Thiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera

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dc.authorid0000-0001-5687-8531
dc.authorid0000-0002-6250-5093
dc.authorid0000-0001-7486-503X
dc.contributor.authorErdal, Hüseyin
dc.contributor.authorÇiftçiler, Rafiye
dc.contributor.authorTuncer, Sibel Çiğdem
dc.contributor.authorÖzcan, Oğuzhan
dc.date.accessioned2025-08-01T06:00:32Z
dc.date.available2025-08-01T06:00:32Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractThe present study aims to indicate both thiol-disulfide hemostasis and ischemia-modified albumin (IMA) levels in patients with Polycythemia Vera (PV). Methods: In this prospective case-control study, 34 PV patients and 31 healthy control participants were included. Thi- ol levels were measured with a new modified colorimetric method. IMA levels were determined by cobalt binding test. Results: Thiol levels were statistically significant between the groups. (p<0.001). IMA levels were also significanlty high- er in PV group than healthy control subjects (p<0.001). We revealed that thiol and IMA levels were significantly higher in patients with PV in respect to the control groups. Conclusion: The obtain results indicate that the oxidative balance is disturbed and changed towards the oxidant direc- tion. The dynamic- thiol disulfide balance has moved to proliferation side in patients with PV, and may provide impor- tant contributions to the patient's follow-up and disease pathophysiology.
dc.identifier.doi10.14744/ejmi.2023.39692
dc.identifier.endpage470
dc.identifier.issn2602-3164
dc.identifier.issue4
dc.identifier.startpage466
dc.identifier.urihttps://dx.doi.org/10.14744/ejmi.2023.39692
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13714
dc.identifier.volume7
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErdal, Hüseyin
dc.institutionauthorid0000-0003-0786-5077
dc.language.isoen
dc.publisherKare Yayıncılık
dc.relation.ispartofEurasian Journal of Medical Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPolycythemia Vera
dc.subjectTotal Antioxidant Status
dc.subjectThiol-disulfide Homeostasis
dc.subjectFree Radical
dc.subjectTotal Oxidant Status
dc.subjectIschemia -Modified Albumin
dc.titleThiol-Disulfide Homeostasis and Ischemia Modified Albumin as a New Oxidative Stress Marker in Patients with Polycythemia Vera
dc.typeArticle

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