A simple route for the synthesis of novel norcantharimide derivatives via acidolysis with hydrochloric acid(gas)
Yükleniyor...
Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
HeteroCorporation
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
Abstract Indexed keywords SciVal Topics Chemicals and CAS Registry Numbers Funding details Abstract In this work, seven new norcantharimide derivatives were synthesized by an acidolysis method. The compounds were prepared by acidolyzing trans-1,4-diacetate and trans-1,2-chloroacetate structures, which were obtained by stereospecific cleavage of the internal etheric bond of the tricyclic imides. The HCl(gas) was produced from the reaction of H2SO4 with NaCl. The resulting gas was bubbled into the reaction mixture. Trans-1,4-diacetate and trans-1,2-chloroacetate were thus acidolyzed, and the corresponding diol and halohydrin products were obtained respectively in moderate overall yields from low-cost starting materials, using simple and easily scalable chemistry. The products were characterized by means of spectroscopic techniques. The synthesized compounds have high potential as anticancer agents and can be valuable for studies in this area.
Açıklama
Anahtar Kelimeler
A Simple Route for the Synthesis of Novel
Kaynak
Journal of Heterocyclic Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
58
Sayı
5
