Synthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers

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dc.authorid0000-0003-1864-5694
dc.authorid0000-0003-2614-9914
dc.authorid0000-0002-1414-4465
dc.contributor.authorAcet, Ömür
dc.contributor.authorKirsanov, Pavel
dc.contributor.authorAcet, Burcu Önal
dc.contributor.authorHalets-Bui, Inessa
dc.contributor.authorShcharbin, Dzmitry
dc.contributor.authorCömert, Seyda Ceylan
dc.contributor.authorOdabaşı, Mehmet
dc.date.accessioned2024-11-14T08:37:09Z
dc.date.available2024-11-14T08:37:09Z
dc.date.issued2024
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractNanopolymers represent a significant group of delivery vehicles for hydrophobic drugs. In particular, dual stimuli-responsive smart polymer nanomaterials might be extremely useful for drug delivery and release. We analyzed the possibility to include the known antitumor drug doxorubicin (DOX), which has antimitotic and antiproliferative effects, in a nanopolymer complex. Thus, doxorubicin-loaded temperature- and pH-sensitive smart nanopolymers (DOX-SNPs) were produced. Characterizations of the synthesized nanostructures were carried out including zeta potential measurements, Fourier-transform infrared spectroscopy, and scanning electron microscopy. The loading capacity of the nanopolymers for DOX was investigated, and encapsulation and release studies were carried out. In a final step, the cytotoxicity of the DOX-nanopolymer complexes against the HeLa cancer cell line at different concentrations and incubation times was studied. The DOX release depended on temperature and pH value of the release medium, with the highest release at pH 6.0 and 41 degrees C. This effect was similar to that observed for the commercial liposomal formulation of doxorubicin Doxil. The obtained results demonstrated that smart nanopolymers can be efficiently used to create new types of doxorubicin-based drugs.
dc.identifier.doi10.3762/bjnano.15.96
dc.identifier.endpage1196en_US
dc.identifier.issn2190-4286
dc.identifier.issue-en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1189en_US
dc.identifier.urihttps:/dx.doi.org/10.3762/bjnano.15.96
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12639
dc.identifier.volume15en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBeilstein-Institut
dc.relation.ispartofBeilstein Journal of Nanotechnology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectCancer Cell Line HeLa
dc.subjectCytotoxicity
dc.subjectDoxorubicin
dc.subjectDrug Delivery
dc.subjectSmart Nanopolymers
dc.subjectTemperature- and pH-sensitive Nanopolymer
dc.titleSynthesis, characterization and anticancer effect of doxorubicin-loaded dual stimuli-responsive smart nanopolymers
dc.typeArticle

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