The protective effect of platelet rich plasma against cisplatin-Induced ototoxicity

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dc.contributor.authorYurtsever, Kum Nurcan
dc.contributor.authorBaklacı, Deniz
dc.contributor.authorGüler, İsmail
dc.contributor.authorKuzucu, İhsan
dc.contributor.authorKum, Oğuzhanrauf
dc.contributor.authorUçaryılmaz Özhamam, Esra
dc.contributor.authorÖzcan, Müge
dc.contributor.authorDere, Hüseyin Hüseyin
dc.date.accessioned2020-09-22T05:50:43Z
dc.date.available2020-09-22T05:50:43Z
dc.date.issued2020
dc.departmentTıp Fakültesi
dc.descriptionKuzucu, İhsan ( Aksaray, Yazar )
dc.description.abstractCisplatin, a pharmacological agent widely used for treating many cancers, may cause serious side effects including ototoxicity, nephrotoxicity, and peripheral neuropathy. The present study aimed to investigate whether platelet-rich plasma (PRP) protects against cisplatin ototoxicity. Eight rats (16 ears) were divided into 2 groups: control group (4 rats, 8 ears) that received intratympanic saline and study group (4 rats, 8 ears) that received intratympanic PRP. Cisplatin (10 mg/day intraperitoneally) or vehicle was administered 2 times per day to the animals. Auditory brainstem responses were recorded preoperatively and postoperatively on day 4 and at week 3. The authors compared the morphological appearances of spiral ganglion cells and the organ of Corti and the density of spiral ganglion cells between treatment groups. The number of outer hair cells in the organ of Corti significantly decreased in the control group compared with that in the PRP group. Although no statistically significant difference was observed between the groups regarding ABR thresholds on day 4 (P?=?0.083, a statistically significant difference was observed between groups at week 3 (P?=?0.038). Our results suggest that PRP can prevent cisplatin-induced ototoxicity.
dc.identifier.doi10.1097/SCS.0000000000006645
dc.identifier.endpagee509en_US
dc.identifier.issn1536-3732
dc.identifier.issue5en_US
dc.identifier.pmid32541270
dc.identifier.scopusqualityQ3
dc.identifier.startpagee506en_US
dc.identifier.urihttps:/dx.doi.org/10.1097/SCS.0000000000006645
dc.identifier.urihttps://hdl.handle.net/20.500.12451/7678
dc.identifier.volume31en_US
dc.identifier.wosWOS:000600784100029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofThe Journal of craniofacial surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectThe Protective Effect of Platelet Rich Plasma Against
dc.titleThe protective effect of platelet rich plasma against cisplatin-Induced ototoxicity
dc.typeArticle

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