An investigation of thiol/disulfide homeostasis and ischemia-modified albumin levels to assess the oxidative stress in dogs with canine distemper
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Zagrab University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study aimed to investigate the diagnostic value of thiol/disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) levels in evaluating oxidative stress in dogs with canine distemper. The study materials consisted of 24 cross-breed dogs: 18 dogs with canine distemper (CD group) and 6 healthy dogs as the control. Blood samples for analysis of antioxidant-oxidant parameters were taken from both groups. In addition to TDH parameters (native thiol [NT], total thiol [TT], and disulfide [Ds] levels and Ds/NT, Ds/TT, and NT/TT ratios), IMA and albumin (ALB) levels were also determined in the blood serum of the groups. The IMA levels of the CD group were significantly higher than the control group (P<0.05). Antioxidant parameters (NT, TT) and oxidant parameters (Ds, Ds/NT, and Ds/TT) both exhibited a significant positive correlation among themselves (P<0.01). The areas under the ROC curve of IMA, Ds/NT, and Ds/TT were 0.78, 0.62, and 0.62 respectively. The high levels of IMA, Ds, Ds/NT, and Ds/TT and low levels of NT, TT, NT/TT and ALB in dogs with canine distemper can be used to assess the oxidative stress caused by the disease. Overall, the diagnostic performances of IMA. Ds/NT, and Ds/TT for detection of increased oxidative stress were similar, but IMA was superior.
Açıklama
*Camkerten, Güzin ( Aksaray, Yazar ) *Camkerten, İlker ( Aksaray, Yazar )
Anahtar Kelimeler
Canine Distemper, Oxidative Stress, Thiol/disulfide Homeostasis, Ischemia-modified Albumin
Kaynak
Veterinarski Arhiv
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
91
Sayı
1
