Evaluation of neuroprotective effect of sevoflurane in acute traumatic brain injury: An experimental study in rats

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dc.authorid0000-0001-7351-8968
dc.authorid0000-0002-3339-4195
dc.contributor.authorDoğan, Güvenç
dc.contributor.authorKaraca, Onur
dc.date.accessioned2020-04-09T07:40:28Z
dc.date.available2020-04-09T07:40:28Z
dc.date.issued2020
dc.departmentTıp Fakültesi
dc.descriptionKaraca, Onur ( Aksaray, Yazar )
dc.description.abstractAIM: To examine the effect of sevoflurane, a halogenated anesthetic used in clinical applications, on oxidative stress and inflammation after an acute traumatic brain injury (TBI) in rats. MATERIAL and METHODS: Thirty male Sprague-Dawley rats were divided into three groups: control (Group 1), trauma (Group 2), and trauma+sevoflurane (Group 3). A diffuse TBI model was created for Groups 2 and 3. Sevoflurane anesthesia was applied 6 hours a day after induced trauma in Group 3. Glutathione (GSH), malondialdehyde (MDA), and tissue myeloperoxidase (MPO) activities were measured in the blood. Tumor necrosis factor alpha (TNF-alpha), vascular endothelial growth factor (VEGF), and Bax primary antibodies were used to determine the effects of TBI. RESULTS: MDA was significantly higher in Group 2 than in Group 1. There was a significant increase in tissue MPO levels in Groups 2 and 3 compared with those in Group 1. GSH levels decreased in Groups 2 and 3. Group 3 revealed degenerative changes in neurons and glial cells, vascular enlargement and congestion, and inflammatory cell infiltration around blood vessels. In Group 3, VEGF expression was positive in endothelial and inflammatory cells around blood vessels. Group 3 had positive TNF-alpha expression in neurons, small granular cells, and glial cells around blood vessels.
dc.identifier.doi10.5137/1019-5149.JTN.27680-19.2
dc.identifier.endpage243en_US
dc.identifier.issn1019-5149
dc.identifier.issue2en_US
dc.identifier.pmid32091120
dc.identifier.scopusqualityQ3
dc.identifier.startpage237en_US
dc.identifier.urihttps:/dx.doi.org/10.5137/1019-5149.JTN.27680-19.2
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7511
dc.identifier.volume30en_US
dc.identifier.wosWOS:000519545800013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish Neurosurgical Society / Türk Nöroşirürji Derneği
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTraumatic Brain Injury
dc.subjectSevoflurane
dc.subjectVEGF
dc.subjectBAX Antibodies
dc.subjectRat
dc.titleEvaluation of neuroprotective effect of sevoflurane in acute traumatic brain injury: An experimental study in rats
dc.typeArticle

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