An investigation of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in dogs with canine distemper
| dc.contributor.author | Değirmençay, Şükrü | |
| dc.contributor.author | Camkerten, Güzin | |
| dc.contributor.author | Camkerten, İlker | |
| dc.contributor.author | Aktaş, M. Sinan | |
| dc.date.accessioned | 2021-04-28T10:18:15Z | |
| dc.date.available | 2021-04-28T10:18:15Z | |
| dc.date.issued | 2021 | |
| dc.department | Veteriner Fakültesi | |
| dc.description | *Camkerten, Güzin ( Aksaray, Yazar ) *Camkerten, İlker ( Aksaray, Yazar ) | |
| dc.description.abstract | This study aimed to investigate the diagnostic value of thiol/disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) levels in evaluating oxidative stress in dogs with canine distemper. The study materials consisted of 24 cross-breed dogs: 18 dogs with canine distemper (CD group) and 6 healthy dogs as the control. Blood samples for analysis of antioxidant-oxidant parameters were taken from both groups. In addition to TDH parameters (native thiol [NT], total thiol [TT], and disulfide [Ds] levels and Ds/NT, Ds/TT, and NT/TT ratios), IMA and albumin (ALB) levels were also determined in the blood serum of the groups. The IMA levels of the CD group were significantly higher than the control group (P<0.05). Antioxidant parameters (NT, TT) and oxidant parameters (Ds, Ds/NT, and Ds/TT) both exhibited a significant positive correlation among themselves (P<0.01). The areas under the ROC curve of IMA, Ds/NT, and Ds/TT were 0.78, 0.62, and 0.62 respectively. The high levels of IMA, Ds, Ds/NT, and Ds/TT and low levels of NT, TT, NT/TT and ALB in dogs with canine distemper can be used to assess the oxidative stress caused by the disease. Overall, the diagnostic performances of IMA. Ds/NT, and Ds/TT for detection of increased oxidative stress were similar, but IMA was superior. | |
| dc.identifier.doi | 10.24099/vet.arhiv.0867 | |
| dc.identifier.endpage | 49 | en_US |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.scopusquality | Q4 | |
| dc.identifier.startpage | 39 | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.24099/vet.arhiv.0867 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/7914 | |
| dc.identifier.volume | 91 | en_US |
| dc.identifier.wos | WOS:000621554500005 | |
| dc.identifier.wosquality | Q4 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | Zagrab University | |
| dc.relation.ispartof | Veterinarski Arhiv | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Canine Distemper | |
| dc.subject | Oxidative Stress | |
| dc.subject | Thiol/disulfide Homeostasis | |
| dc.subject | Ischemia-modified Albumin | |
| dc.title | An investigation of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in dogs with canine distemper | |
| dc.type | Article |
