Protective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach

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dc.contributor.authorŞimşek, Hasan
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorGür, Cihan
dc.contributor.authorİleritürk, Mustafa
dc.contributor.authorAygörmez, Serpil
dc.contributor.authorKandemir, Fatih Mehmet
dc.date.accessioned2023-09-28T06:31:36Z
dc.date.available2023-09-28T06:31:36Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractSodium arsenite (SA) exposure is toxic to the body. Zingerone (ZNG) is a flavonoid with many biological properties found naturally in honey and plants. This study aimed to determine the effects of ZNG on SA-induced rat lung toxicity. Materials and Methods: Thirty-five male Sprague rats were divided into Control, SA, ZNG, SA+ZNG25, and SA+ZNG50 groups (n=7). SA 10 mg/kg and ZNG were administered at two doses (25 and 50 mg/kg) (orally, 14 days). Analysis of oxidative stress, inflammation damage, apoptosis damage, and autophagic damage markers in lung tissue were determined by biochemical and histological methods. Results: The administration of ZNG reduced oxidative stress by increasing SA-induced decreased antioxidant enzyme activities, increasing Nrf-2, HO-1, and NQO1, and decreasing MDA level. ZNG administration reduced inflammation marker levels. Anti-apoptotic Bcl-2 increased and apoptotic Bax and Caspase-3 decreased with ZNG. ZNG promoted the regression of autophagy by reducing Beclin-1, LC3A, and LC3B levels. Conclusion: Evaluating all data showed that SA caused toxic damage to lung tissue by increasing inflammation, apoptosis, autophagy, and oxidant levels, whereas ZNG had a protective effect by reducing this damage.
dc.identifier.doi10.22038/IJBMS.2023.71905.15623
dc.identifier.endpage1106en_US
dc.identifier.issn2008-3866
dc.identifier.issue9en_US
dc.identifier.pmid37605724
dc.identifier.scopusqualityQ2
dc.identifier.startpage1098en_US
dc.identifier.urihttps:/dx.doi.org10.22038/IJBMS.2023.71905.15623
dc.identifier.urihttps://hdl.handle.net/20.500.12451/10994
dc.identifier.volume26en_US
dc.identifier.wosWOS:001041104000015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad University of Medical Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectApoptosis
dc.subjectAutophagy
dc.subjectInflammation
dc.subjectLung
dc.subjectOxidative Stress
dc.subjectSodium Arsenite
dc.subjectToxicity
dc.subjectZingerone
dc.titleProtective effects of zingerone against sodium arsenite-induced lung toxicity: A multi-biomarker approach
dc.typeArticle

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