Impact of endothelial NOS VNTR variant on susceptibility to diabetic neuropathy and type 2 diabetes mellitus

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dc.contributor.authorYiğit, Serbülent
dc.contributor.authorNursal, Ayşe Feyda
dc.contributor.authorUzun, Süheyla
dc.contributor.authorRüstemoğlu, Hüsniye
dc.contributor.authorDashatan, Payam Amiri
dc.contributor.authorSoylu, Hüseyin
dc.contributor.authorAtmaca, Ayşegül
dc.contributor.authorRüstemoğlu, Aydın
dc.contributor.authorKuruca, Nilüfer
dc.contributor.authorKarakuş, Nevin
dc.date.accessioned2021-06-24T10:58:55Z
dc.date.available2021-06-24T10:58:55Z
dc.date.issued2021
dc.departmentTıp Fakültesi
dc.description*Rüstemoğlu, Aydın ( Aksaray, Yazar )
dc.description.abstractPurpose: The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN. Methods: A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was geno-typed by polymerase chain reaction (PCR) method. Results: eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p= 0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively). Conclusion: The eNOS VNTR “4b/4b” homozygous genotype and hence “4b”allele as a genetic risk factor for T2DM and DPN, which may serve as a useful marker of increased susceptibility to the risk of these disorders.
dc.identifier.doi10.2174/1567202617999201214230147
dc.identifier.endpage705en_US
dc.identifier.issn1567-2026
dc.identifier.issue5en_US
dc.identifier.pmid33319671
dc.identifier.scopusqualityQ3
dc.identifier.startpage700en_US
dc.identifier.urihttps:/dx.doi.org/10.2174/1567202617999201214230147
dc.identifier.urihttps://hdl.handle.net/20.500.12451/8170
dc.identifier.volume17en_US
dc.identifier.wosWOS:000621397600011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBentham Science
dc.relation.ispartofCurrent Neurovascular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes Mellitus
dc.subjectDiabetic Peripheral Neuropathy
dc.subjectEndothelial NOS VNTR Variant
dc.subjectGenotype
dc.subjectHyperglycemia
dc.subjectPeripheral Nerve
dc.titleImpact of endothelial NOS VNTR variant on susceptibility to diabetic neuropathy and type 2 diabetes mellitus
dc.typeArticle

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