A simple route for the synthesis of novel norcantharimide derivatives via acidolysis with hydrochloric acid(gas)
| dc.contributor.author | Köse, Aytekin | |
| dc.date.accessioned | 2021-07-02T07:10:05Z | |
| dc.date.available | 2021-07-02T07:10:05Z | |
| dc.date.issued | 2021 | |
| dc.department | Sabire Yazıcı Fen Edebiyat Fakültesi | |
| dc.description.abstract | Abstract Indexed keywords SciVal Topics Chemicals and CAS Registry Numbers Funding details Abstract In this work, seven new norcantharimide derivatives were synthesized by an acidolysis method. The compounds were prepared by acidolyzing trans-1,4-diacetate and trans-1,2-chloroacetate structures, which were obtained by stereospecific cleavage of the internal etheric bond of the tricyclic imides. The HCl(gas) was produced from the reaction of H2SO4 with NaCl. The resulting gas was bubbled into the reaction mixture. Trans-1,4-diacetate and trans-1,2-chloroacetate were thus acidolyzed, and the corresponding diol and halohydrin products were obtained respectively in moderate overall yields from low-cost starting materials, using simple and easily scalable chemistry. The products were characterized by means of spectroscopic techniques. The synthesized compounds have high potential as anticancer agents and can be valuable for studies in this area. | |
| dc.identifier.doi | 10.1002/jhet.4248 | |
| dc.identifier.endpage | 1178 | en_US |
| dc.identifier.issue | 5 | en_US |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.startpage | 1171 | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1002/jhet.4248 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/8279 | |
| dc.identifier.volume | 58 | en_US |
| dc.identifier.wos | WOS:000624895200001 | |
| dc.identifier.wosquality | Q3 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.language.iso | en | |
| dc.publisher | HeteroCorporation | |
| dc.relation.ispartof | Journal of Heterocyclic Chemistry | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/embargoedAccess | |
| dc.subject | A Simple Route for the Synthesis of Novel | |
| dc.title | A simple route for the synthesis of novel norcantharimide derivatives via acidolysis with hydrochloric acid(gas) | |
| dc.type | Article |
