Effect of retinyl acetate on transglutaminase 2 activity in carcinogen treated rat liver

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dc.contributor.authorAydın, O.
dc.contributor.authorAkyüz, F.
dc.contributor.authorTekin, N.
dc.contributor.authorÜstüner, M. C.
dc.contributor.authorDeğirmenci, I.
dc.contributor.authorBurukoğlu, D.
dc.contributor.authorÖzden, H.
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:14:57Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:14:57Z
dc.date.issued2016
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractTransglutaminase 2 (TG2) has been implicated in wound healing, cellular differentiation, apoptosis and cell survival. TG2 activity increases following acute and chronic liver injury; however, the role of TG2 in tumors, is controversial. TG2 is a retinoid-inducible enzyme. We investigated the effects of retinyl acetate (RA) on the activity and levels of TG2 during the initiation and promotion stages of liver cancer. p-Dimethylaminoazobenzene (p-DAB) was used as initiator and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) was used as promoter in our model of carcinogenesis. Rats were divided into four groups of 24: control, corn oil control, p-DAB + TCDD, and p-DAB + TCDD + RA. Six rats from each group were sacrificed at days 30, 60, 90 and 120. TG2 activity decreased in the p-DAB + TCDD treated group, but TG2 immunostaining scores did not change by days 90 and 120. Neither TG2 enzyme activity nor the immunostaining score of TG2 protein changed in the tissues of the p-DAB + TCDD + RA group by days 90 and 120. TG2 activity was not be ameliorated by RA during the initiation or promotion stages of carcinogen induced liver cancer.
dc.description.sponsorshipResearch Foundation of Eskisehir Osmangazi University, Turkey [200811016]
dc.description.sponsorshipOur study was supported by Grant no. 200811016 from the Research Foundation of Eskisehir Osmangazi University, Turkey.
dc.identifier.doi10.3109/10520295.2016.1170879
dc.identifier.endpage351en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid27089473
dc.identifier.scopusqualityQ2
dc.identifier.startpage342en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2016.1170879
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4226
dc.identifier.volume91en_US
dc.identifier.wosWOS:000379664700004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofBiotechnic & Histochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCarcinogen
dc.subjectLiver
dc.subjectRat
dc.subjectRetinyl Acetate
dc.subjectTransglutaminase 2
dc.titleEffect of retinyl acetate on transglutaminase 2 activity in carcinogen treated rat liver
dc.typeArticle

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