Evaluation of metabolic stress status in common carp (Cyprinus carpio) exposed to the fungicide folpet

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dc.contributor.authorAcar, Ümit
dc.contributor.authorErden, Yavuz
dc.contributor.authorİnanan, Burak Evren
dc.contributor.authorKesbiç, Osman Sabri
dc.contributor.authorYılmaz, Sevdan
dc.contributor.authorÇelik, Ekrem Şanver
dc.date.accessioned2023-01-23T06:27:44Z
dc.date.available2023-01-23T06:27:44Z
dc.date.issued2023
dc.departmentEskil Meslek Yüksekokulu
dc.description.abstractAmong pesticides, fungicides are the most extensively used ones in agriculture and their effects on fish health and indirectly human health are needed to evaluate. Folpet has been used for over 50 years as a fungicide across the world. The mechanism of action of folpet on non-target aquatic organisms is so poorly understood and there is no available information about potential acute toxicity of folpet and its mechanism of action in non-target aquatic organisms. With this motivation, two successive experiments were set up: first, 96 h-LC50 value of folpet for common carp (Cyprinus carpio) was determined; and second, effects of different sublethal concentrations (0, 0.025, 0.50, 0.1 and 0.15 mg/L) of folpet on hematological serum biochemical blood parameters, DNA damages, expression levels of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione Stransferase (GST), and cortisol receptor (HSP70) genes were evaluated in this study. It was calculated that 0.199 mg/L of folpet was the 96 h-LC50 value. After the folpet exposure for 14 days, significant decreases in red blood cells, hemoglobin, hematocrit, serum total protein, and GST gene expression levels were observed while serum glucose, liver enzymes activities, and expression levels of CAT, SOD, GPx, HSP70 genes increased. Also, folpet induced a significant genotoxic effect on the blood cells regarding to DNA damages. Consequently, the results have shown the toxic effects of folpet even at the lowest concentration on common carp.
dc.identifier.doi10.1016/j.cbpc.2022.109494
dc.identifier.pmid36283647
dc.identifier.scopusqualityN/A
dc.identifier.urihttps:/dx.doi.org/10.1016/j.cbpc.2022.109494
dc.identifier.urihttps://hdl.handle.net/20.500.12451/10002
dc.identifier.volume263en_US
dc.identifier.wosWOS:000880404000004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofComparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectFolpet
dc.subjectGenotoxicity
dc.subjectComet Assay
dc.subjectGene Expression
dc.subjectCyprinus Carpio
dc.titleEvaluation of metabolic stress status in common carp (Cyprinus carpio) exposed to the fungicide folpet
dc.typeArticle

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