The effect of dutasteride on microscopic and macroscopic changes of testosterone replacement treatment on prostate tissue

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dc.authoridDiri, Mehmet Akif -- 0000-0002-0413-4802
dc.contributor.authorDiri, Mehmet Akif
dc.contributor.authorDiri, Banu
dc.contributor.authorYıldız, Levent
dc.contributor.authorBüyükalpelli, Recep
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:16:49Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:16:49Z
dc.date.issued2018
dc.departmentTıp Fakültesi
dc.description.abstractTestosterone replacement therapy has a growing interest in daily practice; however, debates on its safety for prostate cancer still continue. Dutasteride-a 5 alpha-reductase inhibitor-was shown to be effective in preventing prostate cancer. We therefore aimed to evaluate the effect of testosterone replacement therapy and dutasteride treatment on prostate tissue in castrated rats. Rats were randomised in four groups after bilateral orchidectomy as follows: Group I received testosterone + dutasteride, Group II received only testosterone, Group III had no medical treatment, and Group IV was the control group. After 3 months, rats were sacrificed and laboratory and histopathological examinations were performed. In Groups I and II, prostate volume, T and DHT levels were significantly higher compared to Group III and controls. Groups I and II had also significantly greater preneoplastic histopathological signs; however, in intergroup analyses, Group I showed less premalignant changes compared to Group II. We concluded that dutasteride was effective when combined with testosterone therapy in preventing premalignant histopathological changes in prostate tissue. Further evidence is needed to confirm our findings.
dc.identifier.doi10.1111/and.13110
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue10en_US
dc.identifier.pmid30024036
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1111/and.13110
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4657
dc.identifier.volume50en_US
dc.identifier.wosWOS:000451785300010
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWıley
dc.relation.ispartofAndrologıa
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDihydrotestosterone
dc.subjectDutasteride
dc.subjectProstate Cancer
dc.subjectTestosterone
dc.titleThe effect of dutasteride on microscopic and macroscopic changes of testosterone replacement treatment on prostate tissue
dc.typeArticle

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