Short- and long-term effects of zinc treatment on lacrimal gland histopathology and tear functions tests in radioiodine-administered rats

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dc.contributor.authorÖrnek, Firdevs
dc.contributor.authorAcar Ergintürk, Damla
dc.contributor.authorAcar, Uğur
dc.contributor.authorÖzdemir, Özdemir
dc.contributor.authorAtılgan, Hasan İkbal
dc.contributor.authorYumuşak, Nihat
dc.contributor.authorBoztok Özgermen, Başak
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:18:07Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:18:07Z
dc.date.issued2017
dc.departmentVeteriner Fakültesi
dc.description.abstractPurpose: To investigate the short-term (1 week) and long-term (8 weeks) protective effects of zinc administration on radioiodine (RAI)-induced lacrimal gland damage of rats. Methods: A total of 40 rats were divided into two groups: an RAI group (n=20), which was administrated a single dose of 3 mCi of 131I and 1 mL physiologic saline for 7 days by gastric gavage, and a zinc group (n=20), which received a single dose of 3 mCi of 131I and 1 mL of physiologic saline containing zinc sulfate at a concentration of 10 mg/kg concentration for 7 days by gastric gavage. All rats underwent tear function tests before and 1 week after RAI administration. About 1 week after irradiation, half of the animals in each group were sacrificed and the extraorbital lacrimal glands were removed for histopathological examination. The remaining animals of the groups underwent the same procedures at 8 weeks after irradiation. Results: In the RAI and zinc groups, the mean tear production was 3.75 +/- 1.55 and 3.65 +/- 1.53 mm at baseline, 2.10 +/- 1.07 and 3.30 +/- 1.34 mm at week 1 (p=0.004), and 3.22 +/- 1.48 and 3.50 +/- 1.78 mm at week 8, respectively; further, the mean corneal fluorescein staining scores were 4.65 +/- 2.16 and 4.80 +/- 2.21 points at baseline, 7.85 +/- 1.90 and 5.45 +/- 2.06 points at week 1 (p=0.001), and 5.44 +/- 2.13 and 4.90 +/- 2.08 at week 8, respectively. The histopathological changes in rat lacrimal glands at weeks 1 and 8 were consistent with the tear function test results. Conclusions: Zinc treatment seems to be protective against RAI-induced lacrimal gland damage of rats, particularly in the acute period.
dc.identifier.doi10.5935/0004-2749.20170010
dc.identifier.endpage40en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue1en_US
dc.identifier.pmid28380100
dc.identifier.scopusqualityQ3
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20170010
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4838
dc.identifier.volume80en_US
dc.identifier.wosWOS:000397977900010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherConsel Brasil Oftalmologia
dc.relation.ispartofArquivos Brasileiros de Oftalmologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntioxidant
dc.subjectLacrimal Apparatus
dc.subjectIodine Radioisotopes
dc.subjectZinc
dc.subjectRadiation-protective Agents
dc.subjectAnimals
dc.subjectRats
dc.titleShort- and long-term effects of zinc treatment on lacrimal gland histopathology and tear functions tests in radioiodine-administered rats
dc.typeArticle

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