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Öğe Correction to: the effect of biopsychosocial-spiritual factors on medication adherence in chronic diseases in Türkiye (Journal of Religion and Health, (2025), 10.1007/s10943-025-02317-3)(Kluwer Academic/Human Sciences Press Inc., 2025) Bilgin, Aylin; Döner, Ayser; Erdoğan Yüce, Gülyeter; Muz, GamzeCorrection to: Journal of Religion and Healthhttps://doi.org/10.1007/s10943-025-02317-3. In this article, the title was incorrectly given as ‘The Effect of Biopsychosocial-Spiritual Factors on Medication Adherence in Chronic Diseases in Turkey Using Structural Equation Modeling’ but should have been ‘The Effect of Biopsychosocial-Spiritual Factors on Medication Adherence in Chronic Diseases in Türkiye’.Öğe Polysaccharide-based edible and biodegradable films from Eruca vesicaria mucilage: structural characterization, biocompatibility, and environmental impact(Springer Science + Business Media, 2025) Koç Bilican, BehlülThis study reports the development and characterization of edible, biodegradable films based on Eruca vesicaria seed mucilage, enriched with leaf extract and seed oil. Structural, thermal, mechanical, and surface properties were analyzed using fourier transformed infrared spectroscopy, termogravimetric analysis, scanning electron microscopy, and water contact angle measurements. Functional performance was evaluated through mechanical testing, water vapor permeability, and biodegradability in soil and water. Antioxidant activity and biocompatibility were assessed via DPPH assay and cytotoxicity tests on L929 fibroblast cells. The incorporation of Eruca vesicaria extract and oil enhanced mechanical strength, thermal stability, and antioxidant capacity. EM-Oil films showed increased hydrophobicity and biocompatibility, indicating potential for food packaging and biomedical applications. In contrast, EM-Extract films exhibited high antioxidant activity (73.31%) and flexibility but adversely affected long-term cell viability. Biodegradation studies revealed significant degradation in soil within 30 days (25–45% weight loss). Overall, Eruca vesicaria-based films offer a sustainable and eco-friendly alternative to synthetic plastics. These findings support their potential use in active packaging, while future research should address formulation refinement and industrial-scale production.Öğe Does Zn-Mediated regulation of the Kynurenine Pathway provide the link between periodontal disease and diabetes(Springer, 2025) Afşar, Ebru; Doğan, Kadirhan; Arslan, Erdem; Eranil, Işıl; Oral, Neşe; Kuzzu, Kadir Bahadır; Ceylan, Tayfun; Öz, MehmetIt has long been known that there is a relationship between periodontal diseases and diabetes. The present study aimed to assess the effect of pancreatic zinc (Zn) levels on Kynurenin pathways (KP) and glucose homeostasis and the impact of Thymoquinone (TQ) in the periodontal disease animal model. Ten microliters of Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-Lps) (1 mg/ml) was injected at 48-h intervals into the palatal gingiva of rats, and TQ was given by oral gavage (10 mg/kg per day) for 2 weeks. Glucose homeostasis was assessed using the Homeostatic Model Assessment (HOMA-IR), and β-cell function (HOMA-β Levels). Kynurenine (KYN), Tryptophan (TRP), kynurenic acid (KYNA), quinolinic acid (QA), KYN 3-monooxygenase (KMO), kynureninase, interferon-γ (IFN-γ), insulin, ZIP10, and caspase-3 levels measured by the enzyme-linked immunosorbent assay (ELISA). Zinc levels in the pancreas tissue and plasma samples were measured using a colorimetric method. Morphological changes in the pancreas were identified by hematoxylin and eosin staining, and X-ray radiography determined bone resorption in the maxillary bone. In the LPS group, pancreas ZIP10 and Zn levels increased, the KP pathway was altered to favor KYNA, and impaired glucose homeostasis was observed. TQ administration decreased pancreatic Zn levels, changed KP to favor QA, and improved morphological changes in the pancreas. During the progression of periodontal diseases, KP may be altered by Zn levels through ZIP10 in the pancreas, thereby impairing pancreatic function. Regulation of Zn levels may be key to shared pathways between periodontal diseases and diabetes.Öğe The role of reit dividend policy on ex-ante portfolio allocation(Mendel University in Brno, 2025) İlbasmış, MetinTo test the diversification benefits of REIT sub-groups formed based on dividend payout ratios, we forecast ex-ante variance-covariance matrices using a rolling window correlation and a DCC model. Regression-based mean-variance spanning tests, mean-variance efficient frontiers, and a minimum variance portfolio allocation approach using ex-ante optimization frameworks are considered. A major finding of the current study is the dividend payout ratios of REITs affect REIT market diversification benefits. Apart from extending stock market index investors’ investment universe and providing more efficient (higher profitability and/or lower risk) portfolios, REITs offer diversification benefits directly related to dividend policies. A unique level of diversification is attained by classifying REITs based on their dividend payout ratios. As well, these REIT subgroups are capable of left-shifting the efficient frontier of a market portfolio with either of the REIT sub-groups.Öğe Preparing children for the future with environmental education(IGI Global, 2025) Yıldırım, BediaThe natural environment, which has been damaged by human interventions, was initially able to tolerate human-induced negative impacts, but over time this destruction has reached the dimension of environmental disaster. Although steps were taken to address environmental problems from time to time, the measures taken were not sufficient and environmental problems continued to increase. Considering that the easiest, permanent and economical way to solve problems is through education, education should be given importance in the fight against environmental problems. The prerequisite for a livable environment is to raise an environmentally sensitive generation. The first target should therefore be the critically important early childhood period. In order to invest in our future, it is necessary to increase children's contact with nature, to ensure that they love and protect nature, and to develop their attitudes and skills to contribute to nature. So what are the duties of families and educators in this regard, what can we do for a more ecological, sustainable and livable environment?.Öğe Early childhood teachers’ understanding and perceptions regarding early childhood education for sustainability(Taylor and Francis Ltd., 2025) Köklü Yaylacı, Hasret; Olgan, RefikaEco-school teachers who primarily incorporate the principles of Education for Sustainable Development (ESD) into their teaching practices serve as active agents of sustainable development, with the potential to foster sustainable behaviors from an early age. This study examined the understanding and perceptions of early childhood eco-school teachers regarding sustainability, sustainable development, Education for Sustainable Development (ESD), and Early Childhood Education for Sustainability (ECEfS). Focus groups and pre-/postconcept maps were used to gather data. The findings showed that while teachers viewed ECEfS as crucial for sustainable development, their understanding of sustainability, sustainable development, and the goals of ESD and ECEfS was limited. Teachers predominantly associated ESD and ECEfS with the environmental pillar, though some acknowledged sociocultural and economic aspects. Moreover, key concepts for ECEfS practice involved respect for differences, saving, consumption habits, and self-confidence. In addition, teachers’ postconcept maps revealed a broader, more comprehensive understanding of ESD compared to their preconcept maps. These findings suggested that teachers needed professional development to enhance their knowledge and implementation skills for ECEfS and address the sociocultural and economic dimensions of sustainability to implement a holistic approach to ECEfS effectively.Öğe Data-driven drought prediction by means of machine learning techniques and ıncreasing accuracy with wavelet transform(Birkhauser Verlag Basel, 2025) Tuğrul, Türker; Selek, Bülent; Hınıs, Mehmet Ali; Selek, Zeliha; Oruç, SertaçDrought is not only a problem that challenges scientists but also one of the most difficult natural disasters to combat for local governments and decision-makers. Like many parts of the world suffering from drought, the western Mediterranean region of Turkey is also affected by drought. In this study, innovative drought prediction models were created with different machine learning algorithms and deep learning methods to create a model that will help decision-makers regarding drought. 4 different monthly lagged model structures were established using SPI12 values calculated with precipitation data between 1967 and 2020 for the Acipayam, Bodrum and Fethiye regions located in the west of Turkey. While providing data, attention was paid to the distance between stations and data continuity. The models were analyzed with Long-Short Term Memory (LSTM), Artificial Neural Network (ANN) and Random Forest (RF) algorithms. In addition, Discrete Wavelet Transform (WT) was used to obtain better model results. The hyper-parameters of these algorithms were determined by taking into account the most commonly used parameters in the literature. The analysis results were evaluated by correlation coefficient (R), root mean square error (RMSE), Nash–Sutcliffe Efficiency (NSE), and Combined Accuracy (CA). As a result of the comparison of these methods, the best results were obtained in the M01 model of LSTM, LSTM-WM01, for Acipayam after WT (r: 0.9910, NSE: 0.9733, RMSE: 0.1637, and CA: 0.1030). While the best prediction for Bodrum was obtained in LSTM-WM02 after WT (r:0.9657, NSE:0.9325, RMSE:0.3101, and CA: 0.1929), for Fethiye it was obtained in LSTM-WM02 having performance metrics r:0.9539, NSE:0.8973, RMSE:0.3689, and CA: 0.2359. It is expected that the results obtained with this study will help researchers and decision-making authorities on drought.Öğe The role of social capital for widowed women in their social service needs: protective or obstructive(Routledge, 2025) Öztürk, Hatice; Yıldırım, FilizWidows face psychological, economic, and social challenges after the loss of their spouse. To identify the social service needs of these women, it is essential to understand the relationships and interactions—beginning from childhood—that form the foundation of these issues. Social capital, the focus of these relationships, is defined as close, distant, and formal relationships based on trust and norms. This study aims to understand the role of social capital in the social service needs of widows in Turkey through their narratives. This narrative study with 20 widows aged 18–65 explores their narratives through in-depth interviews. Participants were selected through snowball sampling, and thematic analysis was conducted using MAXQDA, 2024. The results revealed the significance of trust in the relationships of widows, beginning from childhood, and demonstrated that social capital can play both supportive and obstructive roles in meeting their social service needs. Furthermore, the results can provide evidence for why social workers working with widows should focus on their relationships with close, distant, and formal networks when assessing them from a person-in-environment perspective. Future researchers may focus on gender, stigmatization, and rural–urban residency to examine the role of social capital in meeting widows’ social service needs.Öğe Lead-Free Cs2(Cd/Sn)BeCl6 Halide Double Perovskites: a comprehensive first-principles study of structural, optoelectronic, and thermoelectric properties for sustainable energy applications(John Wiley and Sons Inc, 2025) Benkatlane, Aissa; Rached, Djamel; Caid, Messaoud; Rached, Habib; Deligöz, Engin; Rached, Youcef; Özışık, Hacı; Mansour, Houda; Benkhettou, Nour-EddineAb initio simulations based on density functional theory are employed to investigate the structural, electronic, mechanical, optical, and thermoelectric properties of Cs2ABeCl6 (A = Cd, Sn) halide double perovskites. The results demonstrate that both compounds crystallize in the stable cubic Fm-3m symmetry. Structural and thermodynamic stability are verified through the Goldschmidt tolerance factor (tG), octahedral factor (μ), modified tolerance factor (τ), formation energies (ΔEf), and Born–Huang criteria. Mechanical property evaluations suggest ductility and significant anisotropy in both compounds. First-principles calculations using the generalized gradient approximation indicate a direct bandgap of 1.98 eV for Cs2CdBeCl6 and an indirect bandgap of 2.58 eV for Cs2SnBeCl6. Optical investigations reveal significant absorption, refractive index, extinction coefficient, energy loss spectra, and reflectivity features in the energy range of 0–13 eV, indicating strong interactions within the ultraviolet region. Thermoelectric properties are evaluated using the BoltzTraP code, revealing low thermal conductivities and figure of merit values close to 1 at room temperature, which demonstrates excellent thermoelectric performance. The synergy of semiconducting behavior, strong UV absorption, and high thermoelectric efficiency positions Cs2CdBeCl6 and Cs2SnBeCl6 as promising candidates for optoelectronic and energy applications. This work presents the first theoretical investigation of beryllium-containing double perovskites, combining beryllium's unique mechanical stability with optoelectronic functionality.Öğe First report on the ısolation of salmonella enterica subsp. enterica serovar hofit in wild boars (sus scrofa) in Türkiye(Mary Ann Liebert Inc., 2025) İlhan, Ziya; Hasdoğan, Harun; Gökmen, MukadderatThe aim of this study was to isolate potential bacterial pathogens, such as Salmonella spp., from wild boars (Sus scrofa) inhabiting the Southern Marmara Region of Turkiye and to evaluate the in vitro antibiotic susceptibility of the isolates. Samples, including feces and internal organs (lymph nodes, liver, lungs, kidneys, and spleen), were collected from a total of 34 legally hunted wild boars. Salmonella enterica subsp. enterica serovar Hofit was isolated from 6 (17.6%) animals. Ciprofloxacin, streptomycin, ampicillin, tetracycline, chloramphenicol, enrofloxacin, gentamicin, ceftiofur, cefoxitin, nalidixic acid, amoxicillin/clavulanic acid, and trimethoprim/ sulfamethoxazole discs were used to determine the in vitro antimicrobial susceptibility of S. Hofit isolates. All S. Hofit isolates had 100% sensitivity to 11 of the antibiotics tested, and three isolates were resistant only to streptomycin. As a result, this study is the first to report the isolation of S. Hofit from wild boars worldwide. The high isolation rate (17.6%) suggests a potential adaptation of this serovar to swine hosts. The apparent prevalence of S. Hofit in wild boars raises concerns not only for wildlife but also for potential public health implications.Öğe The effect of cherry laurel, rutin flavonoid and α-lipoic acid on streptozotocin and nicotinamide ınduced type 2 diabetic rats given metformin(Springer International Publishing, 2025) Kaya Kartal, Yeliz; Pekcan, Mert; Ahlat, Ozan; Özkurt, Güzin; Kısmalı, Görkem; Gönenç, Aymelek; Sel, TevhideType 2 diabetes, characterized by insulin resistance, is a growing global health concern. The combined use of pharmaceutical medications and natural products for diabetes has become more common in recent years, although it is still unresolved how they might interact. This study aims to investigate the interactive effects of metformin and natural antioxidants—cherry laurel, rutin flavonoids, and α-lipoic acid—on metabolic and histological outcomes in a type 2 diabetes model. Six rat groups were used, five of the groups rendered diabetic using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg, i.p.). For 12 weeks, animals received oral doses of metformin (500 mg/kg) and the combinations of metformin and natural products. Serum was analyzed for glucose, lipid profile, ceruloplasmin, plasma for nitric oxide and pancreatic tissue for histopathological changes and, insulin immunoreactivity. Ceruloplasmin levels were significantly higher in diabetic rats (22.89 ± 2.85 U/L) compared to the diabetic + metformin + rutin group (14.32 ± 0.73 U/L). Nitric oxide levels were lower in diabetic rats (61.27 ± 6.26 µmol/L) but elevated in the metformin-only group (110.22 ± 11.44 µmol/L). Histopathological evaluation showed pronounced pancreatic atrophy in the diabetic, diabetic + metformin + cherry laurel, and diabetic + metformin + rutin groups, while the diabetic + metformin group exhibited preserved tissue. Interestingly, insulin secretion was lower in the combination therapy groups (especially the use of rutin flavonoid and α-lipoic acid) compared with the control and diabetic + metformin group, suggesting potential antagonistic effects. Although glucose levels were not markedly different across treatment groups, histological findings revealed more pronounced tissue damage in antioxidant-metformin combinations than with metformin alone. These results highlight the importance of evaluating natural product–drug interactions before co-administration.Öğe Correction to: exposure to an electromagnetic field during adolescence can cause destruction and pain in bone tissue and cells while also triggering new bone formation (bratislava medical journal, (2025), 10.1007/s44411-025-00217-2)(Springer International Publishing, 2025) İkinci Keleş, Ayşe; Kaya, Haydar; Keleş, Gökhan; Tümkaya, LeventWhen this article was published, the name of the 3rd author was wrongly given as “Gökhan İkinci Keleş” though it should be correctly “Gökhan Keleş”. The Original article has been corrected. The Publisher apologises for this mistake.Öğe Prognostic value of the hemoglobin, albumin, lymphocyte, platelet score in metastatic mesothelioma: a retrospective study(S. Karger AG, 2025) Doğan, Özlem; Düzköprü, Yakup; Eren, TülayMalignant mesothelioma is a rare but aggressive cancer with limited treatment options and poor prognosis. Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score, reflecting inflammation and nutritional status, is a potential prognostic marker in various cancers. Our study aimed to investigate the prognostic value of the HALP score in mesothelioma. Methods: This retrospective study included 68 metastatic mesothelioma patients diagnosed between 2015 and 2023. Clinical and laboratory data were collected, and HALP scores were calculated at the time of metastasis. Patients were divided into HALP-low and HALP-high groups based on the median HALP score. Overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method, and prognostic factors were assessed using univariate and multivariate analyses. Results: The median HALP score was 24.85. The median OS for the entire cohort was 11.59 months. Patients with low HALP scores had significantly worse OS (7.81 months) compared to those with high HALP scores (16.36 months) (p = 0.01). Similarly, median PFS was significantly shorter in the HALP-low group (7.29 months) compared to the HALP-high group (12.12 months) (p = 0.02). In multivariate analysis, low HALP score (p = 0.02) and de novo metastatic disease (p = 0.01) remained independent prognostic factors for OS. Conclusion: This study demonstrates that the HALP score is an independent prognostic biomarker in metastatic mesothelioma. Low HALP scores are associated with worse OS and PFS. Given its simplicity and cost-effectiveness, the HALP score may be a valuable tool for risk stratification and treatment decision-making in clinical practice.Öğe Advancing the thermodynamic approach with the predictive model for the freeze-drying of meat(Frontiers Media SA, 2025) Öztuna Taner, ÖznurThe establishment of innovative engineering techniques for meat products is required because of the significant energy requirements associated with freeze-drying of food products. This study is innovative application research on the freeze-drying of meat process and analyses energy efficiency by employing predictive statistical methods. Thermodynamic laws play a crucial role in the thermodynamic analysis of frozen food processes by regulating the essential operations involved in food production. The thermodynamic evaluation of the freeze-drying of meat process was carried out over a total of 40 scenarios covering 24 h (20 scenarios) and 30 h (20 scenarios). The energy efficiency in the 24 h process fluctuated between 38.7 and 43.1% over the 20 scenarios, whereas in the 30 h process, it varied from 36.9 to 41.1% throughout the 20 scenarios. The analysis revealed that the energy efficiency of the 24 h scenarios exceeded that of the 30 h scenarios, suggesting that 24 h is the optimum period for meat drying. This comparative assessment indicates that shortening the drying duration can deliver substantial energy savings without compromising process effectiveness. Future research will look at the application of this technology to enhance food quality and shelf life by applying a comparable freeze-drying technique to meat in various food industries.Öğe Pb2CoMoO6 as a promising energy material: a first-principles perspective(Springer New York, 2025) Caid, M.; Deligöz, Engin; Rached, D.; Rached, H.; Mansour, H.; Özışık, H.; Rached, Y.This study presents a detailed first-principles investigation of the structural, elastic, electronic, optical, and thermoelectric properties of the double perovskite Pb2CoMoO6 compound. The calculations were carried out the full-potential linearized augmented plane wave (FP-LAPW) method within the framework of density functional theory (DFT). We evaluated the energetic stability, the Goldschmidt tolerance factor (tG), octahedral factor (µ), and modified tolerance factor (τ), formation energy (ΔHf), cohesive energy (Ecoh), phonon dispersion and mechanical characteristics. The findings confirm that Pb2CoMoO6 crystallizes in a perfectly cubic structure belonging to the Fm-3 m space group. Mechanical analysis indicates high elasticity and strength as evidenced by high mass and Young’s moduli, which indicative the stability of the material. The electronic structure calculations reveal half-metallic ferromagnetic (HMF) behavior, with a spin-up band gap of 1.558 eV along the L-Γ direction under the GGA + U approach. Additionally, the compound exhibits an integer magnetic moment of 3.0 µB per formula unit. Moreover, Pb2CoMoO6 exhibits strong optical absorption in the ultraviolet (UV) spectrum and displays promising thermoelectric behavior, with favorable Seebeck coefficients and a high figure of merit (ZTmax≈1) at room temperature, suggesting potential for applications in spintronic and thermoelectric devices.Öğe A novel poly(vinyl N-furfuryl-N-benzoylthiourea) and its metal complexes: synthesis, properties, and food packaging applications(Springer Verlag, 2025) Kurt, Gülşah; Erdem, Nuran; Ünlü, Burhan4-vinyl-N-furfuryl-N-benzoylthiourea monomer (4VBT1) was successfully polymerized using free radical polymerization conditions with high yields and molecular weights, Mn = 674 kDa with 2.0 molecular weight distribution (PDI). Ag(I), Zn(II) and Cu(II) complexes of this polymer have also been successfully synthesized and characterized. The films of polymer (P4VBT1) and its silver complex (P4VBT1-Ag) were evaluated to determine their food preservation properties. Physicochemical and microbiological analyses of the packaged beef with P4VBT1 and P4VBT1-Ag films were carried out on the 1st, 5th, 10th, and 14th days of the storage process. Moisture levels in P4VBT1 and P4VBT1-Ag stayed stable, and no significant pH difference was detected between the groups at the end of the storage period. The beef’s peroxide in P4VBT1-Ag packaging was lower than others at storage end. During storage, insignificant changes were observed in a* values for group B and b* values for groups A (P4VBT1) and B (P4VBT1-Ag). Throughout the storage period, group B demonstrated the lowest levels of total mesophilic aerobic bacteria (TMAB) and total psychrotrophic aerobic bacteria (TPAB). On day 14, it also had the fewest Escherichia coli, but samples showed no statistical difference. By day ten, P4VBT1 and P4VBT1-Ag packaging showed reduced effectiveness in suppressing Coliform bacteria. Utilizing P4VBT1 and P4VBT1-Ag materials for packaging has led to a slowdown in microbial expansion.Öğe PSO based TCN hybrid optimization for turbulent heat transfer prediction of multiple synthetic jets in crossflow(Springer Nature, 2025) Akçay, Selma; Buyrukoğlu, Selim; Akdağ, Ünal; Güngör, BekirThe development of artificial intelligence (AI) models offers significant advantages in laborious, expensive, and long-term experimental and numerical studies. Therefore, AI methods have recently attracted considerable attention in different engineering applications. In the present work, the heat transfer performance of multiple synthetic jets immersed in crossflow on a flat target surface was researched experimentally and estimated with different deep learning models (LSTM, BiLSTM, CNN, GRU, and TCN) and particle swarm optimization (PSO). In the experiments, the effects of the main flow Reynolds number (6000 ≤ Re ≤ 40,000), oscillation amplitude (0.22 ≤ Ao ≤ 0.88), and Womersley number (11 ≤ Wo ≤ 27) on the cooling performance were analyzed. The Nusselt number (Nu), friction factor (f), and thermohydraulic performance (THP) were calculated for different flow and jet parameters. The results showed that for Re = 6000, Wo = 27, and Ao = 0.88, the synthetic jet improved the heat transfer by 2.74 times compared with the steady flow. The THP values increase with increasing synthetic jet parameters, and the highest THP is found 2.06 for Re = 6000, Wo = 27 and Ao = 0.88. Among the deep learning models based on experimental data, the TCN algorithm performed the best when optimized with PSO on data processed by COPULA. Compared with the other deep learning models, the hybrid TCN-PSO model achieves lower MAEs for Nu (5.68561), f (0.00725), and THP (0.0356). This research indicates that integrating deep learning with optimization methods is highly effective for designing models of dynamic thermal systems.Öğe Investigating the effects of carvacrol in isoproterenol-induced myocardial injury: Role of H-FABP and Gal-3/TLR4/MYD88/NF-κB signaling pathway modulation(Springer International Publishing, 2025) Küçükler, Sefa; Çomaklı, Selim; Özdemir, Selçuk; Değirmençay, Şükrü; Kandemir, Fatih Mehmet; Genç, Aydın; Dalkılınç, Elif; Aydın, ŞeymaThis study aimed to investigate the protective effects of carvacrol (CRV) on isoproterenol (ISO)-induced myocardial injury, focusing on its modulation of the Gal-3/TLR4/MYD88/NF-κB pathway. Thirty-five male Sprague Dawley rats were divided into five groups: control, CRV-treated, ISO-induced, and CRV pre-treated with two different doses (ISO + CRV 25 mg/kg and ISO + CRV 50 mg/kg). Cardiac markers, inflammatory cytokines, oxidative stress parameters, antioxidant enzymes, apoptosis, oxidative DNA damage, and endoplasmic reticulum (ER) stress were assessed. The study explored the impact of CRV on galectin-3 and the TLR4/MYD88/NF-κB pathway. ISO-induced myocardial injury was associated with elevated cardiac marker enzymes, inflammatory cytokines, oxidative stress, ERS, and activation of the Gal-3/TLR4/MYD88/NF-κB pathway. CRV treatment significantly attenuated these effects, showcasing its cardioprotective potential. Histopathological examination revealed reduced inflammatory cell infiltration with CRV pre-treatment. Furthermore, CRV significantly reduced oxidative stress parameters, including malondialdehyde (MDA) levels, and increased antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). The study highlighted the protective role of CRV against oxidative DNA damage, as indicated by decreased 8-OHdG levels. Additionally, CRV mitigated ERS by reducing ATF6 and GRP78 expression levels. It was also determined that CRV reduces apoptosis by regulating the expression levels of Bax (Bcl-2-associated X protein) and Bcl-2 (B-cell lymphoma 2), as well as AKT (Protein kinase B) protein levels. This comprehensive understanding underscores CRV's potential as a promising therapeutic agent for managing myocardial injury, providing valuable insights into its broader effects on cardiovascular health.Öğe Assessment of p-wave dispersion and atrial electromechanical delay in patients with non-obstructive coronary artery myocardial infarction(Springer International Publishing, 2025) Keleşoğlu, Şaban; Yılmaz, Yücel; Elçik, Deniz; İnci, Sinan; Gül, Murat; Kalay, NihatWe investigated p-wave dispersion (Pd) and atrial electromechanical delay (EMD) in patients diagnosed with non-obstructive coronary artery disease and myocardial infarction (MINOCA). Background: The clinical importance and recognition of MINOCA are increasing. However, there is a gap in knowledge regarding the risk of atrial fibrillation in patients with MINOCA. Methods: Forty-three patients with MINOCA (average age 48.69 ± 5.83 years) and thirty-four patients with non-obstructed coronary artery disease (INOCA) (average age 49.82 ± 10.22 years) were enrolled in the study. Echocardiographic studies were conducted in the MINOCA and INOCA groups in the left lateral decubitus position using a medical ultrasound device. Atrial electromechanical coupling (PA) and intra-atrial and interatrial EMD were measured using tissue Doppler echocardiography. Pd was measured using 12-lead electrocardiography. Results: Clinical and demographic characteristics were similar between groups. The maximum P-wave (Pmax) time and Pd values of patients diagnosed with MINOCA were significantly longer than those of patients diagnosed with INOCA (Pmax times: 109.72 ± 7.09 ms and 95.17 ± 7.50 ms, respectively, p < 0.01; Pd: 47.30 ± 8.99 ms and 34.14 ± 11.31 ms, respectively, p < 0.01). Tissue Doppler Imaging (TDI) revealed significantly longer atrial EMD parameters (PA lateral and PA septum) in patients diagnosed with MINOCA than in those diagnosed with INOCA (69.60 ± 8.79 ms and 57.08 ± 11.54 ms, respectively, p < 0.01; 54.83 ± 6.45 ms and 45.35 ± 8.50 ms, respectively, p < 0.01). Conclusion: This study showed that the duration of atrial EMD and Pd was prolonged in patients with MINOCA, suggesting a potential susceptibility to atrial conduction abnormalities.Öğe Pedogenic evidence sheds light on the post-Roman pedo-sedimentological and human history of Tarsus, the Roman capital of CE 60, Cilicia, Mersin, Türkiye(Elsevier B.V., 2025) Kapur, Selim; Akça, Erhan; Kadir, Selahattin; Previtali, Franco; Billor, Zeki; Zucca, Claudio; Casati, Enrico; Eren, Muhsin; Karagöz, AlptekinThe ancient city of Tarsus is underlying a sediment of 400 cm where the contemporary Tarsus grew. The diffusely stratified layers of the deposited sediment from the Kydnos (Tarsus) river overlying the Roman Road excavation site located in the heart of the modern city. The sediment is laden with technogenic materials. The profile of the stratigraphic layers represents a Pedocomplex (PDC) and its horizons are the Pedomembers (PDMs). All the PDMs were described and sampled for physical, chemical, mineralogical, micromorphological, and thermoluminescense analyses seeking pedogenic evidences. The origin of PDC materials is a fluvial and/or lagoon environment (archaeologically predicted date, about 60 CE, and they are calcareous, high in available P and some are high in total phosphorus contents). They have been partially modified by human activity in a settlement area, thus bringing some historical evidence suggesting that the site was part of the growing city after its abandonment. Thin sections show a vigorous biological degradation of the organic residues in the PDMs along with occasional evidence of soil-forming processes. The preliminary conclusions were extracted from the results obtained through the newly formed hydroxyapatite (Hap) determined by micromorphology, therefore proposing the new suffix π for the WRB soil naming system. Primary, high temperature and clay minerals together with TL analyses of the layers, were conducted to reveal the provenance and weathering phases of the horizons. The seeds recovered from an inhabited layer helped to interpret the food and medicinal habits of the local society and the contemporary presence of the lagoon.
