A new pollen-derived microcarrier for pantoprazole delivery

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dc.authoridSargin, Idris -- 0000-0003-3785-9575; Kaya, Murat -- 0000-0001-6954-2703
dc.contributor.authorAkyüz, Lalehan
dc.contributor.authorSargın, İdris
dc.contributor.authorKaya, Murat
dc.contributor.authorCeter, Talip
dc.contributor.authorAkata, Ilgaz
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:27:32Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:27:32Z
dc.date.issued2017
dc.departmentAksaray Teknik Bilimler Meslek Yüksekokulu
dc.description.abstractPlant-derived carriers have emerged as promising materials for drug encapsulation. Especially, sporopollenin microcapsules extracted from diverse pollen species have been proved to be effective drug carriers due to their biocompatibility, homogeneity in size, resistance to harsh chemical conditions and high thermal stability. Here in this study, sporopollenin microcapsules were isolated successfully from the pollens of a common tree (Cotylus avellana, the European hazelnut) and used as a carrier for pantoprazole (PaNa) (a proton pump inhibitor). The drug entrapment efficiency was recorded as 29.81%. SEM micrographs clearly showed the drug was loaded into the microcapsules through the apertures of microcapsule and also some drugs were adsorbed on the surface of microcapsules. FT-IR spectra analysis confirmed the drug loading. Thermogravimetric analysis revealed that thermal stability of PaNa was enhanced by encapsulation. In vitro release studies showed that PaNa-loaded sporopollenin microcapsules exhibited better release performance than the control. C. avellana sporopollenin micro capsules can make an efficient carrier for delivery of PaNa. (C) 2016 Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.msec.2016.11.009
dc.identifier.endpage942en_US
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid27987792
dc.identifier.scopusqualityN/A
dc.identifier.startpage937en_US
dc.identifier.urihttps://doi.org/10.1016/j.msec.2016.11.009
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5883
dc.identifier.volume71en_US
dc.identifier.wosWOS:000390967200109
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofMaterials Science & Engineering C-Materials for Biological Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectProton Pump İnhibitor
dc.subjectDelayed-Release
dc.subjectColon Delivery
dc.subjectHazelnut Pollen
dc.subjectKinetics
dc.titleA new pollen-derived microcarrier for pantoprazole delivery
dc.typeArticle

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