Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair

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dc.authoridBayram, Cem -- 0000-0001-8717-4668; SAGLAM, NECDET -- 0000-0002-5463-8355
dc.contributor.authorKarahaliloğlu, Zeynep
dc.contributor.authorDemirbilek, Murat
dc.contributor.authorŞam, Mesut
dc.contributor.authorSağlam, Necdet
dc.contributor.authorMızrak, Alpay Koray
dc.contributor.authorDenkbaş, Emir Baki
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:30:17Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:30:17Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThe aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun bacterial PHB was modified with PEG- or EDA via radio frequency glow discharge method. After plasma modification, contact angle of EDA-modified PHB scaffolds decreased from 110 +/- 1.50 to 23 +/- 0.5 degree. Interestingly, less calcium oxalate stone deposition was observed on modified PHB scaffolds compared to that of non-modified group. Results of this study show that surface-modified scaffolds not only inhibited calcium oxalate growth but also enhanced the uroepithelial cell viability and proliferation.
dc.description.sponsorshipHacettepe University, Scientific Researches Unit
dc.description.sponsorshipThis study was carried out under the auspices of the Hacettepe University, Scientific Researches Unit.
dc.identifier.doi10.3109/21691401.2014.913053
dc.identifier.endpage82en_US
dc.identifier.issn2169-1401
dc.identifier.issn2169-141X
dc.identifier.issue1en_US
dc.identifier.pmid24863802
dc.identifier.scopusqualityQ1
dc.identifier.startpage74en_US
dc.identifier.urihttps://doi.org/10.3109/21691401.2014.913053
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6259
dc.identifier.volume44en_US
dc.identifier.wosWOS:000368022400010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.ispartofArtificial Cells, Nanomedicine and Biotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBladder Reconstruction
dc.subjectCalcium Oxalate Stones
dc.subjectNanotexture
dc.subjectpoly [(R)-3-hydroxybutyrate] (PHB)
dc.subjectTissue Engineering
dc.titleSurface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair
dc.typeArticle

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