N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release

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dc.contributor.authorAslanlar, Durmuş Ali
dc.contributor.authorVişneci, Emin Fatih
dc.contributor.authorÖz, Mehmet
dc.contributor.authorAtalık, K. Esra Nurullahoğlu
dc.date.accessioned2024-05-06T12:54:05Z
dc.date.available2024-05-06T12:54:05Z
dc.date.issued2024
dc.departmentTıp Fakültesi
dc.description.abstractMood disorders caused by chemotherapy have become more important as the survival of cancer patients increases, and new studies in this field will contribute to the prevention of this disorder. For this purpose, we used methotrexate, a chemotherapeutic agent frequently preferred in oncological cases. Mtx was administered as a single dose of 100 mg/kg intraperitoneally to male Wistar albino rats. Since oxidative stress plays an important role in chemotherapy-induced emotional impairment, n-acetylcysteine (NAC), a potent antioxidant, was administered at 500 mg/kg in two doses before Mtx administration. We evaluated anxiety and depression-like behaviors 24 h after Mtx administration, as well as some oxidative and inflammatory markers in blood serum and hippocampal tissue, acetylcholinesterase activity (AChE), and brain-derived neurotrophic factor (BDNF) release in hippocampal tissue. In rats, Mtx induced anxiety and depression-like behaviors as well as abnormalities in oxidative and inflammatory markers in blood serum and hippocampal tissue, increased AChE activity in hippocampal tissue, and decreased BDNF release. NAC treatment was found to ameliorate Mtx-induced anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate AChE activity and BDNF release. In conclusion, the fact that NAC treatment of Mtx was effective is important for revising the treatment strategies for individuals suffering from this disorder, and this effect is thought to be related to the antioxidant and anti-inflammatory power of NAC.
dc.identifier.doi10.1016/j.bbr.2023.114740
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549
dc.identifier.pmid37926333
dc.identifier.scopusqualityQ2
dc.identifier.urihttps:/dx.doi.org10.1016/j.bbr.2023.114740
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11783
dc.identifier.volume458en_US
dc.identifier.wosWOS:001113565900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBehavioural Brain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectMethotrexate
dc.subjectN-acetylcysteine
dc.subjectDepression
dc.subjectAnxiety
dc.subjectOxidative stress
dc.subjectInflammation
dc.titleN-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and depression-like behaviors by regulating inflammation, oxidative and cholinergic status, and BDNF release
dc.typeArticle

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