Role of nitric oxide and oxidative stress in pathophysiology of liver injury in streptozotocin-induced type 1 diabetic rats

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dc.contributor.authorDinçel, Güngör Çağdaş
dc.contributor.authorYıldırım, Serkan
dc.contributor.authorKul, Oğuz
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T08:38:31Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T08:38:31Z
dc.date.issued2018
dc.departmentMeslek Yüksekokulu
dc.description.abstractType 1 diabetes mellitus (T1DM) is a severe chronic metabolic disorder characterized by hyperglycaemia because of the alterations in insulin secretion or its action. It is previously shown that hyperglycemia related oxidative stress (OS) and excessive nitric oxide (NO) production may cause severe complications in kidney and brain. In this report, it is aimed to investigate the cytotoxic effects of NO and to evaluate possible interaction with T1DM related hepatopathology. Expression levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), Cu/Zn superoxide dismutase (SOD1) and glutathione reductase (GR) were examined by immunohistochemistry in liver tissues. Results of the study revealed that levels of 8-OHdG (P<0.001), eNOS (P<0.001), eNOS (P<0.001), SOD1 (P<0.001) and GR (P<0.001) were remarkably higher in liver with T1DM than control. The most prominent finding of this study is the increased levels of 8-OHdG in the mostly hepatocyte cytoplasm. These results suggest an involvement of oxidative DNA damage and OS might play a pivotal role on hepatic degeneration and this is a novel insight of pathogenesis on the explanation of cellular processes in streptozotocin (STZ)-induced type 1 diabetic rats'liver. Furthermore, these results also suggested that STZ-induced hepatic pathology might have been augmented by the contribution of high NO expression mediated OS. Taken together, the results suggest NO related hepatic inflammation and degeneration closely implicated in pathophysiology of T1DM. The results also clearly indicated that OS plays an important role on hepatic pathology and OS biomarkers might indicate the progress of the T1DM.
dc.description.sponsorshipScientific Research Projects Commission of the Gumushane University, Turkey [15.B0421.02.2]
dc.description.sponsorshipThis work was funded and supported by the Scientific Research Projects Commission of the Gumushane University, Turkey (Project Code: 15.B0421.02.2). This study was presented as an oral presentation in the 32nd World Veterinary Congress, 13-17 September 2015, Istanbul.
dc.identifier.doi10.1501/Vetfak_0000002825
dc.identifier.endpage50en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage39en_US
dc.identifier.urihttps://doi.org/10.1501/Vetfak_0000002825
dc.identifier.urihttps://hdl.handle.net/20.500.12451/3759
dc.identifier.volume65en_US
dc.identifier.wosWOS:000416989900006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherChartered Inst. of Building Services Engineers
dc.relation.ispartofAnkara Üniversitesi Veteriner Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHepatopathology
dc.subjectNitric Oxide
dc.subjectOxidative Stress
dc.subjectType 1 Diabetes Mellitus
dc.titleRole of nitric oxide and oxidative stress in pathophysiology of liver injury in streptozotocin-induced type 1 diabetic rats
dc.typeArticle

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