Surface-modified bacterial nanofibrillar PHB scaffolds for bladder tissue repair
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of the study is in vitro investigation of the feasibility of surface-modified bacterial nanofibrous poly [(R)-3-hydroxybutyrate] (PHB) graft for bladder reconstruction. In this study, the surface of electrospun bacterial PHB was modified with PEG- or EDA via radio frequency glow discharge method. After plasma modification, contact angle of EDA-modified PHB scaffolds decreased from 110 +/- 1.50 to 23 +/- 0.5 degree. Interestingly, less calcium oxalate stone deposition was observed on modified PHB scaffolds compared to that of non-modified group. Results of this study show that surface-modified scaffolds not only inhibited calcium oxalate growth but also enhanced the uroepithelial cell viability and proliferation.
Açıklama
Anahtar Kelimeler
Bladder Reconstruction, Calcium Oxalate Stones, Nanotexture, poly [(R)-3-hydroxybutyrate] (PHB), Tissue Engineering
Kaynak
Artificial Cells, Nanomedicine and Biotechnology
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
44
Sayı
1
