Research on the effects of levetiracetam in spinal cord injury model in rats: An experimental study

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dc.contributor.authorNursoy, Egemen
dc.contributor.authorÖgden, Mustafa
dc.contributor.authorBakar, Bülent
dc.contributor.authorDinçel, Güngör Çağdaş
dc.contributor.authorKısa, Üçler
dc.contributor.authorÖzveren, Mehmet Faik
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:26:19Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:26:19Z
dc.date.issued2020
dc.departmentEskil Meslek Yüsekokulu
dc.description.abstractPurpose: Despite advances in spinal biomechanic research, surgical techniques, and rehabilitation processes, no significant improvement has been identified in the treatment of spinal cord injury (SCI) and neurological recovery. Aim of the Study: This study was designed to investigate the potential therapeutic effects of methylprednisolone and levetiracetam on SCI. Materials and Methods: In this study, 42 male Wistar Albino rats, each weighing 300–350 g, were separated into three main groups: control group, acute and subacute stage groups. With the exception of the control group, a T7-8 dorsal laminectomy was performed on the spinal column of the rats. A temporary vascular aneurysm clip was then applied to the spinal cord for 1 min to create SCI and methylprednisolone or levetiracetam was administered intraperitoneally to all except the control and SHAM control groups. The damaged spinal cord was removed for histopathological and biochemical examinations. Results: Both pharmacological agents were determined to have improved the histopathological architecture in damaged neural tissues during the acute period of SCI, but could not sustain this activity in the subacute period. Neither pharmacological agent affected the biochemical data in the acute nor subacute stages. Conclusions: Both pharmacological agents showed histopathological healing effects in injured tissues during the acute phase of SCI in this rat model but these effects could not be sustained in the subacute period. No effect on biochemical data was seen in either the acute or subacute period. There is a need for further advanced studies to determine the effects of levetiracetam on the healing processes in SCI. © 2018, Copyright © 2018 Taylor & Francis Group, LLC.
dc.identifier.doi10.1080/08941939.2018.1490828
dc.identifier.issn0894-1939
dc.identifier.pmid30204031
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://dx.doi.org/10.1080/08941939.2018.1490828
dc.identifier.urihttps://hdl.handle.net/20.500.12451/3149
dc.identifier.wosWOS:000509677900006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLevetiracetam
dc.subjectMethylprednisolone
dc.subjectSpinal Cord
dc.subjectSpinal Cord İnjury
dc.titleResearch on the effects of levetiracetam in spinal cord injury model in rats: An experimental study
dc.typeArticle

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