Assessing Algerian Ilex aquifolium L.’s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer’s, diabetes and skin diseases
| dc.authorid | 0000-0003-0274-7362 | |
| dc.authorid | 0000-0001-8154-156X | |
| dc.authorid | 0000-0001-8954-5485 | |
| dc.contributor.author | Hadroug, Aldjia | |
| dc.contributor.author | Zengin, Gökhan | |
| dc.contributor.author | Belhattab, Rachid | |
| dc.contributor.author | Çakmak, Yavuz Selim | |
| dc.date.accessioned | 2024-11-19T08:39:28Z | |
| dc.date.available | 2024-11-19T08:39:28Z | |
| dc.date.issued | 2024 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description.abstract | This research explored the impact of methanolic extracts from the fruits and leaves of Ilex aquifolium L., a rare Algerian species, on several enzymes, focusing on tyrosinase, ?-amylase, ?-glucosidase, and cholinesterases, as well as their antioxidant potential in vitro assays, including phosphomolybdenum, DPPH, ABTS, CUPRAC, FRAP, and MCA. HPLC-DAD analysis identified chlorogenic acid, rosmarinic acid, hesperidin, and quercetin as predominant phenolic components. Both extracts exhibited notable antioxidant properties, up to 250.08?mg TE/g for fruits and 237.08?mg TE/g for leaf extracts. Enzyme inhibitory assays demonstrated significant inhibition against AChE and BChE with maximum activities of 2.34?mg GALAE/g in leaves and 4.32?mg GALAE/g in fruits. Additionally, considerable tyrosinase inhibition was observed in leaves at 39.69?mg KAE/g. These findings highlight I. aquifolium L. as a valuable source for investigating natural antioxidants and enzyme inhibitors, particularly for possible cosmetics and food additives applications. | |
| dc.identifier.doi | 10.1080/14786419.2024.2419498 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.uri | https:/dx.doi.org/10.1080/14786419.2024.2419498 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/12653 | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Taylor & Francis | |
| dc.relation.ispartof | Natural Product Research | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | Ilex Aquifolium L | |
| dc.subject | Bioactive Compounds | |
| dc.subject | Antioxidant Activity | |
| dc.subject | Enzyme Inhibition Effect | |
| dc.title | Assessing Algerian Ilex aquifolium L.’s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer’s, diabetes and skin diseases | |
| dc.type | Article |
