Carvacrol Coadministration Ameliorates Lambda-Cyhalothrin-Induced Peripheral Neuropathy in Rats: Behavioral and Molecular Evidence

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dc.authorid0000-0002-4581-4492
dc.authorid0000-0001-6775-7858
dc.authorid0000-0003-2508-8558
dc.contributor.authorKandemir, Özge
dc.contributor.authorİleriturk, Mustafa
dc.contributor.authorGür, Cihan
dc.contributor.authorAkaras, Nurhan
dc.contributor.authorŞimşek, Hasan
dc.contributor.authorYılmaz, Selçuk
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2025-07-23T08:28:29Z
dc.date.available2025-07-23T08:28:29Z
dc.date.issued2025
dc.departmentTeknik Bilimler Meslek Yüksekokulu
dc.description.abstractThis study aimed to investigate the possible neuroprotective effects of Carvacrol (CRV) against Lambda-cyhalothrin (CYH)-induced peripheral neuropathy. Thirty-five rats were divided into five groups: Control, CRV, CYH, CYH+CRV25, and CYH+CRV50. CRV 25 or 50 mg/kg and CYH 6.23 mg/kg were administered orally for 21 days. The effects of these treatments were evaluated by hot plate and rotarod tests, followed by molecular, biochemical, histopathological, and immunohistochemical analyses of sciatic nerve tissues. CYH administration significantly impaired both sensory and motor functions. CRV doses (25 mg/kg and 50 mg/kg) administered with CYH significantly improved these impairments (p < 0.001). Additionally, CYH increased MDA levels and decreased antioxidants, while CRV treatment reversed these effects. CRV also suppressed inflammation (p < 0.01), apoptosis (p < 0.001), and endoplasmic reticulum stress (p < 0.001), with the 50 mg/kg dose being more effective. Morphological and immunohistochemical analyses showed that CRV treatment partially repaired CYH-induced nerve damage, with both doses reducing 8-OHdG and beclin-1 immunoreactions. The data revealed that CYH induced inflammation, oxidative stress, ER stress, and apoptosis in sciatic tissue, while CRV exhibited antioxidant, anti-inflammatory, and antiapoptotic effects, reducing the damage and suggesting its potential as a supportive treatment for CYH-induced sciatic damage.
dc.identifier.doi10.1002/jbt.70400
dc.identifier.issn1095-6670 / 1099-0461
dc.identifier.issue7
dc.identifier.pmid40662443
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.70400
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13535
dc.identifier.volume39
dc.identifier.wosWOS:001528990500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorKandemir, Özge
dc.institutionauthorAkaras, Nurhan
dc.institutionauthorŞimşek, Hasan
dc.institutionauthorKandemir, Fatih Mehmet
dc.institutionauthorŞimşek, Hasan
dc.institutionauthorid0000-0001-8884-4168
dc.institutionauthorid0000-0002-8457-9448
dc.institutionauthorid0000-0001-5573-4923
dc.institutionauthorid0000-0002-8490-2479
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarvacrol
dc.subjectCyhalothrin
dc.subjectOxidative Stress
dc.subjectPeripheral Neuropathy
dc.subjectSciatic Nerve
dc.titleCarvacrol Coadministration Ameliorates Lambda-Cyhalothrin-Induced Peripheral Neuropathy in Rats: Behavioral and Molecular Evidence
dc.typeArticle

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