Short- and long-term effects of zinc treatment on lacrimal gland histopathology and tear functions tests in radioiodine-administered rats
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Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Consel Brasil Oftalmologia
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To investigate the short-term (1 week) and long-term (8 weeks) protective effects of zinc administration on radioiodine (RAI)-induced lacrimal gland damage of rats. Methods: A total of 40 rats were divided into two groups: an RAI group (n=20), which was administrated a single dose of 3 mCi of 131I and 1 mL physiologic saline for 7 days by gastric gavage, and a zinc group (n=20), which received a single dose of 3 mCi of 131I and 1 mL of physiologic saline containing zinc sulfate at a concentration of 10 mg/kg concentration for 7 days by gastric gavage. All rats underwent tear function tests before and 1 week after RAI administration. About 1 week after irradiation, half of the animals in each group were sacrificed and the extraorbital lacrimal glands were removed for histopathological examination. The remaining animals of the groups underwent the same procedures at 8 weeks after irradiation. Results: In the RAI and zinc groups, the mean tear production was 3.75 +/- 1.55 and 3.65 +/- 1.53 mm at baseline, 2.10 +/- 1.07 and 3.30 +/- 1.34 mm at week 1 (p=0.004), and 3.22 +/- 1.48 and 3.50 +/- 1.78 mm at week 8, respectively; further, the mean corneal fluorescein staining scores were 4.65 +/- 2.16 and 4.80 +/- 2.21 points at baseline, 7.85 +/- 1.90 and 5.45 +/- 2.06 points at week 1 (p=0.001), and 5.44 +/- 2.13 and 4.90 +/- 2.08 at week 8, respectively. The histopathological changes in rat lacrimal glands at weeks 1 and 8 were consistent with the tear function test results. Conclusions: Zinc treatment seems to be protective against RAI-induced lacrimal gland damage of rats, particularly in the acute period.
Açıklama
Anahtar Kelimeler
Antioxidant, Lacrimal Apparatus, Iodine Radioisotopes, Zinc, Radiation-protective Agents, Animals, Rats
Kaynak
Arquivos Brasileiros de Oftalmologia
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
80
Sayı
1
