Thiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera

The present study aims to indicate both thiol-disulfide hemostasis and ischemia-modified albumin (IMA) levels in patients with Polycythemia Vera (PV). Methods: In this prospective case-control study, 34 PV patients and 31 healthy control participants were included. Thi- ol levels were measured with a new modified colorimetric method. IMA levels were determined by cobalt binding test. Results: Thiol levels were statistically significant between the groups. (p<0.001). IMA levels were also significanlty high- er in PV group than healthy control subjects (p<0.001). We revealed that thiol and IMA levels were significantly higher in patients with PV in respect to the control groups. Conclusion: The obtain results indicate that the oxidative balance is disturbed and changed towards the oxidant direc- tion. The dynamic- thiol disulfide balance has moved to proliferation side in patients with PV, and may provide impor- tant contributions to the patient's follow-up and disease pathophysiology.