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Hipofiz adenomuna endoskopik endonazal transsfenoidal cerrahi yaklaşım
(PLEKSUS BİLİŞİM TEKN.DANIŞ.TEMS.YAY.ORG.A.Ş., 2020) Kuran, Gökhan; Abeş, Derya; Özdaş, Talih; Görgülü, Orhan; Gezercan, Yurdal
Bu çalışmanın amacı; endoskopik endonazal transsfenoidal yaklaşımla hipofiz adenomu cerrahisi yapılan hasta sonuçlarımızı literatür eşliğinde tartışmaktır. Gereç ve Yöntem: Adana Şehir Eğitim ve Araştırma Hastanesi'nde 2017-2018 tarihleri arasında hipofiz adenomu nedeniyle cerrahi planlanan ve KBB kliniğimizin beyin ve sinir cerrahisi kliniği ile birlikte endoskopik endonazal transsfenoidal cerrahi yaptığı 30 hasta retrospektif olarak incelendi. Hastaların dosyaları incelenerek yaş, cinsiyet, başvuru şikayetleri, preoperatif laboratuvar ve görüntüleme bulguları, patoloji raporları, hastanede yatış süreleri, postoperatif komplikasyonlar, postoperatif laboratuvar ve görüntüleme bulguları değerlendirildi. Bulgular: Çalışmaya alınan 30 hastanın 19'u kadın, 11'i erkekti. Hastaların ortalama yaşı 43,86± 15,24 idi. Adenomların 24(%80) tanesi makroadenom, 6 (%20)'sı mikroadenomdu. Hastaların 26(%86,7)'sında total rezeksiyon saptanırken, 4 (%13,3) tanesinde rezidü doku saptandı. Fonksiyonel adenomların 15 (%78,9) tanesinde postoperatif hormonal remisyon sağlandığı, 4 (%21) tanesinde hormonal remisyon sağlanamadığı görüldü. Hastaların postoperatif geç dönemde çekilen MRG'lerinde 2 (%6,7) hastada nüks görüldü. Sonuç: Hipofiz adenomlarının cerrahi tedavisinde endoskopik endonazal transsfenoidal cerrahinin en etkili, çevre dokulara en az zarar veren ve ameliyat sırasında en iyi görüş sağlayan yöntem olduğu düşünülmektedir.
A study of obesity prevalence in the rural population in Turkey: Güzelyurt (Aksaray) example
(Galenos Yayınevi, 2020) Işıklar Özberk, Derya; Özberk, Ömer
Obesity is a common health problem in almost allsocieties. The aim of this study was to investigate obesity in ruralareas.Methods: Descriptive, cross-sectional study included patients whoapplied to Güzelyurt District Hospital in September-November2018 for any reason over 18 years of age. Body weight, height, bodymass index (BMI), waist/hip circumference ratio (WHR), waistto-height ratio (WHtR), and blood pressure measurements wereevaluated. In addition, age, gender, marital status, education level,occupation, smoking habits, the disease was diagnosed, whether thedrug was recorded.Results: The mean age of the 191 participants was 46.8±15.6 years,79.1% were female, 36.6% were primary school graduates, 72.8%were housewives, 85.9% living in town or village. The frequencyof obesity 46.6%, 51.7% in females, 27.5% in males. Abdominalobesity; according to WC, 25.0% males, 68.2% females, accordingto WHR, 70.0% males, 57.6% females, and according to WHtR,77.5% males and 90.7% females. There was a moderate positivecorrelation between the age and BMI. BMI was strong positivelysignificantly correlated with WHtR, WC and HC, a weakercorrelation between BMI to NC and WHR.Conclusion: The prevalence of obesity was 46.6%. It is possibleto say that such a high rate in living conditions does not allow sedentary life and families with low socioeconomic status have sucha high rate. Obesity is health problem of our age in rural areas.
Kobi’lerde üretim ve pazarlama sorunları: Ostim örneği
(Türk Kooperatifçilik Kurumu, 2019) Şahin, B. Deniz; Özüdoğru, Haşim
KOBİ’ler gerek Türkiye gerek dünya ülkelerin de ekonominin temelini oluşturmaktadır. Ülkemizdeki istihdam oranı, ekonomiye katkı payları ve ihracat payları ile önemli bir yere sahiptirler. Bu çalışma iki aşamadan oluşmaktadır. İlk aşamada KOBİ tanımları, özellikleri, ülke ekonomisindeki yeri ve üretim, pazarlama, finansman, personel vb sorunları incelenmiştir. İkinci aşamada ise Ankara ili Ostim Bölgesinde yer alan Medikal Küme İşletmelerinin üretim ve pazarlama sorunlarına yönelik anket çalışması ile sorunlarının tespit edilmeye çalışılmıştır. Ankara ili Ostim bölgesinde medikal sektörde faaliyet gösteren sorunlarını tespit etmek amacıyla, iletişim bilgilerine ulaşılan 43 firmaya anket formları iletilmiştir. Anket formu ile elde edilen veriler düzenlenerek MS. Excel ve SPSS 19 yardımı ile analiz edilmiştir. Yapılan analizlerin sonucunda elde edilen veriler ile en sık karşılaşılan pazarlama ve üretim sorunlarına ulaşılmıştır. Sonuçlar doğrultusunda çözüm önerileri getirilmiştir.
Akut Stent Trombozu Gelişimi ile Serum Trigliserid Seviyeleri Arasındaki İlişkinin Değerlendirilmesi
(Mebas Medikal Basın Yayın San. ve Tic. Ltd. Şti, 2019) Gül, Murat; Acar, Burak; Şahan, Ekrem; İnci, Sinan
Akut stent trombozu, işlemin ilk 24 saati içinde gelişen miyokard enfarktüsü ve ani ölümle ilişkili olabilen perkütan koroner girişiminölümcül bir komplikasyonudur. Dislipidemi kardiyovasküler hastalıklar için iyi bilinen bir risk faktörüdür. Etkin statin tedavisiyle hedefdüşük yoğunluklu lipoprotein kolesterol değerlerine ulaşılmasına rağmen rezidü risk yüksek kalmaya devam etmektedir. Bu çalışmada perkütankoroner girişim yapılan stabil koroner arter hastalarında stent trombozu ile başvuru esnasındaki trigliserid değeri arasındaki ilişkiyiaraştırmayı amaçladık.Gereç ve Yöntem: Stabil koroner arter hastalığı sebebiyle Ocak 2013 ile Aralık 2017 aralığında koroner anjiografi yapılan toplamda7.512 hasta retrospektif olarak değerlendirildi. Hastane içi akut stent trombozu gelişen toplamda 122 hasta tanımlandı. Teknik sebeplerebağlı stent trombozu geliştiği düşünülen (sınır diseksiyonu, undersize stent seçimi, yetersiz stent ekspansiyonu vs.) 24 hasta çalışmadışında bırakıldı. Akut stent trombozu gelişen 98 hasta ve kontrol grubu olarak 502 hasta çalışmaya dahil edildi. Akut stent trombozunuöngörmede trigliserid düzeylerinin prediktif değeri araştırıldı.Bulgular: Stent trombozu gelişen grupta kontrol grubuna kıyasla stent uzunluğu, total kolesterol, trigliserid seviyesi,düşük yoğunluklu lipoproteinkolesterol seviyesi, beyaz küre sayısı, fibrinojen ve ürik asit seviyesi kontrol grubuna göre anlamlı olarak daha fazla saptandı.Yapılan çok değişkenli regresyon analizinde stent uzunluğu, fibrinojen, ürik asit, beyaz küre sayısı ve trigliserid seviyeleri akut stent trombozunuöngörmede bağımsız değişkenler olarak bulundu.Sonuç: Artmış trigliserid seviyeleri, elektif perkütan koroner girişim sonrası akut stent trombozunu öngörmede önemli bir değişken olarakbulundu. Stent trombozuyla ilişkili olduğu bilinen klinik ve anjiyografik parametrelere bu laboratuvar bulgusunun da dahil edilmesi,stent trombozu açısından yüksek riskli hastaların belirlenmesine katkı sağlayabilir.
Biomechanical comparison of a new handy tension band with malleolar screw, bicortical screw and conventional tension band for the fixation of transverse medial malleolar fractures
(Bayçınar Tıbbi Yayıncılık, 2019) Kuru, Tolgahan; Akpınar, Fuat; Işık, Cengiz; Özkılıç, Recai; İpek, Serdar; Mutlu, İbrahim; Kızılay, Hasan
This study aims to compare the biomechanical featuresof a new handy tension band with the malleolar screw, bicortical screwand conventional tension band for the fixation of transverse medialmalleolar fractures.Materials and methods: This study used 20 Kirschner wires,five cerclage wires, six double-hole U pins, six cortical screws, sixmalleolar screws, three malleolar clamps and one osteotomy set. Atotal of 24 tibias of two-year-old cows were obtained and stripped fromsoft tissue. Each tibia was cut with an electric saw at 15 cm proximalto the tibiotalar joint surface and the proximal tibia sections werediscarded. A transverse fracture line was created with an osteotomeon the medial malleolus. The tibias were separated into four groupswith six tibias in each group. The distal tibia medial malleolartransverse fragments were fixed under guidance of fluoroscopy withthe malleolar screw, bicortical screw, conventional tension band andthe new handy tension band.Results: In the application of both transverse and axial force, the newhandy tension band resisted higher forces in respect of catastrophicdamage force being more resistant compared to the bicortical screw,malleolar screw, and conventional tension band. However, in respectof the 2 mm displacement force of the forces applied in the axial andtransverse sections, no difference was determined between the handytension band and the other three implants.Conclusion: The new handy tension band seems to be moresuccessful when biomechanically compared with the other implants.
Osman Gazi ile İnegöl tekfurunun mücadelesi ve inegöl’ün fethi
(Özgür Türker, 2019) Güler, Cengiz
Bitinya coğrafyasında kurulan ve kısa sürede beylikten imparatorluğa dönüşen Osmanlı Devleti, tarih araştırmacılarının her zaman ilgi odağı olmuştur. Özellikle kuruluş dönemiyle ilgili birçok mesele hâlâ tartışılmaktadır. Osmanlı Devleti’nin kurucularının menşei, ilk siyasi ve askerî faaliyetleri, beyliğin siyasi olarak ortaya çıkışı gibi konular hâlâ tarihçiler arasında tartışma konusu olarak devam etmektedir. Bu konuların tam olarak açıklanamamasının nedeni Osmanlı Devleti’nin kuruluşuna dair kaynakların yetersiz olması ve bu kaynakların menkıbevi bir anlatımla yazılmış olmasındandır. Sadece sınırlı sayıdaki bu kaynaklara bağlı kalmak, kuruluş dönemi hakkındaki tartışmalara son verilmesine imkân tanımamaktadır. Bundan dolayı Halil İnalcık’ın izinden giderek bizzat sahaya inmek, coğrafyayı adım adım dolaşmak, tarihi kaynaklardaki her türlü bilgiyi coğrafya üzerinde tartışmak gerekmektedir. Bu çalışmada Osman Gazi’nin bağımsızlığını ilan etmesinden önceki faaliyetleri incelenecektir. Özellikle Osmanlı tarihçilerinin çok fazla üzerinde durmadığı İnegöl tekfurluğu ile aralarındaki ilişkiler üzerinde durulacaktır. Mevcut olan Osmanlı kroniklerindeki bilgiler tekrardan eleştirel bir gözle incelenip, olayların gerçekleştiği coğrafya üzerinde saha çalışması yapılarak ve daha önce yapılan saha çalışmalarından elde edilen veriler de kullanılarak toponomik veriler ışığında Osman Gazi’nin İnegöl tekfurluğu ile mücadeleleri ele alınacaktır.
A Rare Cause of Pleural Effusion: Ankylosing Spondylitis
(Hacettepe Üniversitesi, 2018) Sertçelik, Ümran Özden; Korkmaz, Elif Tuğçe; Babaoğlu, Elif; Sarınç Ulaşlı, Sevinç; Köksal, Deniz; Emri, Salih
Ankylosing spondylitis (AS) is a seronegative spondyloarthropathy involving the axialskeleton and major joints. Pleuropulmonary involvement is rare manifestation of ASmostly presented as apical fibrobullous disease and pleural thickening. Herein, we re-port a rare case with right sided pleural effusion in a male patient that was determinedon a chest x-ray performed routinely before initiation of anti-TNF therapy. Pleural effusion was a lymphocytic exudate with a normal glucose level. The histopathologi-cal examination of closed pleural biopsy revealed nonspecific chronic inflammato-ry cell infiltration. The patient was followed up with etanercept treatment. One yearafter the initiation of therapy, due to persistent pleural effusion, video assisted thoracoscopic surgery was performed. Pleural biopsies were also consistent with chronic inflammation.
Comparison of hemodynamic response for intubation and propofol pain caused by lidocaine administration with infusion and tourniquet
(Medicine Science, 2016) Deniz, Mohammed; Alparslan, Mustafa Muhlis; Ak, Koray; Altan, Hatice Aysel
Propofol is one of the most widely used i.v. anesthetic agent. Nevertheless, pain following i.v. administration of propofol is an important problem in anesthesia induction. A wide range of studies have been performed related to lidocaine effects on propofol injection pain and hemodynamic response to intubation. However, effect of both situations are seldomly studied in the literature. In our study we compare lidocaine effects on propofol injection pain and hemodynamic response to intubation which is given by infusion or under tourniquet as i.v. bolus. 70 patients attended to the study are separated randomly into two groups of 35 patients. Prior to induction, lidocaine has been infused with infusion pump as to be completed in 2 minutes with concentration of 2%, total dosed 1mg/kg in infusion group (Group I, n=35). In this group, after half of the total lidocaine dose is infused (1st minute), anesthesia induction has been started by giving 40 mg propofol of 1% in 10 seconds with infusion pump. In tourniquet group (Group T, n=35) prior to induction 1mg/kg lidocaine has been given as bolus by applying tourniquet with 70 mm/Hg pressure to the arm that is established vascular access and tourniquet has been remained for 60 seconds. After opening the tourniquet, induction has been started by giving 40 mg propofol of 1% in 10 seconds with infusion pump. During induction, patient‟s consciousness was evaluated by questioning his/her name and age after administering 1/4 (VRS0), 1/2 (VRS1), and 3/4 (VRS2) of total propofol dose. Confused patients were eliminated and the sense of pain caused by propofol was evaluated in study patients. The results were recorded according to four-point categorical verbal rating scale (VRS). For groups, the pulse rates and mean arterial pressures before lidocaine administration (T0), after lidocaine (T1), immediately after intubation (T2) and 10th minute after intubation (T3) were recorded. No differences detected among the groups with regards to demographic data and side effects. (p>0.05). No significant differences statically detected when comparing the heart rate (HR), mean arterial pressure (MAP) and pain scores of groups for all times (p>0.05).
What is the Diagnostic Value of Computed Tomography in Pre-school Children with Minor Head Injuries
(Galenos Yayınevi, 2023) Üçler, Necati; Özen, Ersin; Fesli, Ramazan; Taşkıran, Niyazi
In this study, we evaluated whether computed tomography (CT) examination would be required or not, based on complaints and findings after minor head trauma in pre-school children. Methods: In our retrospective study, the history of pre-school patients with minor head trauma, physical examination findings, Glasgow coma scale, cranial radiography, CT findings, and injury were evaluated retrospectively. The duration of unconsciousness and amnesia, presence of post-traumatic seizure, history of vomiting, and presence of scalp injury/hematoma were examined in the patient’s records. Clinical and radiological information was obtained retrospectively, and patients were re-evaluated one year later by phone. The fractures, edema, contusion, pneumocephalus, epidural hematoma, subdural hematoma, intraparenchymal hematoma, and intraventricular hemorrhage were evaluated on CT examination. Results: Between May 2014 and May 2018, 884 patients under 7 years of age with minor head injuries were evaluated in the emergency department. Among these, anterior-posterior and lateral cranial radiography and CT were performed in 262 patients. None of the patients had neurological deficits. Scalp laceration/ hematoma was detected in 36 (16%) patients. Fifty-two (24%) patients vomited once, whereas 12 (5%) and 5 (2%) vomited twice and thrice, respectively. A loss of consciousness (LOC) duration of <5 min was observed in 25 (11%) patients. None of the patients had a history of LOC duration of more than 5 min. However, all three patients with skull fracture had a history of LOC. Conclusion: We believe that clinical examination and other imaging methods may reduce the need for CT evaluation in pre-school childhood patients with minor head trauma.
Are the correlation results of HPV positive cases with cervical smear always consistent
(MediHealth Academy Yayıncılık, 2023) Zergeroğlu, Sema; Özkan, Zehra Sema; Aydın, Arzu Hazal
Cervical cancer is a type of genital cancer which come second after breast cancer in women and may cause death. However, it can be prevented with screening tests by ensuring early diagnosis. Most of cervical cancers (99.7%) are associated with Human Papilloma Virus (HPV) and it is known that HPV must be present for the generation of cervical cancer. Thus, 70% of the patients have been found to be positive for HPV-16 and HPV-18. Both the association with cervical cancer and HPV and data related to development of cancer and dysplasia was researched retrospectively in this study. It was aimed to analyze and use the results by examine if the smear results of the patients and the HPV results are compatible in all HPV positive cases. Material and Method: 1050 patients who were examined by gynecologist and taken Pap smear test at the end of the examination during July 2020 and March 2022, were included in our study. In all cases the Pap test was re-evaluated by the same pathologist using the 2014 Bethesda System. High-risk HPV (HR HPV) DNA (HPV types 16,18,31,33,35,39,45,51,52,56,58,59,66,68) tests results, applied to the patients at an external center, were reviewed. Results of patients diagnosed as LSIL, HSIL and cervical cancer by Pap smear test were evaluated again beside HPV DNA analyses and their clinical information. Chi-square test was used for statistical analysis.
Kitlesel Çevrimiçi Ders Platformlarında Yapılan Yorumların Metin Madenciliği Kullanılarak Duygu Analizinin Yapılması
(Kirikkale University, 2023) Daşgın, Ramazan; Adem, Kemal
Çağımızda kolay ulaşılabilen, az maliyetli, zaman mekan kısıtı olmayan şeyler daha çok ilgi görmektedir. Son zamanlarda insanların sahip olduğu olanaklar ve teknolojinin gelişimi de düşünüldüğünde insanların ilgisinde yaşanan bu değişiklik eğitime de yansımıştır. İnsanlar artık istedikleri zaman, istedikleri yerden, kendi seçebilecekleri içeriklere ulaşmak istemektedirler. Bu istekler sonunda Kitlesel Açık Çevrimiçi Ders (KAÇD) platformları ortaya çıkmaya başlamıştır. Bu platformlar üzerinde ücretli veya ücretsiz birçok konuda kurslar yer almaktadır. Birçok kişi bu kurslara kayıt olmadan önce, kurslara yapılan yorumlara ve kursa verilen puana göre değerlendirme yapılarak kayıt olmaktadırlar. Ancak tüm yorumları okuyarak bir kurs hakkında karar vermek kolay olmamaktadır. Bu çalışmada kullanıcıların yorumları okumasına gerek kalmadan kursları olumlu olumsuz olarak değerlendirmesi amacıyla KAÇD platformlarından birisi olan Udemy sitesinde bulunan kurslara yapılan yorumlar kullanılmıştır. Bu yorumlar üzerinden klasik makine öğrenmesi ve derin öğrenme kullanarak kurslar hakkında olumlu olumsuz değerlendirmeleri yapılmıştır. Klasik makine öğrenmelerinden BayesNet, J48 ve OneR algoritmaları ile en başarılı sonuç %91.576 doğruluk ile BayesNet algoritmasından elde edilmiştir. Veri setine Random, GloVe ve Word2Vec kelime gömmeleri uygulandıktan sonra, derin öğrenme modellerinden GRU ve CNN-LSTM hibrit mimarileri uygulanmış ve en başarılı sonuç GloVe Kelime gömmesi kullanıldıktan sonra %95.67 doğruluk oranıyla GRU mimarisinden elde edilmiştir.
1918'de Osmanlı'nın Azerbaycan'a askeri yardımı: stratejik hedefler ve bölgesel etkiler
(Bekir Kocadaş, 2024) İme, Gamze
Azerbaycan, 28 Mayıs 1918'de bağımsızlığını ilan ettikten sonra, Fethali Han Hoyski başkanlığında ilk milli hükümetini kurmuştur. Ülkenin ekonomik durumunu düzeltmek ve mali yapısını iyileştirmek için Osmanlı Devleti'nden destek arayışına girmiştir. Azerbaycan, mali destek ve borç para talep etmiştir. İstanbul’a gönderilen heyetler aracılığıyla gerçekleştirilen görüşmeler sonucunda, iki antlaşma yapılmıştır; ilki ticari mal alımına dair dokuz maddeden oluşurken, ikincisi 500 bin lira borç ile ilgilidir. Osmanlı’nın ekonomik desteği, Azerbaycan’da istikrarın sağlanmasına yardımcı olmuş, Türk ordusu da asayişin sağlanmasında kritik bir rol üstlenmiştir. Bu süreçte yerel halkın güvenliği, gıda arzının iyileştirilmesi ve yüksek fiyatların önlenmesi gibi konularda önemli adımlar atılmıştır. Azerbaycan, Osmanlı tecrübesinden faydalanarak kurumsal yapısını yeniden düzenlemiş ve eğitim alanında Osmanlı'dan öğretmen talep etmiştir. Osmanlı Devleti, ayrıca Azerbaycan’ın ulaşım, haberleşme ve güvenlik gibi alanlarda gelişmesine destek sağlamıştır; askeri demiryollarının modernizasyonu ve posta hizmetlerinin kurulması gibi konular bu yardımlarla ilerlemiştir. Bu yardımlar, Azerbaycan’ın uluslararası alanda tanınması ve gelişimi için kritik bir önem taşımaktadır. Bu çalışmada, Azerbaycan’ın 28 Mayıs 1918’de bağımsızlığını ilan etmesinin ardından Osmanlı Devleti’nden aldığı mali ve teknik yardımlar, Türk ordusunun sağladığı güvenlik katkıları, eğitim alanındaki destekler ve altyapı geliştirmeleri ele alınarak, bu süreçlerin Azerbaycan’ın ekonomik istikrarı ve uluslararası tanınması üzerindeki etkileri incelenecektir.
Diagnostic accuracy of fat pad sign, X-ray, and computed tomography in elbow trauma: implications for treatment choices-a retrospective study
(PeerJ, 2025) Afacan, Mustafa Ahmet; Kılıç, Koray Kaya; Temiz, Aytun; Tayfur, Ismail; Doğanay, Fatih
Introduction. Identifying skeletal injuries significantly impacts patient outcomes in trauma cases. This study aims to compare the diagnostic accuracy of X-ray (XR) and computed tomography (CT) in detecting elbow fractures among patients presenting at the emergency department (ED). Additionally, the study assesses the potential contribution of the fat pad sign to enhancing the diagnostic accuracy of XR images in identifying elbow fractures. The secondary aim focused on evaluating the precision of XR imaging in determining the necessity for surgical intervention among patients presenting with elbow trauma. Methods. Conducted retrospectively at an ED within a secondary hospital, this study included patients with elbow trauma between January 1, 2017, and January 1, 2020, who underwent both XR and CT imaging of the elbow joint. Following the application of exclusion criteria, the analysis comprised 183 patients based on remaining image data. Results. When comparing XR to CT for fracture detection, XR exhibited a sensitivity of 46.9%, specificity of 85.9%, positive predictive value (PPV) of 79.3%, negative predictive value (NPV) of 58.4%, area under the curve (AUC) of 0.664. Considering the fat pad sign in XR as a fracture indicator, the sensitivity is 60.2%, specificity is 81.2%, PPV is 78.7%, NPV is 63.9% and AUC is 0.707. A significant difference was found when comparing the AUCs obtained with and without considering the fat pad sign (p = 0.039). Regarding surgical treatment decision-making, XR showed a sensitivity of 50%, specificity of 100%, PPV of 95%, NPV of 100%, and an AUC of 0.750 when compared to CT. Conclusion. The findings indicate that XR alone is insufficient for detecting elbow fractures and determining the need for surgical treatment. Incorporating the fat pad sign improves the diagnostic accuracy of XR. In cases where suspicion of fracture is high, considering CT imaging is crucial to avoid missed diagnoses, prevent complications, and guide treatment decisions effectively.
Psychometric validation and measurement invariance of the self-compassion scaleshort form (SCS-SF) across gender, clinical population, and cultures
(Springer Nature, 2025) Büyüköksüz, Engin; Tekin, Işıl; Arıkan, Serkan; İlkay, Şengül; Erözkan, Atılgan
Background The concept of self-compassion, rooted in Eastern philosophies, is closely related to psychological wellbeing and is considered a key skill in alleviating psychological disorders. The short form (SCS-SF) of Self-Compassion Scale was developed and used by many scholars. The current study aimed to conduct an adaptation study of the SCS-SF in Turkish and to analyze its psychometric properties in clinical and non-clinical samples. Methods In the adaptation process, the confirmatory factor analysis (CFA) for the general population (n=545) and clinical population (n=246) was conducted. We also investigated evidence for convergent validity (n=274) and conducted a test-retest reliability study with a sample of 53 participants. Additionally, we evaluated the measurement invariance of the SCS-SF across different gender groups, clinical versus non-clinical samples, and cross-cultural samples (comparing Türkiye and the USA, with a sample size of 125 in the USA). Results Confirmatory factor analysis showed a six-factor model for the non-clinical sample, yielding fit indices of TLI=0.920, CFI=0.953, and RMSEA=0.095. Also, the six-factor model exhibited a good fit for the clinical sample, with TLI=0.968, CFI=0.981, and RMSEA=0.045. Reliability analysis indicated Cronbach’s alpha values were between 0.77 and 0.88, alongside a strong test-retest reliability coefficient of r=0.878 (p<0.001). Furthermore, measurement invariance was confirmed across clinical and non-clinical groups, as well as across gender groups and among Turkish and American cultural contexts, thereby affirming the scale’s applicability across varied populations. Conclusion The adapted SCS-SF scores demonstrated good reliability. The CFA showed a six-dimensional structure and there was evidence for convergent validity and measurement invariance across gender groups as well as between samples from the USA and Türkiye. Consequently, the current study indicates that the adaptation was successful, and the Turkish version can be used for both clinical and non-clinical samples. However, limitations include the reliance on self-report measures and potential cultural bias in the interpretation of self-compassion constructs.
Redox balance in dairy cattle and their calves at birth and its relationship to colostral passive immunity
(Hellenic Veterinary Medical Society, 2025) Gökçe, E.; Cihan, P.; Kuru, M.; Atakişi Onur; Erkılıç, Ekin Emre; Makav, M.; Erdoğan, H.M.
Newborn calves are exposed to oxidative stress (OS) just after birth, and yet the role of colostrum in OS is not well detailed. The redox indicators, total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)] along with immunoglobulin-G (IgG) concentrations were assessed in 21 healthy Swiss Brown mother-calf pairs. Furthermore, alterations in theseparameters and IgG concentrations were analysed in an additional 23 healthy calves during the first 45 days of life (day 0 = at birth, 1, 3, 7, 14, 28 and 45). TAS and TOS concentrations were determined calorimetrically and IgG level by commercial ELISA kit. A negative correlation was determined between colostral IgG and serum maternal TOS (r:-0.49, P<0.05) and colostral TAS (r:-0.54, P <0.05). Calves exhibited elevated levels of TOS (8.29±0.30), TAS (0.71 ± 0.02) and OSi (1.20 ± 0.08) at birth. However these levels decreased after the 24th hour (6.72 ±0.2, 0.65 ±0.03, and 1.05 ±0.05, respectively) and remained stable throught the study. In conclusion, our results suggest that newborn calves experience OS after birth and colostral antioxidants may highlights its potential role in mitigating OS in these calves. The results may be of help in improving antioxidant capacity, either by treating dams during pregnancy or by treating colostrum with substances with antioxidant properties.
Optimal graft choices for tibial plateau fractures with joint depression
(Turkish Joint Diseases Foundation, 2025) Öktem, Umut; Uysal, Özgur Selim; Dastan, Muhammed Cihan; Bulut, Mustafa; Bozkurt, İbrahim; Bingöl, İzzet; Öçgüder, Durmuş Ali
This study aims to provide insight into the advantages and disadvantages of autograft and synthetic graft use in the surgical treatment of tibial plateau fractures with joint depression by comparing the clinical and radiological outcomes of both graft types. Patients and methods: Between February 2019 and September 2022, a total of 51 patients (23 males, 28 females; mean age: 45.3±13.5 years; range, 20 to 69 years) who underwent surgical treatment for Schatzker type 2 and type 3 tibial plateau fractures in our clinic were retrospectively analyzed. The patients were divided into two groups; 30 patients received autografts and 21 received tricalcium phosphate synthetic grafts. Demographic data, graft type, fracture classification, preoperative joint depression, body mass index (BMI), and smoking status were recorded. Postoperative evaluations included Lysholm and Visual Analog Scale (VAS) scores at two years.
Effects of coadministration of foot and mouth disease vaccine and inactivated parapoxvirus ovis on humoral immunity in cattle
(Polska Akademia Nauk, 2025) Canbar, R.; Uslu, M.
Foot and mouth disease (FMD) is an acute viral disease in animals. Inactive parapoxvirus ovis (IPPVO) strengthens humoral immunity. This study aimed to determine the effect of IPPVO application together with FMD vaccine on cattle immunity. It included 30 Holstein cattle randomly divided into two groups: one was administered only the FMD vaccine, and the other was administered the FMD vaccine and IPPVO simultaneously. Control blood was collected from all animals at 0 hours. Serum TNF-α, IL-1β, and IL-6 levels were measured in blood samples collected at 4, 8, 12, 16, and 24 hours post-vaccination, while serum IgG and IgM levels were measured in blood samples collected at 4, 8, 12, 16, and 20 days post-vaccination using ELISA kits. While no changes in serum TNF-α, IL-1β, and IL-6 levels were detected in the FMD group, IL-1β levels significantly increased (peaking at four hours) in the FMD + IPPVO group. In the FMD group, while IgG levels increased significantly (peaking at 16 days), IgM levels did not change. In the FMD + IPPVO group, IgG level on day 8 days was higher than the 16 days value. Also, the IgM level increased significantly on day 16. In conclusion, the application of FMD with IPPVO increases the primary immune response (IgM), but it does not effect the long-term immune response (IgM).
Evaluation of the necessity of simultaneous cholecystectomy in patients undergoing liver hydatid cyst surgery
(Elsevier B.V., 2025) Martlı, Hüseyin Fahri; Aydın, Arzu Hazal; Şahingöz, Eda; Duru, Derviş; Er, Sadettin; Turhan, Nesrin; Tez, Mesut
Liver hydatid cysts remain a significant public health issue in Turkey, the Middle East, East Asia, and Russia. Surgical treatments are often employed for certain stages of this disease. However, the necessity of simultaneous cholecystectomy during these procedures remains unclear. Treating symptoms related to subsequent cholelithiasis can become more challenging. This study investigates the necessity of simultaneous cholecystectomy by following patients who underwent hydatid cyst surgery with or without concurrent cholecystectomy. Materials and methods: Patients who underwent surgery for hydatid cysts between 2019 and 2024 at the General Surgery Clinic of Ankara Bilkent City Hospital were retrospectively reviewed. A total of 97 patients were included, with 56 (54.32 %) undergoing cholecystectomy along with hydatid cyst surgery (Group 1) and 41 (45.68 %) not undergoing cholecystectomy (Group 2). Preoperative clinical, laboratory, and radiological findings, as well as intraoperative data, morbidity, mortality, and postoperative symptoms, were analyzed. Results: Patients in Group 1 had longer hospital stays, higher blood loss, and significantly higher Clavien-Dindo complication scores. In the postoperative follow-up of Group 2, 8 patients (19.51 %) developed stones or sludge, and 1 patient (2.4 %) developed polyps. Four patients (9.75 %) presented to the emergency department with cholecystitis symptoms. A total of 5 patients (12.19 %), including 4 with symptomatic cholelithiasis (9.7 %) and 1 with gallbladder polyps (2.4 %), underwent elective cholecystectomy. Two (40 %) of these cholecystectomies were performed laparoscopically, while three (60 %) were converted to open cholecystectomy. Conclusion: Simultaneous cholecystectomy during liver hydatid cyst surgery may prevent difficulties associated with treating symptoms related to subsequent cholelithiasis.
Effects of Dietary Anise (Pimpinella anisum L.) Oil on Growth Performance, Blood Parameters and Muscle Nutrient Content of Nile Tilapia (Oreochromis niloticus)
(John Wiley and Sons Inc, 2025) Tok, Serkan; Öz, Mustafa; Dikel, Suat
Objectives: This study aimed to investigate the effects of dietary Pimpinella anisum (anise) oil supplementation on growth performance, haematological and biochemical parameters, antioxidant enzyme activities and tissue histopathology in Nile tilapia (Oreochromis niloticus). The goal was to determine the optimal inclusion level that promotes health benefits without inducing toxicity. Methodology: A total of 240 juvenile Nile tilapia were randomly distributed into four groups: control (0.00%) and three treatments receiving anise oil at 0.10%, 0.20% and 0.30% for 8 weeks. Growth performance (weight gain, feed conversion ratio), haematological (RBC, Hb, WBC) and biochemical parameters (ALT, AST, glucose, lipids), oxidative stress markers (SOD, CAT, GPx) and histopathological changes in gill, liver, kidney and muscle tissues were evaluated. Results: Anise oil supplementation at 0.10% and 0.20% significantly improved growth performance, haematological indices and antioxidant enzyme activities (p < 0.05) compared to the control group. However, fish fed 0.30% anise oil showed elevated liver enzymes, glucose and lipid levels, along with moderate tissue damage, indicating potential adverse effects at higher doses. Conclusions: Dietary inclusion of 0.10% to 0.20% anise oil enhances the growth, physiological health and antioxidant defence in Nile tilapia. Nevertheless, 0.30% inclusion may impair metabolic balance and tissue integrity. Anise oil represents a promising natural feed additive for sustainable aquaculture when used at optimal levels.
The effects of hormone therapy on clinical symptoms
(Nova Science Publishers, Inc., 2024) Sezgin, Aydan
Menopause is difficult because of the clinical symptoms associated with hormonal changes. Every woman experiences these clinical symptoms to a greater or lesser extent. Hormone therapy has a particularly positive effect on vasomotor symptoms and genitourinary symptoms, but also on other symptoms. Hormone therapy consists mainly of estrogen preparations, and in women with a uterus, estrogen +progesterone preparations. There are various routes of administration of these preparations (oral, vaginal, and transdermal). However, since hormone therapy can increase the risk of cardiovascular disease, thromboembolic events, and breast cancer, the patient group to receive hormone therapy should be carefully selected.

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