Association Between Plasma Sclerostin Levels and Body Mass Index in Women With Polycystic Ovary Syndrome
Yükleniyor...
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cureus, Inc.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrine pathologies in females of reproductive age worldwide. This study investigated the relationship between serum sclerostin levels and body mass index (BMI) in women with PCOS.MethodsWomen aged 18-40 years who presented to our clinic between January 1, 2019, and January 1, 2020, and were diagnosed with PCOS were included in this study. The patients' clinical and laboratory data were recorded, and waist circumference, hip circumference, and BMI values were calculated. The patients with a BMI of >25 kg/m(2) were evaluated as Group I, those with a BMI of <18.5 kg/m(2) as Group II, and those with a BMI of 18.5-25 kg/m(2) as Group III. Serum sclerostin levels were compared between the BMI groups.ResultsThe study included 90 patients. The mean BMI values were 32.2 +/- 2.1, 17.0 +/- 0.9, and 22.9 +/- 2.1 kg/m(2) for Groups I, II, and III, respectively. We detected a statistically significant difference in serum sclerostin levels between Group II and Group I (p<0.005). There was a significant, positive correlation between the sclerostin level and BMI (r=0.258, p=0.014), weight (r=0.237, p=0.044), waist measurement (r=0.225, p=0.045), and hip measurement (r=0.225, p=0.033).ConclusionThis study revealed that abnormal body composition in PCOS could alter circulating sclerostin levels.
Açıklama
Anahtar Kelimeler
Women, Sclerostin, Polycystic Ovary Syndrome, Patients, Body Mass Index
Kaynak
The Cureus Journal of Medical Science
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
15
Sayı
11
