Extra virgin olive oil mitigates lung injury in necrotizing enterocolitis: Effects on TGFβ1, Caspase-3, and MDA in a neonatal rat model

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dc.authorid0000-0003-2327-4250
dc.authorid0000-0002-5251-2302
dc.authorid0000-0003-2965-1811
dc.contributor.authorTuşat, Mustafa
dc.contributor.authorEröz, Recep
dc.contributor.authorBölükbaş, Ferhan
dc.contributor.authorÖzkan, Erkan
dc.contributor.authorDemirtaş, Mehmet Semih
dc.contributor.authorErdal, Hüseyin
dc.contributor.authorÖzocak, Osman Okan
dc.date.accessioned2025-07-11T06:07:53Z
dc.date.available2025-07-11T06:07:53Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractNecrotizing enterocolitis (NE), which is common in premature babies, has been associated with lung damage. Our aim is to explore the effect of enterally administered extra virgin olive oil (EO) with rich polyphenol content on clinical parameters, histopathological score, Transforming growt factor beta-1 (TGFβ1), Caspase 3 and Malondialdehyde (MDA) levels in NE-related lung injury of neonatal rats. Methods Three groups (control, NE, NE+EO) were created, with 8 neonatal rats in each group. NE was induced by hypoxia-hyperoxia-hypothermia and formula feeding. EO was given to the treatment group by orogastric probe for 3 days. Intestinal and lung tissue were excised for analysis. Results TGFβ1 expression levels, TGFβ1 and MDA concentration levels were higher in the NE compared to NE +  EO and control groups (p < 0.001), and their levels decreased after EO treatment compared to the NE group (p < 0.001). It was determined that EO treatment significantly reduced the histopathological damage and the caspase-3 (CASP3) expression level in the lung (p < 0.001). Conclusion Our findings emphasize that TGFß1 has an crucial function in NE-related lung injury and that EO has therapeutic potential in NE-related lung injury.
dc.identifier.doi10.1371/journal.pone.0320938
dc.identifier.issn19326203
dc.identifier.issue4
dc.identifier.pmid40233022
dc.identifier.scopus105002783255
dc.identifier.urihttps://dx.doi.org/10.1371/journal.pone.0320938
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13252
dc.identifier.volume20
dc.identifier.wos001468674800050
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorTuşat, Mustafa
dc.institutionauthorEröz, Recep
dc.institutionauthorErdal, Hüseyin
dc.institutionauthorBölükbaş, Ferhan
dc.institutionauthorDemirtaş, Mehmet Semih
dc.institutionauthorid0000-0003-2327-4250
dc.institutionauthorid0000-0002-5251-2302
dc.institutionauthorid0000-0003-2965-1811
dc.language.isoen
dc.publisherPublic Library of Science
dc.relation.ispartofPLoS ONE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnimals
dc.subjectNewborn
dc.subjectCaspase 3
dc.subjectDisease Models
dc.subjectAnimal
dc.subjectEnterocolitis
dc.subjectNecrotizing
dc.subjectLung
dc.subjectLung Injury
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectOlive Oil
dc.subjectRats
dc.subjectTransforming Growth Factor beta1
dc.titleExtra virgin olive oil mitigates lung injury in necrotizing enterocolitis: Effects on TGFβ1, Caspase-3, and MDA in a neonatal rat model
dc.typeArticle

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