Effects of coadministration of foot and mouth disease vaccine and inactivated parapoxvirus ovis on humoral immunity in cattle

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dc.contributor.authorCanbar, R.
dc.contributor.authorUslu, M.
dc.date.accessioned2025-07-18T06:15:48Z
dc.date.available2025-07-18T06:15:48Z
dc.date.issued2025
dc.departmentVeteriner Fakültesi
dc.description.abstractFoot and mouth disease (FMD) is an acute viral disease in animals. Inactive parapoxvirus ovis (IPPVO) strengthens humoral immunity. This study aimed to determine the effect of IPPVO application together with FMD vaccine on cattle immunity. It included 30 Holstein cattle randomly divided into two groups: one was administered only the FMD vaccine, and the other was administered the FMD vaccine and IPPVO simultaneously. Control blood was collected from all animals at 0 hours. Serum TNF-α, IL-1β, and IL-6 levels were measured in blood samples collected at 4, 8, 12, 16, and 24 hours post-vaccination, while serum IgG and IgM levels were measured in blood samples collected at 4, 8, 12, 16, and 20 days post-vaccination using ELISA kits. While no changes in serum TNF-α, IL-1β, and IL-6 levels were detected in the FMD group, IL-1β levels significantly increased (peaking at four hours) in the FMD + IPPVO group. In the FMD group, while IgG levels increased significantly (peaking at 16 days), IgM levels did not change. In the FMD + IPPVO group, IgG level on day 8 days was higher than the 16 days value. Also, the IgM level increased significantly on day 16. In conclusion, the application of FMD with IPPVO increases the primary immune response (IgM), but it does not effect the long-term immune response (IgM).
dc.identifier.doi10.24425/pjvs.2025.154941
dc.identifier.endpage231
dc.identifier.issn15051773
dc.identifier.issue2
dc.identifier.pmid40556536
dc.identifier.scopus105008901136
dc.identifier.startpage225
dc.identifier.uri10.24425/pjvs.2025.154941
dc.identifier.urihttps://hdl.handle.net/20.500.12451/13369
dc.identifier.volume28
dc.identifier.wosWOS:001514543200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorCanbar , R.
dc.language.isoen
dc.publisherPolska Akademia Nauk
dc.relation.ispartofPolish Journal of Veterinary Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCtokine
dc.subjectFMD Vaccine
dc.subjectImmunoglobulin
dc.subjectInactive Parapoxvirus Ovis
dc.titleEffects of coadministration of foot and mouth disease vaccine and inactivated parapoxvirus ovis on humoral immunity in cattle
dc.typeArticle

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