Protective effects of safranal on kidney tissue in a rat model of distant ischemia- reperfusion injury with infrarenal aortic occlusion

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dc.authorid0000-0001-8414-3751
dc.authorid0000-0002-3536-3253
dc.authorid0000-0003-3902-9831
dc.authorid0000-0002-9086-515X
dc.authorid0000-0003-0918-5032
dc.authorid0000-0002-7659-6635
dc.authorid0000-0002-4795-2266
dc.authorid0000-0003-0995-3986
dc.authorid0000-0001-5223-4763
dc.authorid0000-0001-9929-0930
dc.contributor.authorTort, Mehmet
dc.contributor.authorSevil, Hülya
dc.contributor.authorSevil, Fehim Can
dc.contributor.authorBecit, Necip
dc.contributor.authorAksu, Uğur
dc.contributor.authorSarıtaş, Zülfükar
dc.contributor.authorDemirel, Hasan Hüseyin
dc.contributor.authorBülbül, Aziz
dc.contributor.authorYaşar, Zehra
dc.contributor.authorBecit Kızılkaya, Merve
dc.contributor.authorSarıtaş, Hazen
dc.date.accessioned2024-03-27T12:04:56Z
dc.date.available2024-03-27T12:04:56Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractIschemia-reperfusion (IR) injury to a part of the body can cause damage to distant organs such as the kidney and heart. This study investigated the protective effects of safranal against IR-induced renal injury. Materials and methods: Used in this study were 24 Wistar Albino male rats, which were divided into 3 equal and randomised groups. The sham group underwent laparotomy only. In the IR group, the infrarenal aorta was clamped for 1 h, and then reperfused for 2 h. In the IR-safranal group, safranal was administered 30 min before the procedure and IR injury was induced in the same way as in the IR group. After the procedure, blood and tissue samples were collected from the rats for biochemical and histopathological analyses. Antioxidant capacity and proinflammatory cytokine analyses were performed on the blood samples. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining was performed to determine the number of cells undergoing apoptosis in the kidney tissue. Results: The estimated glomerular filtration rate, an indicator of renal function, was lower in the IR group (p1 = 0.024 vs. p3 = 0.041, respectively) compared to the other groups, while creatinine levels were higher in the IR group compared to the other groups (p1 = 0.032 vs. p2 = 0.044, respectively). The blood urea nitrogen level was higher in the IR group than in the other groups (p1 = 0.001vs p2 = 0.035, respectively). The total antioxidant and total oxidant status, indicating tissue oxidative stress, did not differ between groups (p = 0.914 vs. p = 0.184, respectively). Among the proinflammatory cytokines, the interleukin-1? (IL-1?) and IL-6 levels were significantly higher in the IR group (p = 0.034 vs. p = 0.001, respectively), but the tumour necrosis factor-? (p = 0.19), and interferon-? (p = 0.311) levels did not differ between groups. Histopathological examination showed significantly less damage to glomerular and tubular cells in the IR- safranal group (p < 0.001). The number of TUNEL-positive cells was higher in the IR group compared to the other groups (p < 0.001). Conclusion: Safranal may have protective effects against kidney damage caused by distant ischemia-reperfusion injury.
dc.identifier.doi10.55730/1300-0144.5726
dc.identifier.endpage1581en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue6en_US
dc.identifier.pmid38813504
dc.identifier.scopusqualityQ1
dc.identifier.startpage1574en_US
dc.identifier.urihttps:/dx.doi.org10.55730/1300-0144.5726
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11571
dc.identifier.volume53en_US
dc.identifier.wosWOS:001127245500037
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTÜBİTAK
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectInfrarenal Aortic Occlusion
dc.subjectischemia and Reperfusion
dc.subjectRenal Injury
dc.subjectSafranal
dc.titleProtective effects of safranal on kidney tissue in a rat model of distant ischemia- reperfusion injury with infrarenal aortic occlusion
dc.typeArticle

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