Antioxidative, antimicrobial and cytotoxic properties of Isatis floribunda Boiss. ex Bornm. extracts

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dc.contributor.authorKarakoca, Kübra
dc.contributor.authorAşan Özüsağlam, Meltem
dc.contributor.authorÇakmak, Yavuz Selim
dc.contributor.authorErkul, Seher Karaman
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:23:05Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:23:05Z
dc.date.issued2013
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe Isatis species has antibacterial, anticancer and antiviral properties and these important endemic plants grow widely in various parts of Anatolian-Turkey. In the present study, the antioxidant activities of Isatis floribunda Boiss. ex Bornm. flower and root extracts were determined with total antioxidant activity, free radical scavenging activity, ferric ion reducing power, and cupric ion reducing antioxidant capacity assay. The total phenolic compounds and flavonoids were also examined for the extracts. The antimicrobial activities of the extracts were investigated by using the disc diffusion and microdilution-broth methods against human and fish pathogen microorganisms. The phenolic composition of I. floribunda root methanolic extract was analyzed by high performance liquid chromatography (HPLC). The major component in the extract was cholorogenic acid (1980.20 µg/g). The cytotoxic effect of the methanolic root extract was also tested on human breast cell (MCF12A). The results showed that I. floribunda could be used as a natural source in the food and feed industry and clinical and food chemistry, and that the antimicrobial agents could be used against human and fish pathogens.
dc.identifier.endpage167en_US
dc.identifier.issn1611-2156
dc.identifier.scopusqualityQ1
dc.identifier.startpage150en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2700
dc.identifier.volume12en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofEXCLI Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectClinical/Food Borne Pathogens
dc.subjectCytotoxic Activity
dc.subjectFish Pathogens
dc.subjectHPLC
dc.titleAntioxidative, antimicrobial and cytotoxic properties of Isatis floribunda Boiss. ex Bornm. extracts
dc.typeArticle

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