Toxic effects of the synthetic pyrethroid permethrin on the hematological parameters and antioxidant enzyme systems of the freshwater fish Cyprinus carpio L

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dc.authorid0000-0001-8299-910X
dc.authorid0000-0002-4485-9947
dc.authorid0000-0002-7099-5969
dc.contributor.authorKorkmaz, Nuh
dc.contributor.authorUğurer, Orhan
dc.contributor.authorÖrün, İbrahim
dc.date.accessioned2023-10-02T06:57:51Z
dc.date.available2023-10-02T06:57:51Z
dc.date.issued2023
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractThis study investigated changes in hematological and antioxidant parameters of carp exposed to two different doses of synthetic pyrethroid permethrin (control, vehicle, 10 ppm, and 20 ppm) for two different periods (4 days and 21 days). Hematological analyses were then performed on a veterinary Ms4 (Melet Schloesing, France) blood counter using commercially available kits (Cat. No. WD1153). Buege and Aust for MDA, Luck for CAT, McCord and Frivovich for SOD, Lawrence and Burk methods for GSH-Px were used to determine antioxidant parameters. Decreases in RBC count, Hb amount, Hct value, granulocyte ratios, and increases in total WBC and lymphocyte ratios were statistically significant in both dose groups treated with permethrin compared to the control group (p < 0.05). However, there was no statistically significant difference in monocyte ratios (p > 0.05). Overall, permethrin exposure caused an increase in MDA levels in the liver and gill tissues of carp in both dose and duration groups compared to the control group. Also, no statistically significant difference between the two dose groups in the liver tissue was observed in terms of duration (p > 0.05). Nonetheless, the increase in MDA levels in PERM10 and PERM20 dose groups in the gill tissues over 21 days was statistically significant (p < 0.05). Furthermore, permethrin exposure increased CAT, SOD, and GSH-Px enzyme activities in the gill tissue, while impacting in the opposite direction the liver tissue. Finally, regarding MDA, CAT, SOD, and GSH-Px levels, the control, and control acetone dose groups of all experimental groups were observed to be similar (p > 0.05). As a result, permethrin produced a toxic effect on Cyprinus carpio, triggering changes in blood parameters and inducing the antioxidant enzyme system.
dc.identifier.doi10.1007/s10646-023-02675-2
dc.identifier.endpage655en_US
dc.identifier.issn0963-9292
dc.identifier.issue5en_US
dc.identifier.pmid37300635
dc.identifier.scopusqualityQ2
dc.identifier.startpage646en_US
dc.identifier.urihttps:/dx.doi.org10.1007/s10646-023-02675-2
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11027
dc.identifier.volume32en_US
dc.identifier.wosWOS:001004105500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherECOTE
dc.relation.ispartofEcotoxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAntioxidant Enzymes
dc.subjectCyprinus Carpio
dc.subjectHematological Parameters
dc.subjectPermethrin
dc.titleToxic effects of the synthetic pyrethroid permethrin on the hematological parameters and antioxidant enzyme systems of the freshwater fish Cyprinus carpio L
dc.typeArticle

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