Impact of endothelial NOS VNTR variant on susceptibility to diabetic neuropathy and type 2 diabetes mellitus
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bentham Science
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: The aim of this study was to evaluate whether the VNTR intron 4b/4a variant in the eNOS gene is associated with type 2 diabetes mellitus (T2DM) and DPN. Methods: A total of 598 subjects were enrolled in the study. eNOS VNTR 4b/4a variant was geno-typed by polymerase chain reaction (PCR) method. Results: eNOS VNTR intron 4b/4b genotype and b allele increased in patients with both DPN and T2DM compared healthy controls (p=0.0005, OR:1.94, p= 0.000002, OR:4.10, respectively). 4a/4b genotype was more prevalent in controls than in DPN and T2DM patients (p=0.00008, OR:0.46; p=0.000004, OR:0.24, respectively). eNOS VNTR b allele was more common in DPN patients and T2DM patients compared with controls (p=0.007, p=0.00002, respectively). Conclusion: The eNOS VNTR “4b/4b” homozygous genotype and hence “4b”allele as a genetic risk factor for T2DM and DPN, which may serve as a useful marker of increased susceptibility to the risk of these disorders.
Açıklama
*Rüstemoğlu, Aydın ( Aksaray, Yazar )
Anahtar Kelimeler
Diabetes Mellitus, Diabetic Peripheral Neuropathy, Endothelial NOS VNTR Variant, Genotype, Hyperglycemia, Peripheral Nerve
Kaynak
Current Neurovascular Research
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
17
Sayı
5
