.7% specificity (95% confidence interval 0.518-0.704, P = .024). A positive correlation was observed between SII, PIV and PASI (P = .004, r = 0.34; P = .006, r = 0.32 respectively).There was no statistically significant distinction observed in the PLR indices between the groups (P > .05). The present study investigation demonstrates the potential utility of SII, SIRI, and PIV in assessing psoriasis patients. Moreover, the findings suggest that SII and PIV could function as an autonomous prognostic marker for individuals diagnosed with psoriasis.Öğe Multi-Objective optimization and thermodynamic analysis of a supercritical CO2 Brayton cycle in a solar-powered multigeneration plant for net-zero emission goals(Elsevier Ltd, 2025) Bakırcıoğlu, Veli; Yılmaz, Fatih; Jond, Hossein B.The development, design, examination, and optimization of carbon-free power generation models are essential to achieve a sustainable future with net-zero emissions. This study introduces a novel multigeneration system, uniquely combining a supercritical CO2 Brayton cycle and a transcritical CO2 Rankine cycle, supported by a solar parabolic trough collector. The system integrates a reverse osmosis desalination unit, enabling simultaneous production of clean water, heating, and power. A multi-objective optimization framework is implemented by the NSGA-II algorithm, coupled with the TOPSIS method, to explore and identify optimal operational conditions. The innovation lies in the comprehensive consideration of solar incident angles and their impact on system performance, a rarely addressed aspect in the literature. Detailed thermodynamic analysis highlights system performance, achieving a net power capacity of 1052 kW, freshwater generation of 90.44 m3/h, and hot water generation of 1614 kW. The optimized results demonstrate significant improvements in overall energy (50.28 %) and exergy efficiency (22.31 %), showcasing the system's potential as a benchmark for sustainable, zero-emission energy solutions.Öğe Hybrid GIS-MCDM Based Modeling Approach for Determination of Land Suitability of Wheat Cultivation in Konya Closed Basin, Türkiye(Ankara University, 2025) Yaman, Aydan; Mutlu, MertIn countries with high population growth and migration potential, such as Türkiye, agricultural lands are gradually decreasing due to the increase in food demand and the misusage policies and urbanization applied to the lands. Land suitability activities carried out within the scope of agricultural sustainability in order to increase agricultural production and soil productivity are important. This study focuses on identifying the agricultural lands suitable for wheat cultivation by evaluating the Konya closed basin in the Central Anatolia Region of Türkiye by using a hierarchy developed with the integration of the AHP method, which is one of the GIS and MCDM techniques. Within this framework, 15 criteria were delineated under 4 main headings as meteorological criteria, topographic criteria, soil criteria, infrastructure and economic criteria and their weight values for their sub-criteria were calculated. The most effective criteria were determined as the average temperature of October (0.1379), followed by the average annual temperature (0.1300) and the land use capability (0.1191). Finally, the land suitability map was created for wheat cultivation. According to the suitability map, 0.39% (15 815 km2) of the study area is found to be very highly suitable for wheat cultivation, 61.24% (2 494 461 km2) is found to be highly suitable in terms of suitability. The districts of Kadinhani, Sarayonu, Altinekin, Cihanbeyli, Kulu, Karapinar and Emirgazi, which are located in the north of the study area, have been determined as very suitable regions for wheat cultivation. This study aims to contribute to the existing literature by identifying precise and suitable areas by combining GIS and AHP in the wheat cultivation site selection process. In the study, a new research perspective is presented by taking into account the uncertainty in the site selection process and the concept of sustainability in four different dimensions: meteorological, topographical, soil, and infrastructure and economic, thus aiming to guide decision-makers for future studies. According the current literature, that no comprehensive study has yet been conducted that covers such a large basin for the wheat plant, which is the raw material of humanity's basic nutritional needs. In addition, the average annual pressure criterion that is not examined in the literature was discussed in the study and its importance for wheat plant development was also examined. Consequently, the outcome of this study delineates that the methods and criteria used in this study may be guiding for site selection for wheat cultivation in future studies covering such wide areas.Öğe Bibliometric analysis of studies on the concept of social welfare in the Web of Science between 1991 and 2023(Emerald Publishing, 2025) Sipahi Döngül, Esra; Öztürk, HaticeSocial welfare, while it expresses the general well-being, happiness and quality of life of individuals and society, can also affect the social, economic and psychological situations of individuals and society. It is aimed at examining in detail the research trends and developments regarding the concept of social welfare within the scope of international research in the literature. Design/methodology/approach: In this study, the bibliometric analysis of the studies published between 1991 and 2023 on the concept of social welfare in the Web of Science (WOS) was analyzed with the VOSviewer (Version 1.6.9) package program. Findings: This study indicates that 3,276 works on the topic of “Social Welfare” were produced. Examining the year-based distribution, 2021 has the most publications (381 works), making it the year with the highest number. Journal articles have the most publishing types, with 2,974 works. There are 3,276 published works, all in English. Upon analysis of the most frequently used keywords that were connected to one another in the study and were used at least twice, it was found that “child welfare” was the most used term with 214 repeats, followed by “social work” with 183 repetitions and “welfare state” with 154 repetitions. In terms of publications on social welfare, social work (1,233 works) and management (679 works) are the research disciplines with the most. In terms of the works, they produce in the field of social welfare, it has been shown that the USA (502 works) and the UK (650 works) are pioneers. Research limitations/implications: Considering the limited interdisciplinary studies on social welfare and the gap in this field, it has become necessary for researchers, practitioners and policymakers to focus on this issue. This study is limited to the bibliometric analysis of English language studies published in the WOS database between 1991 and 2023 on the concept of social welfare on March 20, 2024, it is recommended to investigate similar studies in different databases in certain periods in order to explore research trends from the perspective of different disciplines. Practical implications: This study with bibliometric analysis provides forward-looking insights into social welfare on the basis of research, practice and policy. The dominance of social welfare research by major publishing houses and leading academic institutions demonstrates the influence of this field in the literature. However, it should be noted that the promotion of different types of publications, such as books and book chapters, can contribute to the enrichment of the literature in this field. In particular, book studies with in-depth analyses and critical approaches can help expand the body of knowledge in the field of social welfare. Social implications: By encouraging international conference papers, social welfare policies implemented in different countries can be discussed in the context of academics, experts and policymakers. At this point, it can be suggested that research in the field of social welfare should be expanded to cover different geographical regions and cultural contexts. Increasing social welfare work in regions such as Asia and Africa can contribute to a better understanding of societal issues in these regions. Originality/value: Considering the limited number of interdisciplinary studies on social welfare and the gap in this field, it can be stated that this study is original in terms of revealing research trends on social welfare.Öğe Thyme (Thymus vulgaris L.) essential oil supplementation: impact on performance, egg quality, serum, and faecal mineral content in laying partridges(Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (CSIC-INIA), 2025) Başer, Eyüp; Sevim, Behlül; Akbulut, N. Kürşad; Çufadar, Yusuf; Halıcı, İbrahim; Kal, Yavuz; Tekik, Havva; Gültekin, Meltem; Sarmiento-García, AinhoaThis study evaluated the impact of thyme (Thymus vulgaris L.) essential oil (TEO) supplementation on performance, egg quality, and serum and faecal mineral composition in chukar partridges (Alectoris chukar). Area of study: Türkiye. Material and methods: Ninety-layer partridges, aged 32 weeks, were randomly assigned to five groups. Within each group, there were six replicates with three birds/replicate. The experimental design included a control group receiving a basal diet (0 mg/kg TEO) and four treatment groups with diets supplemented with TEO at 50, 100, 150, and 200 mg/kg over 56 days. Main results: The results showed no significant differences in performance parameters among the groups (p>0.05). However, egg production and mass were significantly higher in the 50 mg/kg TEO group than in the control group (p<0.01). Additionally, eggshell thickness and yolk index were improved in the 50 mg/kg group compared to the 100 mg/kg group (p<0.05). Serum and faecal mineral compositions did not differ significantly among the experimental groups (p>0.05). Research highlights: These results suggest that incorporating TEO at 50 mg/kg into the diet of chukar partridges may be optimal, as higher concentrations could potentially interfere with nutrient absorption and negatively affect partridge attributes. Nevertheless, further research is needed to elucidate the mechanisms of action of TEO´s active ingredients in partridge feed.Öğe The Effect of the Maxillary Sinus Volume on the Morphology and Angulation of the Infraorbital Canal in Relation to Age and Gender(Springer, 2025) Açar, Gülay; Gökşan, Ahmet Safa; Magat, GüldaneAlthough the infraorbital canal (IOC) and maxillary sinus (MS) have been well studied, understanding the effect of MS volume (MSV) on IOC morphology is critical in determining the safest surgical route for infraorbital depression and transmaxillary procedures. Objectives: We aimed to describe the IOC types, measure the MSV and IOC angles (IOCA) in all three planes, and analyse the relationship between them using three-dimensional (3D) cone beam computed tomography (CBCT) images. Methods: CBCT images of 280 patients were analysed to identify the IOC types and accessory IOC (IOCa), and to measure morphometric parameters. The relationship between them was examined using statistical analysis in relation to age, gender, and laterality. Results: The most common IOC type was Type I (59.6%), followed by Type II (21.8%), Type III (13.6%), and Type IV (5%). According to MSV, three types of MS were described, with 38.2, 34.6, and 27.2% having normal, hypoplastic, and hyperplastic MS, respectively. Also, hyperplastic MS was associated with the highest likelihood of Type III IOC. Furthermore, logistic regression model revealed that the MSV and IOCA3 had a positive significant effect on the IOC protrusion, whereas being female, increasing age and IOCA1 had a negative significant effect on MS pneumatization. The probability of having hyperplastic MS, Types II and III IOC, IOCa also decreased with increasing age. Conclusions: Using 3D technology, the results of this study provide a detailed classification of IOC and MS types, increasing the number of treatment options and reducing the risk of complications during surgery. Level of Evidence IV: This journal requires that authors assign a level of evidence to each article.Öğe Characterizing the Helminth Community of the Mountain Gazelle (Gazella gazella Pallas, 1766) Through DNA Metabarcoding(Springer Science and Business Media Deutschland GmbH, 2025) Karaer, Mina Cansu; Karataş, Büşra; Madak, Elif; Sönmez, Hande İrem; Keskin, Emre; Sarımehmetoğlu, Hıfsı Oğuz; Kankılıç, Tolga; Tavşanoğlu, ÇağatayUnderstanding parasite diversity in wild and captive animal populations is vital for their individual health and ecosystem dynamics. The helminth community in mountain gazelles (Gazella gazella Pallas, 1766), particularly in the isolated northernmost population in Türkiye, remains poorly understood, posing challenges for conservation. This study aimed to identify and compare the diversity of helminths in captive and free-ranging mountain gazelles in Hatay, Türkiye, while assessing potential zoonotic risks. Methods: We collected a total of 188 fresh fecal samples from both captive and free-ranging populations. The samples were analyzed using DNA metabarcoding to assess helminth species and their species diversity across seasons. Results: Our findings revealed eight helminth taxa in Gazella gazella, including six intestinal and two lung nematodes, with four of these species previously unreported in Türkiye. We also found seasonal differences in helminth composition and abundance. Conclusions: The identification of these helminth taxa highlights the value of advanced molecular techniques in uncovering parasite diversity in ungulates. Seasonal differences in helminth composition and abundance, and the biological characteristics of the detected helminth species align with the climatic parameters of the seasons in which they were identified.Öğe Determinants of Fertility Rates in OECD Countries: A Panel ARDL Bounds Testing Approach(Sage Publications India Pvt. Ltd, 2025) Demirci, Şenol; Konca, Murat; İlgün, GülnurThe fertility rate affects countries in many ways, including education, health care, social security and economic systems. It was important to understand the short-run and the long-run determinants of the total fertility rates (TFRs) in Organisation for Economic Co-operation and Development (OECD) countries. This study aimed to examine the short-run and the long-run effects of gross domestic product (GDP) per capita, labour force participation (LFP) rate for females, and mean age at first birth on the TFR in OECD countries for the period between 1991 and 2017 by employing a panel autoregressive distributed lag (ARDL) method. According to the results, GDP per capita and mean age at first birth statistically significantly affected the TFR both in the long run and the short run (p <.05). The effects of these two variables should be taken into account in population planning.Öğe Predictive insights into arsenic remediation: Advancing electro and chemical coagulation through machine learning models(Elsevier Ltd, 2025) Dönmez Öztel, Merve; Alver, Alper; Akbal, Feryal; Altaş, Levent; Kuleyin, AyşeArsenic contamination in water sources remains a critical environmental and public health challenge, mainly due to the toxicity of its trivalent (As(III)) and pentavalent (As(V)) forms. This study compares advanced predictive modeling to enhance arsenic remediation, comparing electrocoagulation (EC) and chemical coagulation (CC) processes for their efficiency and cost-effectiveness. Higher As(III) removal rates were achieved using iron and aluminum electrodes in EC (up to 99 % in 5 min using Fe electrodes) compared to CC (up to 90 % using Fe(II) coagulant). The study's results highlight the operational advantages of EC, including a 40 % cost reduction due to lower chemical usage and sludge production. Machine learning models, including Support Vector Machines (SVM), Regression Trees, Random Forest, and Gradient Boosting, were developed to predict removal efficiencies under diverse operational conditions. SVM exhibited the highest predictive accuracy for As(III) removal in EC with Fe electrodes (MSE = 0.340, R2 = 0.954). At the same time, Regression Trees outperformed other models for As(V) removal in CC with Fe(III) coagulants (MSE = 0.371, R2 = 0.997). These techniques are highly effective in optimizing arsenic removal processes, allowing for precise regulation of treatment parameters and reducing dependence on trial-and-error methods. The findings highlight electrocoagulation with iron electrodes as a sustainable and cost-effective approach to arsenic remediation, particularly for As(III), while underscoring the transformative role of predictive modeling in water treatment. This study successfully integrates experimental insights with machine learning, driving improvements in the efficiency and adaptability of arsenic removal technologies.Öğe Determination of the Experiences of Patients Transferred from the Intensive Care Unit to the Ward(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Tekinsoy Kartın, Pinar; Bozot Kayasan, Dilek; Özdemir, ÜlküPatients in intensive care units (ICUs) face factors that cause anxiety, fear, pain, depression, and adverse health behaviors. This qualitative study aims to determine patients’ experiences when transferred from the ICU to the ward. Methods: Thirteen individuals who were transferred from the ICU to the ward were included in this study. Interviews were conducted using a face-to-face method in the patient’s room. The interviews were recorded with a voice recorder with the consent of the patients. Codes, categories, and themes were created, and content analysis and descriptive analysis were carried out after the audio recordings were converted into text. Results: Patients reported receiving adequate physical and personal care in the ICU and were satisfied with its continuity. They felt safe due to the close attention of healthcare professionals and continuous treatment. Although they received psychological and social support from nurses, they were negatively affected by constant lights, patient noises, and nursing conversations. Patients experienced anxiety about not knowing the health status and time of day, about their relatives, their homes, and other critically ill patients in intensive care. Some patients reported fear of not being able to leave the intensive care unit, relapse, disability, or death. Patients reported pain due to the cold environment, lighting, probes, drains, and positioning. Patients suggested that healthcare personnel communicate better with them, have a clock they can see, reduce noise, and have caregivers of the same gender. They emphasized the need for moral support. Conclusions: Constant light in the intensive care unit, sounds from other patients, nurses talking among themselves, not being able to see their relatives, not knowing what time of day it is, and wondering caused anxiety in the patients. It was determined that patients experienced pain due to catheter, drain, aspiration procedures, cold environment, and position in bed. Notably, patients reported that they needed moral support and wanted to receive care from caregivers of the same gender.Öğe Effects of Morin on the Wnt, Notch1/Hes1, KI-67/3-Nitrotyrosine and Damage Signaling Pathways in Rats Subjected to Experimental Testicular Ischemia/Reperfusion(Springer International Publishing, 2025) Öztürk, Ayşe Betül; Şimşek, Hasan; Akaras, Nurhan; Kandemir, Fatih MehmetTesticular torsion, which occurs when the testicle rotates around the axis of the spermatic cord, is a serious cause of hospital admission, mostly in newborns and children, but also in adults. Oxidative stress is an important mediator of the development of complications. Morin has anti-inflammatory, anti-autophagic, and anti-apoptotic activities and especially strong antioxidant activity. This study aimed to determine the effects of Morin on testicular torsion injury. Methods: 35 Wistar rats were divided into 5 groups (n = 7): Control, Morin, I/R, I/R + MRN50, and I/R + MRN100. Parameters are effective in oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and autophagy damage and Wnt pathway parameters, KI-67, and 3-NT levels were analyzed by biochemical, molecular, and histological methods. Results: I/R injury significantly increased oxidative stress (MDA, p < 0.001) and reduced antioxidant activity (GSH, SOD, CAT, GPx; p < 0.001). MRN administration reversed these effects, with higher doses showing greater improvement (p < 0.01 for CAT, p < 0.001 for others). Inflammation markers (NF-kB, IL-1β, TNF-α, COX-2, iNOS) were elevated in the I/R group, but MRN reduced their expression (p < 0.001). MRN also mitigated ER stress and reactivated the Wnt signaling pathway, particularly at 100 mg/kg (p < 0.001). Additionally, MRN reduced apoptosis (Caspase-3, Bax, p < 0.001) and autophagy (Beclin-1, LC3A, LC3B, p < 0.001), and improved testicular histology and sperm parameters. MRN treatment restored sperm density, motility, and viability (p < 0.05), with higher doses proving more effective. Conclusion: MRN has effects properties in testicular I/R injury by inhibiting many damage pathways and activating protective mechanisms.Öğe Determination of the effect of Tarantula cubensis alcoholic extract on cadmium embryotoxicity(Urmia University - Faculty of Veterinary Medicine, 2025) Canbar, Rahmi; Akçakavak, Gökhan; Uslu, Muhittin; Arslan, Mustafa Sedat; Kızılay, HarunTarantula cubensis alcoholic extract (TCAE) is a homeopathic product used in the veterinary field. This study aimed to determine the effects of TCAE on cadmium (Cd) toxicity in the embryo. The study used 220 fertile, incubated chicken eggs divided into 11 equal groups on the 7th day of incubation. The groups comprised untreated and physiological saline control groups, a group with TCAE alone, four groups with varying doses of Cd alone and four groups with the same doses of Cd plus TCAE. At the end of the incubation period, the eggs were opened, kidney and liver tissue samples were taken for histopathology and the number of dead and living embryos were recorded. In the prsent study, the median lethal dose of Cd was determined to be 0.029 mg per egg and the median lethal dose of Cd plus TCAE was determined to be 0.020 mg per egg. The histopathological examinations determined that kidney and liver damage were increased when TCAE and Cd were administered together, that was higher than when Cd was given alone. Thus, TCAE, which had no toxic effect on the embryo when used alone, might increase the embryotoxic activity of Cd. However, more detailed studies are needed.Öğe Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways(Mashhad University of Medical Sciences, 2025) Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; İleritürk, Mustafa; Kandemir, Fatih MehmetDiclofenac (Diclo) is a therapeutic agent used in the treatment of pain and inflammatory diseases, but it is also toxic to the human body. Morin is a flavonoid found naturally in plants and has many biological and pharmacological activities, including anti-inflammatory, anti-oxidant, and anticancer activities. This study aimed to investigate the efficacy of Morin in Diclo-induced testicular toxicity. Materials and Methods: Morin (50 mg/kg and 100 mg/kg) was administered orally for five days, while Diclo was administered intraperitoneally at 50 mg/kg on days 4 and 5. Biochemical, molecular, and histological methods were used to investigate oxidative stress, inflammation, apoptosis, and endoplasmic reticulum (ER) stress damage indicators in testicular tissue. Results: Morin treatment attenuated Diclo-induced oxidative stress damage by increasing anti-oxidant levels (SOD, CAT, GPx, GSH, Nrf-2, HO-1, and NQO1) and decreasing MDA levels, an indicator of lipid peroxidation. Morin reduced levels of the inflammatory mediators NF-κB protein. Increases in apoptotic Bax and Caspase-3 by Diclo were reduced by Morin, while decreased antiapoptotic Bcl-2 level was increased. Morin reduced Diclo-induced ER stress injury by decreasing ATF-6, PERK, IRE1, GRP-78, and CHOP levels. Also, Diclo decreased COX-2 levels. Conclusion: Overall, Morin may be an effective treatment of choice for testicular tissue damage associated with Diclo toxicity and may reduce the level of damage.Öğe Effects of erythropoietin on cardiac morphometry in exercised male and female adolescent rats(Urmia University - Faculty of Veterinary Medicine, 2025) Ateş, Mehmet Burak; Akçakavak, Gökhan; Özdemir, Özgür; Özdemir, Mehmet; Bozkurt, İbrahimErythropoietin (EPO) is a glycoprotein hormone predominantly produced in the kidneys, primarily stimulating erythroid cell proliferation in the bone marrow. The present study investigated the impact of EPO combined with swimming exercise on cardiac morphometry in adolescent male and female rats. The 4-week study involved 48 rats (24 males and 24 females), which were divided into four main groups of six males and six females each. The control group was administered intraperitoneal saline four times a week. The swimming exercise group also received intraperitoneal saline, followed by 30 min of swimming exercise, four times a week. The drug control group was given 50.00 IU kg-1 epoetin alfa intraperitoneally, four times a week. Lastly, the Swimming + Drug group received 50.00 IU kg-1 epoetin alfa intraperitoneally, four times a week, followed by 30 min of swimming exercise. The post-study measurements demonstrated that EPO administration did not result in notable alterations in crucial parameters, including the left ventricular mass index, left ventricular mass, and left ventricular posterior wall in the context of left ventricular hypertrophy in both genders. However, in female rats, EPO-only group and the combined EPO and exercise group showed significant thinning of the right ventricular wall and interventricular septum indicating potential cardiac dilatation. The results highlight the necessity of considering gender-specific responses when evaluating EPO's cardiovascular effects, particularly concerning the right ventricle, and suggest further investigation into the long-term consequences of these observed changes.Öğe Use of the CHA2DS2‑VASc Score to Predict Concurrent Critical Coronary Artery Stenosis in Patients with Severe Carotid Artery Disease(Wolters Kluwer Medknow Publications, 2025) Baran, O.; Yılmaz, Y.; İnci, S.; Çetinkaya, Z.; Keleşoğlu, S.There is a significant correlation between the severity of atherosclerosis in one arterial region and the occurrence of atherosclerotic disease in other regions. Identifying and managing vascular disease in patients with multifocal arterial disease is often complex. The CHA2DS2-VASc score encompasses several cardiovascular risk factors and was initially used to assess the risk of thromboembolism, stroke, and death in patients with atrial fibrillation. In recent years, this score has been proposed to predict the prognosis of various cardiovascular diseases. Aim: The study aimed to investigate the prevalence of concomitant coronary artery disease (CAD) and the correlation between the CHA2DS2-VASc score and CAD in patients who were scheduled for carotid stenting due to carotid artery stenosis (CAS) but had no history of CAD. Methods: A total of 452 patients were included in the study, 213 with symptomatic CAS and 239 with asymptomatic CAS. The patients were separated into two groups: those with and without. Results: One hundred forty-eight (32.7%) of 452 patients had critical CAD. Multivariate logistic regression analysis showed that a high CHA2DS2-VASc score (OR: 4.283, 95% CI: 2.903–6.321, P < 0.001) was an independent predictor of the development of CAD. Receiver operating characteristic curve (ROC) analysis showed 64.9% sensitivity and 82% specificity in detecting CAD of the CHA2DS2-VASc score at >4 cutoff [Area under ROC curve = 0.781 (95% CI: 0.724–0.838), P < 0.001]. Conclusion: When our results were analyzed, a CHA2DS2-VASc score of >4 was highly significant in predicting severe CAD.Öğe Active surface modification of thermoplastic polyurethane-oleic acid nanocomposite fibers through alkali hydrolysis(John Wiley and Sons Inc, 2025) Karahaliloğlu, Zeynep; Hazer, BakiAlkali hydrolysis is a simple, low-cost, and prominent surface modification method for developing more desirable scaffolds. In the presented study, two distinct concentrations (1 and 3 M) were predetermined for the hydrolysis treatments, and thermoplastic polyurethane (TPU) nanocomposite fibers with varying concentrations of oleic acid (OLE) were exposed. According to the scanning electron microscopy (SEM) images, when naked TPU or nanocomposite fibers showed any morphological changes, the interfacial bonding points of TPU-OLE nanocomposite fibers enhanced in the higher concentrations of hydrolysis solution (1 and 3 M). The average fiber diameter in pure TPU is 0.59 ± 0.04 μm, while after doping with the highest concentration of OLE, the fiber diameter decreased to 0.48 ± 0.03 μm. Additionally, at the highest NaOH and OLE concentrations, the diameter decreased from 0.85 ± 0.02 μm in 3 M/TPU to 0.61 ± 0.04 μm in 3 M/TPU-OLE3. Additionally, the surface hydrophilicity of TPU-OLE fibers was noticeably improved through alkali hydrolysis, compared to the naked TPU approximately by 70%. Furthermore, the surface characterization of fibers revealed that the surface roughness values showed a significant change with increasing alkali concentration, but were not affected by the OLE concentration. All these findings indicate that TPU, whose surface wettability, roughness, and antibacterial response are modified by mercerization and OLE addition, can be safely and successfully used in tissue engineering applications. Highlights: Polyurethane, oleic acid, and NaOH treatment were combined for tissue engineering applications. TPU/OLE nanofiber membranes were prepared by electrospinning. The surface of composite fibrillar membranes was modified alkali hydrolysis. The fiber diameter decreased after NaOH hydrolysis. Alkali hydrolysis improved the surface wettability and antibacterial response.
