The Protective Effects of Chrysin on Acrylamide-Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats

Basit Öğe Kaydı
dc.authorid0000-0003-3936-4146
dc.authorid0000-0002-8457-9448
dc.authorid0000-0001-5573-4923
dc.authorid0000-0001-6775-7858
dc.authorid0000-0002-8222-5515
dc.authorid0000-0002-8490-2479
dc.contributor.authorGencer, Selman
dc.contributor.authorAkaras, Nurhan
dc.contributor.authorŞimşek, Hasan
dc.contributor.authorGür, Cihan
dc.contributor.authorİleritürk, Mustafa
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2025-07-09T12:04:24Z
dc.date.available2025-07-09T12:04:24Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractAcrylamide (ACR) is a toxic chemical with a high carcinogenic risk that is released as a result of heating or processing foods at high temperatures. Chrysin (CHR) is a flavonoid that is naturally found in foods such as honey and passionflower and stands out with its antioxidant, anticancer, and anti-inflammatory properties. This study aims to determine the protective effects of CHR in ACR-induced hepatotoxicity. ACR was administered orally at a dose of 38.27 mg/kg; CHR (25 or 50 mg/kg) was administered orally for ten days. Biochemical and molecular methods were used to investigate oxidative stress, inflammation, and apoptotic markers in liver tissue. Additionally, histological methods were used to determine the liver tissue's structural and functional characteristics and autophagy. CHR treatment alleviated ACR-induced oxidative stress by increasing antioxidants (SOD, CAT, GPx, GSH) and reducing increased oxidant MDA. CHR reduced inflammatory activity by inactivating NF-κB and pro-inflammatory cytokines. ACR-induced increases in apoptotic Casp-3, Casp-6, Casp-9, and Bax were reduced by CHR, while the decreased level of antiapoptotic Bcl-2 was increased. It was also determined immunohistochemically that CHR inhibited autophagic Beclin-1 activity. CHR was effective in reducing ACR-induced hepatotoxicity damage and may be an effective treatment option.
dc.identifier.doi10.1002/jbt.70334
dc.identifier.issn10956670
dc.identifier.issue6
dc.identifier.pmid40488268
dc.identifier.scopus105008349852
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.70334
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13228
dc.identifier.volume39
dc.identifier.wosWOS:001503958000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.institutionauthorGencer, Selman
dc.institutionauthorAkaras, Nurhan
dc.institutionauthorŞimşek, Hasan
dc.institutionauthorKandemir, Fatih Mehmet
dc.institutionauthorid0000-0003-3936-4146
dc.institutionauthorid0000-0002-8457-9448
dc.institutionauthorid0000-0001-5573-4923
dc.institutionauthorid0000-0002-8490-2479
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcrylamide
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectChrysin
dc.subjectHepatotoxicity
dc.subjectİnflammation
dc.titleThe Protective Effects of Chrysin on Acrylamide-Induced Hepatotoxicity: Insights Into Oxidative Stress, Inflammation, Apoptosis, Autophagy, and Histological Evaluation in Rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
gencer-selman-2025.pdf
Boyut:
1.98 MB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Makale Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu