Controlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula

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dc.authoridSargin, Idris -- 0000-0003-3785-9575; Tan, Gamze -- 0000-0002-2755-1756; Kaya, Murat -- 0000-0001-6954-2703
dc.contributor.authorSargın, İdris
dc.contributor.authorAkyüz, Lalehan
dc.contributor.authorKaya, Murat
dc.contributor.authorTan, Gamze
dc.contributor.authorÇeter, Talip
dc.contributor.authorYıldırım, Keyser
dc.contributor.authorErtosun, Şeymanur
dc.contributor.authorAydın, Gözde Hatun
dc.contributor.authorTopal, Müge
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:43Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:43Z
dc.date.issued2017
dc.departmentSabire Yazıcı Fen-Edebiyat Fakültesi
dc.description.abstractSporopollenin is a promising material for drug encapsulation due to its excellent properties; uniformity in size, non-toxicity, chemically and thermally resilient nature. Herein, morphologically intact sporopollenin microcapsules were extracted from Betula pendula pollens. Cancer therapeutic agent (imatinib mesylate) was loaded into the microcapsules. The encapsulation efficiency by passive loading technique was found to be 21.46%. Release behaviour of the drug from microcapsules was found to be biphasic, with an initial fast release followed by a slower rate of release. Imatinib mesylate release from the drug itself (control) was faster than from imatinib mesylate-loaded sporopollenin microcapsules. The release profiles for both free and entrapped drug samples were significantly slower and more controlled in PBS buffer (pH 7.4) than in HCl (pH 1.2) buffer. Cumulative drug release from IM-MES-loaded sporopollenin microcapsules was found to be 65% within 24 h for PBS, whereas release from the control was completed within 1 h. Also, a complete dissolution of control in HCl buffer was observed within first 30 min. MTT assay revealed that drug-loaded microcapsules were effective on WiDr human colon carcinoma cell line. B. pendula sporopollenin can be suggested as an effective carrier for oral delivery of imatinib mesylate.
dc.identifier.doi10.1016/j.ijbiomac.2017.07.093
dc.identifier.endpage756en_US
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid28716746
dc.identifier.scopusqualityQ1
dc.identifier.startpage749en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2017.07.093
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6076
dc.identifier.volume105en_US
dc.identifier.wosWOS:000414882900084
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPollen
dc.subjectEncapsulation
dc.subjectOral Drug Delivery
dc.subjectMicrocapsule
dc.titleControlled release and anti-proliferative effect of imatinib mesylate loaded sporopollenin microcapsules extracted from pollens of Betula pendula
dc.typeArticle

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