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Öğe Feline Panleukopenia - Effects of Treatment with Filgrastim on Mortality, Hematological and Biochemical Parameters(Universidade Federal do Rio Grande do Sul, 2025) Uyurca, Tarık; Haydardedeoğlu, Ali EvrenPanleukopenia is a highly contagious and fatal disease of cats. Although infection may be prevented by intensive vaccination of animals in the home environment, infection is frequently seen in stray animals that are not vaccinated and are in contact with the virus. Treatment protocols in the disease consist of classical supportive therapies because there is no specific antiviral drug. The aim of this study is to evaluate the effects of Filgrastim administration on mortality, complete blood count, and serum biochemical parameters in the treatment of cats infected with Feline Panleukopenia Viruses (FPV). Materials, Methods & Results: The study population consisted of 2-6 months old cats of different breeds and sexes who were brought to our clinic with complaints of lethargy, anorexia, high fever, diarrhoea and vomiting. A complete blood count was taken from the symptomatic patients during physical examination and FPV Ag test was performed. Fourteen cats with positive FPV antigen test and 7 healthy cats with negative FPV Ag test without clinical symptoms were included in the study. The study included 7 Panleukopenia-infected cats treated with Filgrastim in addition to conventional supportive therapy, 7 Panleukopenia-infected cats treated with conventional supportive therapy, and 7 healthy cats. Complete blood count and serum biochemical parameters were analyzed from the samples taken from the patients on days 0, 3 and 7. As a result of the treatment, the mortality rate was 14.28% in both groups. In this study, it was observed that the administration of Filgrastim (Group 1) had statistically significant results on WBC (P < 0.009), lymphocytes (P < 0.009) and granulocytes (P < 0.003) between days 0 and 7 in cats with FPV. This suggests that the administration of Filgrastim in addition to supportive therapy increases the number of lymphocytes and granulocytes. The administration of Filgrastim as an adjunct to supportive therapy had no effect on the serum biochemistry values of the patients. In conclusion, the administration of Filgrastim in the treatment of panleukopenia did not result in a change in the mortality rate. Discussion: The incidence of FPV decreases as the age of the animal increases. In cats aged 3-5 months, the amount of antibody from the mother decreases. In this study, it was determined that the age of all FPV Ag positive cats included in group 1 and group 2 was 2-6 months. It has been reported that there may be a rapid increase in neutrophil counts in cats with FPV treated with filgrastim. In this study, it was observed that the use of Filgrastim (Group 1) in cats with FPV produced statistically significant results on WBC, lymphocytes and granulocytes between days 0 and 7. This shows that the use of Filgrastim in addition to supportive therapy increases the number of lymphocytes and granulocytes. The incidence of FPV decreases as the age of the animal increases. In cats aged 3-5 months, the amount of antibody from the mother decreases. In this study, it was determined that the age of all FPV Ag positive cats included in group 1 and group 2 was 2-6 months. Serum biochemistry parameters are not specific for FPV. Hypoalbuminaemia is the most common abnormality, probably due to decreased protein intake and leakage from mucosal lesions into the gastrointestinal tract. Similar to the literature, no significant change was observed in biochemical parameters. In addition, serum biochemical examinations have shown that Filgrastim can be administered to cats without any side effects. Before administering an immune modulator such as G-CSF, the stage of the disease and the status of the immune system should be taken into consideration.Öğe Diagnostic importance of serum neopterin, procalcitonin and some acute phase proteins in cattle with lung hydatid cyst(Hellenic Veterinary Medical Society, 2025) Akyüz, E.; Aydın, U.; Merhan, O.; Karakurt, E.; Sezer, M.; Batı, Y.U.; Yıldız, U.; Nuhoğlu, H.; Erkılıç, E.E.; Ölmez, N.; Özaydın, İ.; Gökçe, G.; Erdoğan, H.M.In this study, it was aimed to determine the diagnostic importance of serum neopterin, procalcitonin, and some acute phase proteins in cattle with lung hydatid cysts. In the study, 30 cattle aged 2-8 years, Simmental or crossbred, constituted the patient group, and 10 healthy cattle in the same characteristics and age range constituted the control group. The cattle were included in the study after being diagnosed with lung hydatid cyst as a result of clinical, anamnesis, auscultation, radiographic examinations, laboratory and histopathological findings. Neopterin (21.60 nmol/L) and procalcitonin concentrations (146.77 ng/L) were significantly increased in the disease group compared to the control group (respectively: 7.22 nmol/L, 47.76 ng/L) (P<0.001). Haptoglobin (P<0.001) and ceruloplasmin (P=0.047) of the acute phase proteins werehigher in the patient group compared to the control group, while albumin was found to be lower (P=0.028). In conclusion, the evaluation of serum neopterin, procalcitonin, and some acute phase proteins in cattle with lung hydatid cysts was found to be important. Since hydatid disease is a zoonotic disease, it will be important to perform radiography scans and confirm the diagnosis with relevant biomarkers and take new protective measures. We think that the diagnosis will be strengthened by investigating neopterin and procalcitonin levels, especially in cattle with suspected lung cysts in radiographic findings.Öğe Radiographic cardiac indices for healthy New Zealand white rabbits: A reference interval study based on echocardiography(Ankara University, 2025) Kaya, Mahir; Çetinkaya, Mehmet AlperThis research was intended to identify reference intervals for the radiographic cardiac indices [vertebral heart scale (VHS), radiographic left atrial dimension (RLAD), and vertebral left atrial size (VLAS) of 58 healthy, adult New Zealand white rabbits based on echocardiography. The VHS, VLAS, and RLAD measurements were taken from contrast right lateral (R) and ventrodorsal (VD) thoracic radiographs. The correlations between these radiographic cardiac indices and echocardiographic parameters were then evaluated. The mean values with a reference interval were 7.94±0.31 vertebrae (v) (7.2-8.6 v) for R-VHS and 8.67±0.33 v (7.8-9.2 v) for VD-VHS. The median values with a reference interval were 1.5 v (1-2 v) for VLAS and 1 v (0.7-1.4 v) for RLAD. Body weight and gender had no effect on radiographic cardiac indices. There were positive correlations between all radiographic indices obtained from the R contrast radiographs and the echocardiographic parameters (rs≥0.421, P<0.0001). Excellent intraobserver agreement was determined for the radiographic measurement methods (intraclass correlation coefficients ≥0.818). The contrast thoracic radiography appears to represent a useful technique for the accurate determination of radiographic cardiac indices. The findings can be used as reference values for radiographic cardiac evaluation in both pet and laboratory rabbits.Öğe Prevalence and Molecular Characterization of Moniezia Species in Ruminants Based on ITS1-5.8S rRNA from Van Province, Turkey(University of Agriculture, 2025) Yılmaz, Ali Bilgin; Azizoğlu, Erkan; Adizel, Özdemir; Göz, Yaşar; Çelik, Burcak Aslan; Çelik, Özgür Yaşar; Ayan, Özge Oktay; Akhmetzhanova, Aizhan; Ayan, Adnan; Yasul, Muhammed; Myrzhiyeva, Assem; Uslu, UğurThis study aimed to calculate the occurence of Moniezia species in cattle, sheep, and goats in Van province and to identify these species using morphological and molecular methods (ITS1-5.8S rRNA gene region analysis). Additionally, the study aimed to identify the genetic differences between Moniezia expansa and Moniezia benedeni. During the summer of 2022, intestinal contents were collected from 150 ruminants (50 cattle, 50 sheep, and 50 goats) slaughtered in slaughterhouses in Van province. The parasites were examined using Aceto-Carmine staining, and species identification was based on interproglottidal glands. Examination of the intestinal contents revealed that 2 out of 50 cattle (4%), 14 out of 50 sheep (28%), and 9 out of 50 goats (18%) were infected with Moniezia. Morphological and molecular analyses showed that the cattle samples were identified as Moniezia benedeni, goats samples as Moniezia expansa and those from sheep as 11 Moniezia expansa and 3 Moniezia benedeni. Following DNA extraction, the ITS1-5.8S rRNA gene region was amplified using PCR and subjected to sequence analysis. The relationship between species was examined by phylogenetic tree. This study confirms the prevalence of Moniezia spp. in Van/Türkiye by using the ITS1-5.8S rRNA gene.Öğe Estrus synchronization using progesterone+different gonadotropins or flushing+ram effect in the breeding season in sheep(Biblioteca Universidad de Cordoba, 2025) Kırbaş, Mesut; Köse, Mehmet; Bülbül, Bülent; Dursun, Şükrü; Demirci, Uğur; Erduran, Hakan; Sarı, Deniz. The effect of different doses of Equine Chorionic Gonadotropin (eCG)or a dose of folliclestimulating hormone (FSH) in a progesterone-based estrus synchronization protocol or flushing+ram effect on fertility in the breeding season were examined on Konya Merino ewes. Materials and methods. Ewes were divided into six groups. Estrus of ewes in eCG-300, eCG-500, eCG-700, and FSH-10 groups was synchronized with an intravaginal sponge containing progesterone (Chronogest, 20 mg flugestone acetate, Intervet, Türkiye 20 mg)-derived for 12 days, and PGF2α injected one day before sponge removal. eCG-300, eCG-500, and eCG-700 groups received 300, 500, or 700 IU of eCG, respectively, at the time of PGF2α injection while FSH-10 group received 10 IU of FSH with sponge removal. In these four groups, estrus was detected for 5 days following sponge removal. Flushing+ram effect (F+RE) group ewes received dietary supplements for 28 days and ram effect for 14 days before the start of the mating period and were monitored for estrus for 4 weeks later. Control ewes monitored for estrus for two months without any treatment. Results. Birth rate was higher in F+RE group than eCG-500 and FSH-10 groups (p<0.05). Litter size was higher in eCG-700 group than F+RE and control groups (p<0.05). Fecundity was higher in eCG-700 group than FSH-10 group (p<0.05). Conclusions. 300 IU eCG at the end of progesterone application was sufficient to induce multiple lambing during the breeding season. Moreover, to increase lamb production should be taken necessary management measures for improve survival to weaning of multiple-born lambs.Öğe Promising Mesenchymal Stem Cell Intervention for Relieving Cardiac Recovery against Cardiotoxic Injury Modeling with Doxorubicin: A Novel Therapeutic Approach(Sciendo, 2025) Boztok Özgermen, Deva Başak; Haydardedeoğlu, Ali Evren; Yavuz, OrhanDoxorubicin (DOX), a commonly used anti-neoplastic agent, has been associated with significant cardiotoxic effects, which limit its clinical utility. Recent studies suggest that mesenchymal stem cells (MSCs) may offer therapeutic potential in mitigating DOX-induced cardiotoxicity through their regenerative properties. This study aimed to evaluate the cardioprotective effects of fetal kidney-derived mesenchymal stem cells (FKD-MSCs) in a DOX-induced cardiotoxicity rat model. Thirty male Sprague-Dawley rats were divided into three groups: control, sham, and treatment. DOX (10 mg/kg) was administered to the sham and treatment groups to induce cardiotoxicity. The treatment group received intraperitoneal FKD-MSCs (2 × 106) three times at weekly intervals post-DOX administration. Immunohistochemical analyses were conducted to assess cardiac recovery. The 5-bromo-2-deoxyuridine (BrdU) labeling technique was used to track FKD-MSC localization in the cardiac tissue. The immunohistochemical findings demonstrated a significant improvement in the treatment group compared to the sham group. The BrdU-labeled FKD-MSCs were predominantly localized in cardiac muscle tissues, indicating their successful homing and integration into damaged cardiac regions. The results of the study indicate that FKD-MSCs significantly attenuated DOX-induced cardiotoxicity in rats, suggesting their potential as a novel therapeutic approach for cardioprotection. Further studies are warranted to investigate their clinical applications in managing chemotherapy-induced cardiotoxicity.Öğe Keratoconjunctivitis sicca in intact Aksaray Malakli breed dogs: Evaluation of 50 cases(John Wiley and Sons Inc, 2024) Avcı, Nihan; Gümüş, Fehmiye; Boztok Özgermen, Başak; Özen, DoğukanKeratoconjunctivitis sicca (KCS) is characterized by decreased aqueous tear film components, leading to ocular surface damage. Diagnosis involves clinical examination, Schirmer Tear Test (STT1), and Tear Film Break-Up Time (TFBUT) measurement. This retrospective study aimed to assess dry eye syndrome in intact, purebred, Aksaray Malakli breed dogs, and investigate potential associations with hereditary ocular diseases due to inbreeding for phenotype preservation. Animals: Fifty healthy, purebred, intact Aksaray Malakli dogs of varying ages and sexes, all exhibiting conjunctival hyperemia and mucoid ocular discharge. Dogs with chronic diseases, systemic medication, or ongoing ophthalmic treatment were excluded. Procedures: Demographic data, ophthalmic examination results, and ocular anomalies were recorded. STT1 and TFBUT assessments were performed to measure tear production and film stability. STT1 values were scored from 1 (normal) to 4 (severe dry eye), and TFBUT ≥20 s was considered normal. Statistical analyses were used to evaluate correlations and differences. Results: The correlation between age and STT1 values (r = −.182, p =.206) was not statistically significant. Mean STT1 was higher in females than males, though not significantly (p =.849). Dogs without third eyelid gland prolapse had significantly higher STT1 and TFBUT measurements compared to those with prolapse (p =.027). No significant sex difference was found in the frequency of third eyelid prolapse (p =.289). A significant positive correlation was observed between STT1 and TFBUT (r =.924; p <.001). Conclusions: Aksaray Malakli dogs, particularly those with third eyelid gland prolapse, are predisposed to mild to moderate KCS. These findings suggest the need for further clinical and genetic investigations to better understand and manage dry eye syndrome in this breed.Öğe Relationship between blood antioxidant paraoxo-nase-1 and the offspring yield in hair goats(Trakia University, 2024) Dursun, ŞükrüSmall ruminants bring unproductive pastures to the economy with products such as meat and milk. Although the management of Hair goats is difficult compared to that of sheep, they make better use of unproductive pastures than sheep. The birth rate of Hair goats is high, but the multiple birth rate is quite low. This study aimed to determine the relationship between the antioxidant paraoxonase-1 (PON-1), and the offspring yield in Hair goats. In the second week of September, 100 females were randomly selected and blood samples were taken 15 days before the introduction of male goats to the herd from both males and females. Blood was taken from the same animals again before starting milk-ing in May. Paraoxonase-1 values were found to be low and significantly different in both sexes in October compared to May. There was a statistical difference (P?0.05) in PON-1 level in terms of gender and birth type. The PON-1 level of Hair goats that gave birth to twins was like that of male goats and goats with single birth, while it was insignificant between single-birth and infertile goats. It was found that a low PON-1 value was associated with low fertility whereas twin births were closely related to high value of PON-1. PON-1 was found to be important for multiple births (P?0.05). As a result, it was concluded that the PON-1 level increased the birth rate and offspring yield in Hair goats.Öğe Primary bone tumors in dogs and cats: 98 cases(Veteriner Hekimler Derneği, 2024) Filikci, Kürşat; Sağlam, Mehmet; Kutsal, Osman; Tunc, Arda SelinThe aim of this study is to contribute to the current literature by determining the distribution of bone tumors in dogs and cats by breed, age, gender and location. Bone tumors are more common in dogs than cats, and the most common primary bone tumor in both species is osteosarcoma. The biopsy and necropsy reports of the Ankara University, Faculty of Veterinary Medicine, Department of Pathology , were retrospectively studied examining for cases of primary bone tumors in dogs and cats. This study's period encompassed from 2001 through 2020 (20 years). A total of 98 bone tumors were detected 70 in dogs and 28 in cats. Of the cases in dogs, 13 (18.57%) were necropsy, while 57 (81.43%) were biopsy. Sex distribution of bone tumors is in female dogs (n:28, 40%) and in male dogs (n:38, 54.29%). Also, females (n:17, 60.7%) and males (n:11, 39.3%) were observed in cats. in dogs, although 57.14% (n=40) were purebreds and 31.43% (n=22) were mongrel breeds, in cats, 75% of them were mongrel (n=21) and 7.1% (n=2) were purebred. While locations of tumors in dogs were appendicular (65.71%, n=46), axial (30%, n=21), locations of tumors in cats were appendicular (50%, n=14), axial (39.29%, n=11) and both appendicular and axial (10.71%, n:3). While 13 benign (18.57%) and 57 malignant (81.43%) tumors were observed in dogs, 4 benign (14.29%) and 24 malignant (85.71%) tumors were observed in cats. The data were analyzed in the SPSS program and no significant relationship was detected between the data (P>0.05). This study would contribute and conduce the comparative oncology for dogs and cats.Öğe A review of surgical cases of newborn calves.(Ebubekir CEYLAN, 2024) Avcı, Nihan; Gümüş, Fehmiye; Boztok Özgermen, Başak; Sağlam, MehmetThis study aimed to retrospectively evaluate the diseases of calves. Surgically encountered diseases, causes, indicated treatment methods, and possible complications were evaluated and it was thought to contribute to scientific and clinical studies on this subject. Material-Method: The material of this study consisted of a total of 150 calves of different breeds, ages, and sexes brought to Aksaray University Faculty of Veterinary Medicine Animal Hospital Surgery Clinic between December 2017 and 2023 due to various problems. Result: In terms of surgical diseases, 37.3% of 150 calves were soft tissue, 56.6% orthopedics, 2% ophthalmology, and 4% neurology cases. Congenital anomalies were found in 44.65% of 56 patients with soft tissue disease. Orthopedic examination revealed, 57.1% of the cases had fractures, 23.8% had arthritis and 19% had tendon diseases. It was determined that 37.3% of the surgical cases between 2017 and 2023 were soft tissue-related. In addition to soft tissue diseases, there were 5 ophthalmologic cases, including orbital mass (n=2) and dermoid cyst (n=3) Conclusion Finally, while cattle breeding has great economic importance in our country, calf losses occur due to economic conditions such as artificial insemination errors, irregular registration systems, lack of standardization of care and housing, incorrect intervention of the patient owner, and treatment costs. It is envisaged that economic losses will be minimized with early diagnosis, early intervention, appropriate medical treatment, and surgical treatment options.Öğe Relationship between growth performance, passive immunity and health In preweaned lambs(Erciyes Üniv. Veteriner Fakültesi, 2024) Gökçe, Orhan; Ayvazoğlu, Cemalettin; Cihan, Pınar; Atakişi, Onur; Kırkızıgül, Ali Haydar; Erdoğan, Hidayet MetinThis study was designed to investigate associations between transfer of passive immunity, selected illness-es (diarrhoea, pneumonia, and fatigue anorexia syndrome-FAS) and growth performance [body weight (BW) and aver-age daily gain (ADG)] in preweaned lambs. A total of 347 lambs were blood sampled at 24±1 h of age after birth and the serum IgG concentration for each lamb was measured after colostrum intake using a commercial ELISA kit. Lambs were weighed on a scale immediately after birth (before colostrum intake) and reweighed on day 28 (end of neonatal period) and day 84 (age of weaning). Lambs ADG was calculated from 0 to 28 d of life, from 29 to 84d of life, and from 0 to 84 d of life. Growth performance (BW and ADG) of lambs with diarrhoea and FAS in the neonatal period and with pneumonia in the postneonatal period was significantly lower than that of healthy lambs of the same period (P<0.05). BW of lambs with serum IgG concentration at 24th hour after the birth (SIgGC-24)<600 mg/dL and <1000 mg/ml was significantly lower on days 28 and 84 than that of lambs with SIgGC-24 >600 mg/dL and >1000 mg/ml (P<0.001). Simi-larly, the ADG of lambs with SIgGC-24 <600 mg/dL and <1000 mg/ml was significantly lower on days from 0-28, 29-84 and 0-84 of age than those of lambs with SIgGC-24 >600 mg/dL and >1000 mg/ml (P<0.001). In conclusion, our find-ings show that low serum IgG concentration in lambs, as well as the presence of pneumonia, diarrhea and FAS, reduc-es growth performance in pre-weaning lambs.Öğe Histiocytic sarcoma complex in the palpebral conjunctiva of a seven-month-old dog(Universiteit Gent, 2024) Avcı, Nihan; Gümüş, F.; Boztok Özgermen, B.; Yavuz, O.A seven-month-old, intact, female Anatolian Shepherd dog was referred for treatment of swelling and redness of the left eye. Ophthalmological examination revealed a pea-sized mass in the palpebral conjunctiva of the left lower eyelid. Ulcerative keratitis and blepharospasm were detected due to the irritation caused by the mass. Fluorescein staining was positive and the Schirmer tear test result was 13 mm/min. No other masses were detected in other parts of the patient’s body, and its general condition was good. The mass was removed surgically and was interpreted as histiocytic sarcoma. During a three-year, post-operative follow-up period, no recurrence of the mass was observed.Öğe The relationship between total thiol and pregnancy in hair goats(İlker ÇAMKERTEN, 2023) Dursun, ŞükrüIn order to increase increase fertility, hormonal application have been applied but, relationship between reproduction and stress/oxidant levels have not been investigated in hair goats. In this study, the relationship between increase fertility and TotalThiol levels were investigated in Hair Goats. 100 head female goats with a live weight of 45-50 kg at the age of 2-6 years and 20 heads of males with a live weight of 60-70 kg were used. In September, 100 females selected and marked, and blood samples were taken from all goats into anticoagulant tubes from vena jugularis 15 days before male introduction to the herd. Blood sampling was repeated from the same animals again before the start of lactation. Total Thiol values were found to be significant in October compared to May. It was determined that there was a difference (p?0.05) in the Total Thiol level in terms of sex and birth type. The Total Thiol level of twin-bearing hair goats was statistically different from the non-bearing hair goats while the total Thiol level in single-bearing hair goats was similar to those that gave birth to twins and those that did not. Goats with low Total Thiol value had a twin birth and goats with high Total Thiol value were have no birth. Total Thiol value was found to be important for multiple births (p?0.05). As a result, it was concluded that the Total Thiol level during the goat breeding season was related to birth rate and offspring yield in hair goats.Öğe Clinical success of clarithromycin, amoxicillin-clavulanic acid, enrofloxacin and doxycycline in dogs with infectious tracheobronchitis(İlker ÇAMKERTEN, 2023) Haydardedeoğlu, Ali Evren; Çolakoğlu, Ekrem Çağatay; Kaya, UfukCanine infectious tracheobronchitis (ITB) is a highly contagious disease of dogs expressed with remarkable respiratory signs. Therapy with antibiotics in canine ITB still remains questionable. The purpose of this study was to compare the clinical success of clarithromycin, amoxicillin-clavulanic acid, enrofloxacin and doxycycline in the treatment of canine ITB. Client-owned dogs with canine ITB signs (n=60) were enrolled in this prospective, controlled, and randomized blinded clinical trial. A computer-generated list randomization was employed to assign the dogs equally into the Group CLA: clarithromycin (25 mg/kg, PO), the Group AMX: amoxicillin and clavulanic acid (25 mg/kg, PO), the Group ENR: enrofloxacin (2.5 mg/kg, PO), and the Group DOX: doxycycline (5 mg/kg, PO). The administration of CLA alleviated the cough sign earlier than DOX. The recovery time of oculonasal discharge in group CLA were also earlier compared to the other groups. The tracheal sensitivity also disappeared earlier in the Groups CLA and AMX. In conclusion although there is no always statistically significance between groups, clarithromycin appears to be superior to other antibiotics suggesting that it can be the first antibiotic choice to alleviate the ITB signs in dogs.Öğe Antibiogram Results of Escherichia coli in Calf Diarrhea and Escherichia coli Bacteria in Aksaray Province in The Last Three Months(Afyon Kocatepe Üniv. Veteriner Fak., 2023) Haydardedeoglu, Ali Evren; Aydemir, Melek; Şenoğlu, Elif Selin; Aras, ZekiEscherichia coli is a gram-negative, facultative anaerobic, motile, non-spore-forming rod-shaped bacterium belonging to the Enterobacteriaceae family. Pathogenic E. coli are divided into two groups: extraintestinal and intestinal. Intestinal Escherichia coli pathotypes: enterotoxigenic E. coli (ETEC), enteropathogenic E. coli (EPEC), Vero- or Shiga-toxin-producing E. coli (VTEC or STEC), enterohemorrhagic E. coli (EHEC), enteroaggregative E. coli (EAEC), enteroinvasive E. coli (EIEC) and diffusely adherent E. coli (DAEC). Extraintestinal pathogenic E. coli: These can be listed as septicemic pathogenic E. coli, uropathogenic E. coli, avian pathogenic E. coli, breast pathogenic E. coli and those that cause uterine infections, endometrial pathogenic E. coli. Enterotoxigenic Escherichia coli (ETEC) is the most common cause of neonatal diarrhea in calves and is a bacterial disease that colonizes the small intestine, produces enterotoxin, and occurs among calves during the neonatal period. The aim of this study is to determine the E.coli isolates that cause neonatal calf diarrhea in the Aksaray region between January, February and March 2021. To be used in the study, internal organ samples (liver, heart, lung and mesenteric lymph node) of neonatal calves that died due to diarrhea were taken from 20 different cattle farms in the Aksaray region. One calf that died in each farm was included in the sampling, and a total of 20 calves were sampled. E.coli was isolated in 12 (60%) of the internal organ samples covering these three months. According to the antibiogram results of the samples, 50% of the isolates were converted to Amoxicillin and Erythromycin, 33.3% to Tetracycline, 58.3% to Trimethoprim-sulfamethoxazole, 66.6% to Streptomycin, 75% to Flofenicol, Gentamicin and Enrofloxacin, % 83.3 of them were found to be sensitive to Cefloxacin and Cefloxacinium.Öğe The effect of oxidative stress on the reproductive performance in Hair Goats(Hellenic Veterinary Medical Society, 2023) Dursun, ŞükrüSmall ruminants make better use of pastures with low grass yield and poor vegetation and therefore con-tribute significantly to the country’s economy. In order to achieve maximum yield from these animals, it is necessary to optimize nutrition and minimize stress factors. Oxidative stress affects the normal functioning of many physiological systems including fertility. This study was carried out to determine oxidative stress with regard to effect of antioxidants on fertility in hair goat in October and May. In this study, oxidative stress index (OSI), total oxidation level (TOS) and total antioxidant (TAS) levels were investigated in 20 male and 100 female hair goats during the breeding season (October) and out-of-season (May). Females between the ages of 2-6 years and male hair goats aged 2-4 years were used in the study. The correlation between TAS, TOS, and OSI and fertility was evaluated according to gender and season. TAS, TOS and OSI values in female hair goats were 1.28 µmol/L, 1.34 µmol/L; and 11.02 µmol/L in October and 7.13 µmol/L; 0.87 µmol/L and 0.53 µmol/L in May, respectively; as for male hair goats 1.32 µmol/L, 1.44 µmol/L and 4.24 µmol/L in October and 8.84 µmol/L; 0.32 µmol/L, and 0.63 µmol/L in May, respectively. Seasonal differences between genders and calving and infertile groups were found (P=0,001). As a result, while the increase in TOS level causes a decrease in offspring yield in hair goats, it has been concluded that the increase in TAS level positively affects the offspring’s productivity.Öğe Autologous platelet-rich plasma treatment in a dog with vincristine extravasation injury(NLM (Medline), 2023) Boztok Özgermen, BaşakExtravasation of vincristine sulfate (VS) is a common complication encountered during canine transmissible venereal tumor treatment and other hematopoietic neoplasms, such as lymphoma and leukemias. The leakage of the chemotherapeutic agent may result in soft tissue damage leading to ulceration and necrosis. Studies have shown that platelet-rich plasma consists of growth factors and cytokines, thus plays a crucial role in wound healing. This study aimed to evaluate the effects of autologous platelet-rich plasma and antimicrobial wound dressing for the treatment of VS extravasation-related acute full-thickness skin wounds. A male Aksaray Malakli shepherd dog (3 years old) was brought to our clinic with a wound on the left forelimb which appeared two days after intravenous injection of VS. Extravasation was suspected. A total of 3.5 mL autologous platelet-rich plasma was injected into the wound margins and an antimicrobial dressing containing chlorhexidine acetate was used weekly to close the wound. The wound healed without any complications in 6 weeks. It was concluded that autologous platelet-rich plasma treatment is a simple and cost-effective method for the treatment of VS extravasation-related acute full-thickness skin wounds.Öğe Thoracoscopic partial pericardiectomy for the treatment of pericardial effusion in dogs(Ankara Üniversitesi Veteriner Fakültesi, 2023) Şen, Yusuf; Bumin, Ali; Okan Şenel, Oytun; Boztok Özgermen, Başak; Haydardedeoğlu, Ali Evren; Başer, Medine İremThoracoscopy is a minimally invasive imaging method used in the imaging of the thoracic cavity. In comparison with thoracotomy, thoracoscopy provides better visualization of even the smallest lesions localized in the thoracic cavity. With the use of thoracoscopy, the operation stress in the patient and tissue trauma are reduced, and operating time is shortened. The aim of this study was to evaluate 20 dogs with severe pericardial effusion, which manifested as severe circulation disorder and respiratory distress. The patients determined with pericardial effusion as a result of radiographic and echocardiographic examinations were applied with partial pericardiectomy to achieve permanent health and it was decided to apply this with the minimally invasive thoracoscopic method. The paraxiphoid-transdiaphragmatic approach was applied to the first ten patients and the intercostal approach to the latter. Applicability of thoracoscopic partial pericardiectomy, advantages compared to open surgery, differences between two approach techniques, disadvantages, complications, and success rates were evaluated. It was concluded that this procedure was a successful procedure for dogs and the transdiaphragmatic approach was more useful. In conclusion, thoracoscopic partial pericardiectomy was determined to be easy to apply and more advantageous than open thoracotomy operations.Öğe Aksaray Üniversitesi Veteriner Fakültesi iç hastalıkları kliniğine getirilen hastaların retrospektif değerlendirilmesi(Afyon Kocatepe Üniversitesi, 2022) Aydemir, Melek; Haydardedeoğlu, Ali Evren; Çamkerten, İlker; Erdoğan, Hidayet MetinBu çalışmada yeni kurulan fakültemiz hastanesine getirilen hastaların demografik analizleri amaçlanmıştır. Bu amaçla 23.06.2015-30.06.2021 tarihleri arasında Aksaray Üniversitesi Veteriner Fakültesi İç Hastalıkları Kliniği’ne tanı ve tedavi amacıyla getirilen hastalar çalışmaya dahil edildi. Toplam 657 hastanın retrospektif değerlendirilmesi yapıldı. Hastaların yıl, ay ve türlere göre dağılımları ile hastalıkların yerleştiği sistemlere göre sınıflandırılması yapıldı. Söz konusu yıllar arasında en fazla karnivor, en az kanatlı hastanın getirildiği belirlenmiştir. Hasta yoğunluğunun en fazla olduğu yıl 2021 ve en az ise 2015 yılı olarak kaydedilmiştir. Hayvan sayısının kış mevsiminde, özellikle Şubat ayında en yüksek orana ulaştığı, yaz mevsiminde ise Temmuz ayında en az olduğu belirlenmiştir. Sistem hastalıkları yönünden değerlendirildiğinde, tüm türlerde en çok sindirim sistemi ikinci sırada ise solunum sisteminin etkilendiği vakalar tespit edilmiştir.Öğe Investigation of changes in spermatozoon characteristics, chromatin structure, and antioxidant/oxidant parameters after freeze-thawing of hesperidin (Vitamin P) doses added to ram semen(MDPI, 2022) Yeni, Deniz; Güngor, Şükrü; Avdatek, Fatih; Gülhan, Mehmet Fuat; Olgaç, Kemal Tuna; İnanç, Muhammed Enes; Denk, Barış; Taşdemir, UmutWe conducted this study to determine the potential cryopreservative effects of different hesperidin (vitamin P; H) doses on ram semen after freeze-thawing. Semen samples were obtained from Sonmez rams using an artificial vagina. The samples were divided into six groups: control, 10, 50, 100, 250, and 500 mu g/mL H (C, H10, H50, H100, H250, and H500, respectively). At the end of the study, sperm motility and kinetic parameters, acrosome integrity (AI), mitochondrial membrane potential (MMP), viability, lipid peroxidation levels (LPL), chromatin damage, oxidant parameters, and antioxidant parameters were assayed. None of the doses of H added to the semen extender showed any enhancing effects on progressive motility compared to C (p > 0.05). In fact, H500 had negative effects (p < 0.05). Moreover, AI was the highest at the H10 dose, while LPL values were the lowest at the same dose (p < 0.05). The doses of H10 and H50 added to the Tris extender medium showed positive effects on sperm cell chromatin damage. Consequently, we can say that H doses used in this study are not effective on semen progressive motility, but the H10 dose is effective on AI and chromatin damage by reducing LPL.
