Evaluation of neuroprotective effect of sevoflurane in acute traumatic brain injury: An experimental study in rats
Yükleniyor...
Dosyalar
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurosurgical Society / Türk Nöroşirürji Derneği
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
AIM: To examine the effect of sevoflurane, a halogenated anesthetic used in clinical applications, on oxidative stress and inflammation after an acute traumatic brain injury (TBI) in rats. MATERIAL and METHODS: Thirty male Sprague-Dawley rats were divided into three groups: control (Group 1), trauma (Group 2), and trauma+sevoflurane (Group 3). A diffuse TBI model was created for Groups 2 and 3. Sevoflurane anesthesia was applied 6 hours a day after induced trauma in Group 3. Glutathione (GSH), malondialdehyde (MDA), and tissue myeloperoxidase (MPO) activities were measured in the blood. Tumor necrosis factor alpha (TNF-alpha), vascular endothelial growth factor (VEGF), and Bax primary antibodies were used to determine the effects of TBI. RESULTS: MDA was significantly higher in Group 2 than in Group 1. There was a significant increase in tissue MPO levels in Groups 2 and 3 compared with those in Group 1. GSH levels decreased in Groups 2 and 3. Group 3 revealed degenerative changes in neurons and glial cells, vascular enlargement and congestion, and inflammatory cell infiltration around blood vessels. In Group 3, VEGF expression was positive in endothelial and inflammatory cells around blood vessels. Group 3 had positive TNF-alpha expression in neurons, small granular cells, and glial cells around blood vessels.
Açıklama
Karaca, Onur ( Aksaray, Yazar )
Anahtar Kelimeler
Traumatic Brain Injury, Sevoflurane, VEGF, BAX Antibodies, Rat
Kaynak
Turkish Neurosurgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
30
Sayı
2
