Assessing Algerian Ilex aquifolium L.’s phenolic compounds, antioxidant and enzyme inhibitory properties to find a new natural remedy for Alzheimer’s, diabetes and skin diseases

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Tarih

2024

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Yayıncı

Taylor & Francis

Erişim Hakkı

info:eu-repo/semantics/embargoedAccess

Özet

This research explored the impact of methanolic extracts from the fruits and leaves of Ilex aquifolium L., a rare Algerian species, on several enzymes, focusing on tyrosinase, ?-amylase, ?-glucosidase, and cholinesterases, as well as their antioxidant potential in vitro assays, including phosphomolybdenum, DPPH, ABTS, CUPRAC, FRAP, and MCA. HPLC-DAD analysis identified chlorogenic acid, rosmarinic acid, hesperidin, and quercetin as predominant phenolic components. Both extracts exhibited notable antioxidant properties, up to 250.08?mg TE/g for fruits and 237.08?mg TE/g for leaf extracts. Enzyme inhibitory assays demonstrated significant inhibition against AChE and BChE with maximum activities of 2.34?mg GALAE/g in leaves and 4.32?mg GALAE/g in fruits. Additionally, considerable tyrosinase inhibition was observed in leaves at 39.69?mg KAE/g. These findings highlight I. aquifolium L. as a valuable source for investigating natural antioxidants and enzyme inhibitors, particularly for possible cosmetics and food additives applications.

Açıklama

Anahtar Kelimeler

Ilex Aquifolium L, Bioactive Compounds, Antioxidant Activity, Enzyme Inhibition Effect

Kaynak

Natural Product Research

WoS Q Değeri

Scopus Q Değeri

Q1

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