DNA damaging effect of paclitaxel in the epididymal sperms as a chemotherapeutic agent and possible remedies to prevent this effect: A study on reproductive potential of male cancer patients of reproductive age

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dc.authorid0000-0003-0566-0684
dc.authorid0000-0002-6141-0690
dc.authorid0000-0003-3460-522X
dc.contributor.authorİli, Pınar
dc.contributor.authorSarı, Fikret
dc.contributor.authorBucak, Mustafa Numan
dc.contributor.authorÖztürk, Caner
dc.contributor.authorGüngör, Şükrü
dc.contributor.authorAtaman, Mehmet Bozkurt
dc.date.accessioned2019-07-09T07:42:01Z
dc.date.available2019-07-09T07:42:01Z
dc.date.issued2019
dc.departmentVeteriner Fakültesi
dc.descriptionÖztürk, Caner ( Aksaray, Yazar )
dc.description.abstractCancer is a major public health problem, young cancer patients therefore undergo chemotherapy, andmost of them may lose their fertility. DNA damage level provides important clues about the quality andreproductive potential of spermatozoa. In this study, we evaluated the levels of both DNA fragmentationand abnormal DNA integrity in the epididymal sperms of New Zealand rabbit (Oryctolagus cuniculus)after cryopreservation using the terminal deoxyribonucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) assay and the toluidine blue (TB) staining methods and assessed the effects of pacli-taxel, resveratrol,L-glutamine (LG), and basal medium eagle (BME) solution on DNA damage. Paclitaxelinduced the levels of both DNA damages in the sperms, but resveratrol ameliorated this effect. LG andBME supplementation to the extender prevented the sperm samples from DNA fragmentation aftercryopreservation. Chemotherapy drugs containing paclitaxel can cause the sperm DNA to be damaged,and hence adversely affect the fertility of male cancer patients of reproductive age. The administration ofresveratrol together with paclitaxel may ameliorate the DNA damage inducing effect of paclitaxel. Spermbanking and cryopreservation with the appropriate cryoprotectants such as LG and BME prior to cancertreatment can also be suggested to all male cancer patients of reproductive age facing cancer treatmentfor fertility preservation.
dc.description.abstract...
dc.identifier.doi10.1016/j.theriogenology.2019.04.015
dc.identifier.endpage211en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage201en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.theriogenology.2019.04.015
dc.identifier.urihttps://hdl.handle.net/20.500.12451/2009
dc.identifier.volume132en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ltd.
dc.relation.ispartofTheriogenology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPaclitaxel
dc.subjectResveratrol
dc.subjectDNA Damage
dc.subjectCryopreservation
dc.subjectCancer
dc.subjectFertility
dc.titleDNA damaging effect of paclitaxel in the epididymal sperms as a chemotherapeutic agent and possible remedies to prevent this effect: A study on reproductive potential of male cancer patients of reproductive age
dc.typeArticle

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