Makale Koleksiyonu

Bu koleksiyon için kalıcı URI

https://hdl.handle.net/20.500.12451/347

Listeleniyor 1 - 20 / 376

Thiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera
(Kare Yayıncılık, 2023) Erdal, Hüseyin; Çiftçiler, Rafiye; Tuncer, Sibel Çiğdem; Özcan, Oğuzhan
The present study aims to indicate both thiol-disulfide hemostasis and ischemia-modified albumin (IMA) levels in patients with Polycythemia Vera (PV). Methods: In this prospective case-control study, 34 PV patients and 31 healthy control participants were included. Thi- ol levels were measured with a new modified colorimetric method. IMA levels were determined by cobalt binding test. Results: Thiol levels were statistically significant between the groups. (p<0.001). IMA levels were also significanlty high- er in PV group than healthy control subjects (p<0.001). We revealed that thiol and IMA levels were significantly higher in patients with PV in respect to the control groups. Conclusion: The obtain results indicate that the oxidative balance is disturbed and changed towards the oxidant direc- tion. The dynamic- thiol disulfide balance has moved to proliferation side in patients with PV, and may provide impor- tant contributions to the patient's follow-up and disease pathophysiology.
The Examination of Galectin-3 Levels in Children with Attention Deficit and Hyperactivity Disorder
(Kare Yayıncılık, 2023) Artık, Abdulbaki; Kocaman, Orhan; Kara, Halil
The etiopathogenesis of ADHD involves genetic, environmental, psychological, and brain structural vari- ables. Inflammation is one ADHD etiology study field. Galectin-3 may enhance inflammation by inhibiting the anti- inflammatory cytokine interleukin-10 (IL-10). This study examined the link between blood galectin-3 concentrations and ADHD severity and levels in children with ADHD. Methods: The clinic treated 34 first-time ADHD patients aged 5.2-14.1. Non-psychotropic first-time diagnoses were chosen. Patients were compared to 21 age- and gender-matched healthy controls. After a paediatrician exam, a psychi- atrist screens healthy controls for mental illness using the Schedule for Mood Disorders and Schizophrenia in School- Age Children, Now and Lifetime Version-DSM-5 (K-SADS-PL-DSM-5). Conners' Parent Rating Scale (CPRS) and Conners' Teacher Rating Scale( CTRS) were used for diagnosis by a child and adolescent psychiatrist. Results: Mean serum galectin-3 levels were compared between ADHD group and control groups. Serum galectin-3 level was 428.6 (SD±194.4) in the ADHD group and 183.7 ng/ml (SD±49.6) in the control group. ADHD group is found to have statistically significantly higher galectin-3 concentrations when compared to the control group (z=-5.15, p<.001). Conclusion: In our study, it was found that serum galectin-3 levels were higher in children with ADHD and there was a significant correlation between ADHD severity and serum galectin-3 levels. Based on these findings, it is thought that galectin-3 may be associated with the etiopathogenesis of ADHD.
Analysis of some measurement parameters that may predict the risk of developing obesity: a clinical study
(2023) Bulut Çelik, Sercan; Erten Bucaktepe, Pakize Gamze; Bulut Batur, Ülkü; Umud Bulut, İbrahim
Obesity is a severe and chronic disease, which is currently increasing rapidly. The aim of this study was to reveal some parameters that can predict the risk of obesity and to create a new scale using these parameters.Material and Method: The demographic information of the study subjects was recorded, together with the anthropometric measurements of Body Mass Index (BMI), blood pressure, height, body weight, waist circumference, and hip circumference were recorded.Results: Evaluation was made of 74 subjects, comprising 11 (14.9%) females and 63 (85.1%) males with a median age of 34 years (24-45). Mean body weight was measured as 77.3±12.46 kg, height as 174.3±8.86 cm, waist circumference as 84 (66-103) cm, hip circumference as 97 (83-121) cm, and BMI as 25.4±3.21 kg/m2. It was seen that the risk of developing obesity could increase when age and duration of work increased, with an increased frequency of eating outside the home, in the absence of regular exercise, and when the waist and hip circumference values increased. Regression analysis showed that body weight, waist, and hip circumference measurement values could be used to predict the obesity development risk. Finally, a valid and reliable scale called OBEZRISK was created that would easily predict the risk of obesity development in individuals.Conclusion: The study results showed that body weight, waist, and hip circumference measurement values could be used to predict the risk of obesity development in individuals. It was also concluded that the OBEZRISK scale could be used to predict the risk of developing obesity.
Can the Pan-Immune Inflammation Value, Systemic Inflammatory Response Index, and Other Hematological Inflammatory Indices Be Clinically Used to Predict Pseudoexfoliation
(Ali Cangül, 2024) Erdal, Hüseyin; Kılıç, Abdullah Onur; Akbulut Yağcı, Betul; Yaşar, Erdoğan
Pseudoexfoliation (PEX) syndrome is a systemic condition associated with age, and its exact cause remains elusive. Inflammatory processes heighten the risk of PEX development. This study marks the first attempt to jointly investigate the Systemic Inflammatory Response Index (SIRI) and Pan-Immune Inflammation Value (PIV) biomarkers in PEX patients. Materials and Methods: A total of 84 patients and 71 healthy controls underwent examination. Ratios of neutrophils to lymphocytes (NLR) and platelets to lymphocytes (PLR), along with the Systemic Inflammation Index (SII), SIRI, and PIV values, were computed as indicators linked to the inflammatory cascade. Results: The study encompassed 155 subjects, including 71 healthy controls averaging 73.8±7.7 years and 84 PEX patients averaging 71.3±8.9 years. Statistically significant differences in neutrophil and lymphocyte levels were evident between the groups (p<0.05). A notable statistical distinction was observed in the NLR, PLR, derived Neutrophil to Lymphocyte Ratio (dNLR), SII, SIRI, and PIV indices when comparing the groups (p<0.05). However, hemoglobin, platelet, mean platelet volume (MPV), white blood cell (WBC), and C-reactive protein (CRP) values did not show significant differences between the groups (p>0.05). Conclusion: This study highlights that SIRI and PIV could provide insights into the relationship between PEX and inflammation, offering a glimpse into the potential systemic implications of PEX-related inflammation.
Assessment of the Diagnostic and Prognostic Value of the Serum Netrin-1 Level in Patients Presenting the Emergency Department with Sepsis
(Kafkas Üniversitesi Tıp Fakültesi, 2024) Gönen, Mustafa Önder; Cander, Başar; Köylü, Ramazan; Mutlu, Hüseyin; Yazıcı, Ramiz; Köylü, Öznur
Sepsis affects approximately 50 million people across the world each year and causes 11 million deaths. Many biomarkers have been investigated for the early diagnosis of sepsis and patient responses to infection and treatment, as well as to help clinicians predict risk and plan treatment. Netrin-1 plays an important role by directing the migration of neutrophils, particularly monocytes, in inflamed tissue. This study aimed to determine whether Netrin-1 was an effective marker in the diagnosis, treatment follow-up, and prognosis evaluation of patients with sepsis and septic shock. Material and Method: This observational and prospective study was conducted at the emergency department with 121 individu - als over 18, including 71 patients diagnosed with sepsis and 50 healthy volunteers. The patients were further evaluated in two sub- groups: sepsis and septic shock. Blood samples were taken from the patient and control groups at the time of presentation and on the third day. Netrin-1 levels were examined in both groups. Results: The netrin-1 levels of the patients with sepsis and septic shock upon presentation to the hospital were significantly higher than the control group (p<0.0001). However, there was no signifi - cant difference between the netrin-1 levels measured at the time of presentation and on the third day in the sepsis and septic shock groups (p: 0.0522 and 0.0786, respectively). Neither the presenta- tion nor the third-day netrin-1 level had a statistically significant correlation with mortality (p=0.075 and 0.254, respectively). Conclusion: Our results showed that netrin-1 was an effective biomarker for diagnosing sepsis and septic shock. However, it was not a risk factor for mortality or clinical risk scores in patients with these conditions.
Oxidative stress in viral hepatitis
(Effect Publishing Agency ( EPA ), 2024) Erdal, Hüseyin; Kalaycı, Hacer Özlem
Viral hepatitis, primarily caused by hepatitis B virus (HBV) and hepatitis C virus (HCV), is a leading cause of chronic liver disease worldwide. Accumulating evidence suggests that oxidative stress (OS) plays a pivotal role in the pathogenesis and progression of viral hepatitis. OS occurs due to a disproportion between reactive oxygen species (ROS) generation and antioxidant protection, resulting in damage to cells and tissues. In viral hepatitis, viral proteins and immune-mediated inflammatory responses contribute to excessive ROS generation, resulting in oxidative damage to hepatocytes. This damage manifests as lipid peroxidation, DNA damage, and protein oxidation, which in turn promote hepatic inflammation, fibrosis, and hepatocellular carcinoma. Furthermore, OS has been implicated in the resistance to antiviral therapy observed in some patients. This review highlights the molecular mechanisms underlying OS in viral hepatitis, its contribution to liver disease progression, and its impact on treatment outcomes. Understanding these mechanisms may open new avenues for therapeutic strategies targeting OS, thereby improving the management of viral hepatitis and associated liver diseases.
YouTube Videos as a Source of Information about Familial Mediterranean Fever: A Reliability and Quality Analysis
(Galenos Yayınevi, 2024) Karakoyun, Ahmet; Çalık, Yalkın
In this study we aimed to investigate the reliability and quality of YouTube videos on familial mediterranean fever (FMF). Materials and Methods: A total of 42 most viewed videos related to FMF were included in this study. The videos included were divided into two groups: professional and non-professional videos. The objective assessment was conducted using two commonly used DISCERN and global quality scale (GQS) instruments. Results: Twenty-nine (69.0%) videos were uploaded by professionals (physicians, health channels) and 13 (31%) videos were uploaded by non-professionals. The mean video length was found as 13.5±12.7 minutes in the professional videos and 6.28±12.6 minutes. Based on the results of the DISCERN scoring, the reliability of the YouTube videos on FMF was poor in 17 (40.5%) videos, moderate in 4 (9.5%) patients, and good in 21 (50%) videos. According to the GQS results, the quality of the videos was poor in 12 (28.6%) videos, moderate in 4 (9.5%) videos, and good in 26 (61.9%) videos. Conclusion: The reliability and quality of videos uploaded by healthcare professionals are higher. Healthcare professionals, including physical therapy and rehabilitation specialists and rheumatologists, should be encouraged to upload reliable video content to appropriately guide patients.
Prognostic value of glucose-to-potassium ratio and other biomarkers in in-hospital cardiac arrest
(MRE Press, 2025) Vişneci, Emin Fatih; Demirci, Osman Lütfi; Tekin, Fatih Cemal; Kadıoğlu, Emine; Mutlu, Hüseyin; Genç, Murat; Bulut, Bensu; Akkan Öz, Medine; Yazıcı, Ramiz
This study aimed to evaluate the prognostic value of the serum glucose/potassium ratio (GPR) for sustained return of spontaneous circulation (ROSC) and 30-day mortality in patients with in-hospital cardiac arrest (IHCA). Methods: Patients aged 18 years or older who underwent cardiopulmonary resuscitation (CPR) for cardiac arrest in the emergency department (ED) were included. Routine laboratory parameters were obtained from the first blood sample collected during CPR in the ED. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were calculated by dividing the absolute number of neutrophils and platelets, respectively, by the absolute number of lymphocytes. The GPR was calculated as serum glucose divided by potassium levels. Results: The 30-day mortality rate was 82.2% (n = 291). Multivariate logistic regression analysis identified lactate, NLR, PLR and GPR as independent predictors of mortality. Among these markers, lactate exhibited the highest predictive power for mortality, with an area under the curve (AUC) of 0.817, compared to NLR (AUC: 0.676), PLR (AUC: 0.679) and GPR (AUC: 0.688). The optimal cut-off values for predicting mortality were 7.83 for lactate (sensitivity: 75.3%, specificity: 89.4%), 1.68 for NLR (sensitivity: 78.8%, specificity: 71.7%), 199.26 for PLR (sensitivity: 76.4%, specificity: 92.3%) and 57.81 for GPR (sensitivity: 71.8%, specificity: 84.1%). Conclusions: Our findings suggest that GPR is a promising prognostic marker for predicting mortality in patients with IHCA.
Predictive factors of mortality in patients with abdominal trauma
(Turkish Association of Trauma and Emergency Surgery, 2025) Turan, Ömer Faruk; Gökdere, Didem Çankaya; Genç, Murat; Bulut, Bensu; Akkanöz Öz, Medine; Mutlu, Hüseyin; Yazıcı, Ramiz
Traumatic injuries, particularly abdominal trauma, are a major cause of mortality worldwide. This study aimed to evaluate predictive factors for mortality and morbidity in abdominal trauma patients using simple, rapid, and accessible clinical and laboratory parameters, with a focus on developing scoring systems for emergency department decision-making. METHODS: A retrospective cohort study was conducted in a Level 1 Trauma Center between October 2022 and March 2024. Patients aged 18 and older with abdominal trauma or multi-trauma were included, while cases with incomplete records, known chronic diseases, or a recent trauma history were excluded. Data on demographics, vital signs, laboratory results, imaging findings, clinical scores, and outcomes were collected. Logistic regression and receiver operating characteristic (ROC) analyses were performed to identify independent mortality predictors and their cut-off values. RESULTS: Out of 693 patients, the mortality rate was 3.6%. The most common mechanisms of trauma were road traffic accidents (59.3%) and falls (23.4%). Independent predictors of mortality included age >= 54 years, Glasgow Coma Scale (GCS) <= 14, Injury Severity Score (ISS) >= 24, and Shock Index >= 1.08. ROC analysis revealed that GCS had the highest predictive value for mortality (area under the curve [AUC]: 0.828), followed by ISS, age, and Shock Index. Elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate, and creatinine were associated with worse outcomes, aligning with findings in the literature. CONCLUSION: Age, GCS, ISS, and Shock Index are strong predictors of mortality in abdominal trauma patients. Integrating these parameters into clinical decision-making can enhance risk stratification and improve patient management. Prospective multicenter studies and national trauma registries are necessary to refine trauma care and reduce mortality rates.
Biomarkers of Vitamin D Sufficiency: Vitamin D Metabolite Levels do not depend on 25-Hydroxyvitamin D2 levels in Healthy Turkish Individuals
(Duzce University, 2025) Yavaş, Cüneyd; Hekim, Nezih; Karcıoğlu Batur, Lütfiye; Eröz, Recep
Patient-specific factors may influence the adequate supplemental vitamin D dose. In this study, we evaluated the relationship between 25(OH)D(2 )and free vitamin D levels and vitamin D deficiency in a healthy Turkish population. Method: Blood samples were obtained from 92 healthy adults aged >= 18 years. Total 25(OH)D was determined by CMIA. Serum 25(OH)D-3 and D(2 )levels were measured by LC-MS. Free 25(OH)D was calculated according to the Bikle method. Results: In 54% of the participants, 25(OH)D(3)levels were below 20 ng/mL. Those with 20 ng/mL or higher had higher mean serum 25(OH)D(3)and free vitamin D levels (P<0.001). Mean 25(OH)D(2)concentration did not differ according to deficiency criteria. Serum 25(OH)D2 levels were consistent regardless of free vitamin D concentrations. Conclusions: Serum 25(OH)D-3 and free vitamin D concentrations measured by LC-MS indicate deficiency by influencing the total 25(OH)D(3)concentration. However, serum 25(OH)D(2 )concentration did not differ between individuals and does not directly indicate deficiency.
Detection of critical coronary artery stenosis through computed tomographic aortogram in patients with suspected aortic dissection
(Bayrakol MP, 2025) Sever, Muhammed Yaşar; Uzun, Nedim; Mutlu, Hüseyin; Erdoğan, Hasan
Aim: Computed tomographic aortography (CTA) is standard for aortic dissection (AD) diagnosis, but not commonly used for acute coronary syndromes. In this study, we aimed to investigate the success of CTA in detecting critical stenosis in coronary arteries in patients with non-ST-elevation myocardial infarction (NSTEMI) diagnosed with suspected AD in the emergency department (ED). Material and Methods: This retrospective study was conducted at a tertiary ED from January 2016 to May 2019. Among 6647 acute chest pain patients undergoing CTA for suspected aortic dissection, 50 NSTEMI cases with conventional coronary angiography (CCA) performed were included. Exclusion criteria included age <18, incomplete records, ST elevation on ECG, or confirmed AD on CTA. CTA was performed using a 64-detector CT scanner, and critical stenosis (>50%) in the coronary arteries was evaluated by a radiologist with eight years of cardiothoracic imaging experience. Results: In this study, 200 coronary arteries of 50 patients were analyzed. Among the 50 patients included in the study, 29 (58%) were male and 21 (42%) female, with a mean age of 61.4 +/- 14.1 years. CTA exhibited a high specificity of 98.71% and sensitivity of 88.89% in detecting critical stenosis within the coronary arteries. A statistically significant positive correlation was observed between the imaging findings of CTA and those of CCA (p<0.001). Discussion: The results indicate that CTA is comparably effective to CCA in identifying critical stenosis within coronary arteries. Moreover, CTA demonstrates potential as an early diagnostic tool for identifying patients with NSTEMI in the ED.
Evaluation of Hemoglobin, Albumin, Lymphocyte, and Platelet Score, Neutrophil-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio in Pediatric Patients with Rotavirus Enteritis
(Erciyes Medical Journal, 2025) Demirtaş, Mehmet Semih; Memiş, Sebahattin; Kocagozoğlu, Sevim Gonca
Objective: Rotavirus enteritis (RV-e) continues to play a major role in hospitalization and morbidity in patients with acute gastroenteritis (AGE). Identifying new biomarkers that can improve risk assessment of RV-e is crucial for effective disease management. This study aimed to evaluate systemic immune/inflammatory index (SII) markers and hemoglobin, albumin, lymphocyte, and platelet score (HALP score) in children with RV-e. Materials and Methods: This retrospective cohort study was conducted in the pediatric emergency outpatient clinic (PEOC) of a tertiary-level training and research hospital, involving 816 patients. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and HALP score were used to evaluate inflammation in cases of rotavirus (RV) and other types of enteritis. Results: A total of 816 patients were included in the study, of whom 45.3% were female and 54.7% were male. The hospitalization rate due to RV-e was higher than that of non- RV-e cases, with 47.5% (n=85) of RV-e patients being hospitalized (p<0.001). Both NLR and PLR was elevated in hospitalized patients within the RV-e group (p<0.001 for both). Hospitalization was found to be 1.45 times more likely (95% confidence interval [CI]: 1.09- 1.94) among patients with low HALP scores, six times more likely (95% CI: 3.52-10.26) in patients with RV-e, and 2.88 times more likely (95% CI: 1.40-5.88) in children under five years of age. Conclusion: This study demonstrated that the frequency of hospitalization increased in patients with low HALP scores. We think that the HALP score may serve as a simple and rapid marker to aid clinicians in early treatment planning, especially for patients diagnosed with RV-e in emergency settings.
Prognostic significance of lactate clearance in severe acute pancreatitis
(Cukurova University, 2025) Yortanlı, Betül Çiğdem; Kollu, Korhan; Kuş, Burcu; Sert, Ekrem Taha; Yortanlı, Mehmet
Purpose: This study aimed to evaluate the prognostic value of lactate clearance in predicting severe acute pancreatitis (SAP) in patients with acute pancreatitis (AP). Identifying early biomarkers for SAP can help in risk stratification and guide clinical management. Materials and Methods: This retrospective, single-center observational study included 183 patients diagnosed with AP between January 2022 and January 2023. Patients were classified as SAP or non-SAP based on the 2012 Atlanta Classification. Demographic data, laboratory parameters, and clinical outcomes were analyzed. Lactate clearance was calculated as [(initial lactate – 24-hour lactate)/initial lactate] × 100.. Results: Among 183 patients, 105 (57.4%) had SAP. SAP patients had significantly longer hospital stays, higher intensive care unit admissions, and increased mortality rates). SAP patients had significantly higher initial and 24- hour lactate levels but lower lactate clearance. Lower lactate clearance was an independent predictor of SAP (OR: 3.051, 95% CI: 2.030–5.072, p<0.001). ROC analysis revealed that lactate clearance had an AUC of 0.835 (95% CI: 0.776–0.894), with 81.9% sensitivity and 76.9% specificity at a cutoff value of 40.9%. Conclusion: Low lactate clearance is strongly associated with SAP development, longer hospitalization, ICU need, and increased mortality. Lactate clearance may serve as a valuable early prognostic marker. Future studies should explore integrating lactate clearance with markers such as SII, SII/albumin ratio, and RDW to enhance risk stratification and clinical decision-making in AP.
The Evaluation of ChatGPT-4's Capacity to Provide Information on Febrile Seizures
(Galenos Publishing House, 2025) Özdemir Kaçer, Emine; Şen, Gürsel
This study aims to evaluate the capacity of ChatGPT-4 to provide accurate and reliable information about febrile seizures, focusing on its ability to deliver educational content and support caregivers and healthcare professionals. Materials and Methods: A total of 30 questions related to febrile seizures were derived from the National Institute of Neurological Disorders and Stroke (NINDS) website. These questions were categorized into five main themes: "overview of febrile seizures," "symptoms and causes," "diagnosis," "treatment and management strategies," and "advice for families." Responses generated by ChatGPT-4 were assessed by experienced pediatricians and neurologists for accuracy and educational value, with results compared against ChatGPT-3.5 and the NINDS guidelines. Results: Of the 30 responses evaluated, 22 were classified as "educationally valuable," 7 as "accurate but insufficient," and 1 as a "mix of correct and outdated information." None of the responses were deemed completely incorrect. In comparison with ChatGPT-3.5, ChatGPT-4 provided "better" responses for 8 questions, "similar" responses for 20, and "worse" responses for 2. Compared to the NINDS guidelines, ChatGPT-4 delivered comparable or superior responses in most cases, except for four questions where the official guidelines performed better due to richer context and graphical support. Conclusion: ChatGPT-4 demonstrates substantial potential as an educational tool for febrile seizures, offering accurate and comprehensible information to caregivers and healthcare professionals. However, limitations such as the lack of detailed explanations and visual aids highlight the need for further development. Future research should explore broader datasets and user feedback to optimize these tools for personalized medical education.
A long noncoding RNA lincRNA EPS expression level in renal anemia in chronic kidney disease
(Bayrakol MP, 2025) Güner, Veysel Berk; Turgut, Faruk; Doğan, Serdar
Chronic Kidney Disease (CKD) is a long-term medical condition characterized by the gradual loss of kidney function over time. Anemia is one of the most important causes of morbidity in patients with CKD. Anemia negatively affects the quality of life and mortality of patients and increases the progression of kidney disease. This is the first study to indicate lincRNA_EPS expression levels in CKD patients with renal anemia. Material and Methods: A total of 59 people were included in this study with 40 patients and 19 control groups. Analyzes of lncRNA expression levels were performed by RT-qPCR method. Total RNA (including miRNA and lncRNA) was obtained from serum and plasma using an RNA isolation kit. Then, RNA concentration and purity were determined spectrophotometrically. The integrity of total RNA was determined by agarose gel electrophoresis. Results: This study concluded that the lincRNA-EPS expression values were found to be significantly higher in the CKD group. There was no statistically significant correlation between the eGFR level of the patients and the lincRNA-EPS expression levels. However, a statistically significant positive correlation was found between eGFR values and hemoglobin levels in the patient group. Discussion: Considering the increased lincRNA-EPS expression level in CKD patients with renal anemia and its inverse correlation with EPO usage, a potential mechanism for facilitating erythropoiesis may involve both elevated lincRNA-EPS expression and suppression of the pro-apoptotic gene Pycard. Larger and more clinical studies are needed to fully elucidate the mechanism of action of the renal anemia-EPOlincRNA-EPS relationship. In the light of these studies, it will be possible to identify new factors that play a role in the formation mechanisms of renal anemia and to evaluate new treatment alternatives.
Evaluation of prognosis in refugee children with high kinetic energy penetrating thoracic gunshot wounds
(Bayrakol MP, 2025) Tuşat, Mustafa; Özmen, İsmail; Demirtaş, Mehmet Semih; Yarbil, Aziz; Calapoğlu, Ahmet Salih; Memiş, Sebahattin
Civil wars cause the death of many innocent children, and penetrating thoracic firearm injury (PTFI) is a leading cause of morbidity and mortality in children in war environments. The aim of this study was to evaluate child casualties admitted to the emergency department with PTFI that occurred on the battlefield. Material and Methods: Our study was conducted by reviewing the files of pediatric patients with PTFI under the age of 18 who were transferred from Syria to the first response hospital on the Syrian border of Turkey due to the Syrian civil war between January 2016 and December 2019. Results: Our study included 28 (84.4%) boys and 5 (15.2%) girls. The cause of injury was a bullet in 5 cases, shrapnel in 28 cases and hemothorax (33.3%) was the most common thoracic injury. It was found that a longer time from injury to presentation to the emergency department (p=0.012, p<0.001), injury with a bullet (p=0.013, p=0.017), the presence of shock at the time of presentation (p<0.001, p=0.001) and an increase in the amount of erythrocyte suspensions given (p<0.001) significantly increased the development of complications and mortality. It was also found that mortality and morbidity were significantly higher in PTFI child casualties with low pediatric trauma score (PTS) (p<0.001). Discussion: Penetrating thoracic injuries in children are still associated with high mortality and morbidity. Rapid transfer of these patients to the hospital, and effective, multidisciplinary resuscitation and aggressive thoracotomy interventions when necessary will reduce mortality in these patients.
Can the halp score, a new prognostic tool, predict the progression of pseudoexfoliation patients to pseudoexfoliation glaucoma?
(Bayrakol MP, 2025) Akbulut Yağcı, Betül; Erdal, Hüseyin
The present study aims to investigate the prognostic role of hemoglobin, albumin, lymphocyte, and platelet (HALP) score in pseudoexfoliation syndrome (PEXS) patients and its relationship with pseudoexfoliation glaucoma (PEXG) progression. Material and Methods: This retrospective study included 58 PEXS and 61 PEXG patients. All groups ' demographic information and hemograms, s were collected from the hospital automation system. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), systemic immuno-inflammatory index (SII), systemic inflammatory response index (SIRI), pan-immune inflammation value (PIV), and HALP were calculated to both groups. The results were compared among the groups. Results: In this study, there were 119 participants in total: 58 patients with PEXS with an average age of 71.3 +/- 8.9 years and 61 patients with PEXG with an average age of 71.3 +/- 8.9 years (p=0.15). In paired comparisons, it was observed that the NLR, PLR, SII, SIRI, and PIV indices of the groups were not found to be statistically significant (p>0.001). The HALP score value was lower in the PEXG group than the PEXS (4.73 +/- 1.99 and 6.3 +/- 2.63, respectively) (p<0.001). The AUC of the HALP score for PEXS and PEXG was 0.696. The optimal cut-off value of HALP to predict PEXG was <= 4.23, with 85% sensitivity and 51.7% specificity (95% confidence interval 0,605-0,777, p<0.01). Discussion: It was found that a lower HALP score was significantly associated with PEXG patients and could be an independent prognostic factor. Although this score alone is not sufficient, this study is important in that it may predict the possibility of developing PEXG.
Radiation and oxidative stress: A mini-review
(Bayrakol Medical Publishing, 2025) Erdal, Hüseyin; Cesur, Turay
Radiation, particularly ionizing radiation used in medical imaging and cancer treatments, induces oxidative stress (OS), a key factor in the biological damage it causes. Radiation interacting with biological tissues generates reactive oxygen species (ROS) that can overwhelm the cell's natural antioxidant defenses. This leads to oxidative damage to essential macromolecules such as DNA, proteins, and lipids, triggering a cascade of harmful cellular events. DNA strand breaks, protein oxidation, and lipid peroxidation are common consequences, contributing to mutations, cellular dysfunction, and apoptosis. These effects play a significant role in both acute radiation injury and long-term health outcomes, such as carcinogenesis and cardiovascular diseases. Given the growing use of radiological procedures in medicine, understanding radiation-induced OS is critical for improving patient safety. Strategies to mitigate oxidative damage, including using antioxidants and radiation dose optimization, are being actively explored. Continued research into the mechanisms of radiation-induced OS is necessary to enhance therapeutic interventions and diagnostic accuracy while minimizing potential risks. This review provides a concise summary of the relationship between radiation and OS.
Performance of the PATHOS score in predicting in-hospital mortality in patients aged 65 years and older admitted to the intensive care unit from the emergency department
(2025) Sert, Ekrem Taha; Kokulu, Kamil
Purpose: The aim of this study was to investigate the performance of the platelets, age, troponin, heart rate, oxygenation, and systolic blood pressure (PATHOS) score in predicting in-hospital mortality among patients aged 65 years and older admitted to the intensive care unit (ICU) from the emergency department (ED). Materials and Methods: This single-center, retrospective observational study included patients aged 65 years and older who presented to the ED and were admitted to the ICU between 2018 and 2024. The PATHOS score was calculated using routine vital signs and blood parameters obtained at ED admission. The patients were divided into two groups: survivors and non-survivors. The predictive power of the PATHOS score for in-hospital mortality was evaluated by comparing these groups. Results: The study included a total of 1,131 patients. The number of survivors was 889 (78.6%), while that of non-survivors was 242 (21.4%). Multivariate logistic regression analysis revealed that the PATHOS score (odds ratio [OR]: 3.80, 95% confidence interval [CI]: 3.07–4.70, p<0.001) independently predicted in-hospital mortality. According to the receiver operating characteristic analysis, the area under the curve of the PATHOS score was 0.827 (0.804–0.849). A PATHOS score greater than 2 predicted in-hospital mortality with a specificity of 75.9% and a sensitivity of 77.6%. Conclusion: The PATHOS score may serve as a valuable tool for predicting in-hospital mortality in geriatric patients admitted to the ICU from the ED. By effectively identifying critically ill elderly patients, this score may facilitate timely ICU transfers and contribute to the more efficient use of limited resources.
Prehospital and emergency data analysis in burn patients: Mortality predictors and response times over five years
(Turkish Association of Trauma and Emergency Surgery, 2025) Bulut, Bensu; Genç, Murat; Öz, Medine Akkan; Yazıcı, Ramiz; Mutlu, Hüseyin; Sert, Ekrem Taha; Kokulu, Kamil; Borazan, İsmail; Turan, Ömer Faruk; Kahraman, Fatih Ahmet; Ay, Serden
Background: This study aimed to retrospectively examine the prehospital and emergency department processes of burn cases to evaluate process effectiveness, establish regional data, and identify factors affecting mortality in burn patients. Methods: The study included 784 burn cases treated by Ankara 112 Emergency Health Services and transferred to Ankara Bilkent City Hospital Emergency Department between January 1, 2019 and December 31, 2023. Demographic data, burn characteristics, response times of 112 emergency health services, and patient outcomes were retrospectively analyzed. Results: The mean age of the patients included in the study was 23.4+-20.7 years, with 36.7% being female. The most common type of burn was hot liquid burns (49.9%) and 73.7% of cases involved second-degree burns. The overall mortality rate was 5%. Logistic regression analysis identified advanced age (odds ratio [OR]: 1.02), presence of inhalation burns (OR: 3.33), and burn percentage as independent risk factors for mortality. Receiver operating characteristic (ROC) analysis showed that age >44 years (38.5% sensitivity, 83.8% specificity) and burn surface >16% (89.7% sensitivity, 77.5% specificity) were predictive thresholds for mortality. Conclusion: Advanced age, extensive burn surface area, residence in rural areas, and inhalation injuries are key predictors of mortality in burn patients. Enhancing prehospital emergency services, implementing community education programs, and adopting a multidisciplinary approach are critical for preventing and effectively managing burn injuries.

Güncel Gönderiler