The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin
| dc.authorid | 0000-0003-2457-3367 | |
| dc.authorid | 0000-0002-8490-2479 | |
| dc.contributor.author | Akdemir, Fazile Nur Ekinci | |
| dc.contributor.author | Yıldırım, Serkan | |
| dc.contributor.author | Kandemir, Fatih Mehmet | |
| dc.date.accessioned | 2022-08-29T07:36:07Z | |
| dc.date.available | 2022-08-29T07:36:07Z | |
| dc.date.issued | 2022 | |
| dc.department | Tıp Fakültesi | |
| dc.description.abstract | In this, it was aimed to determine the possible beneficial effects of evodiamine on hepatotoxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups (n=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS), and evodiamine+cisplatin (EVO+CIS) groups. All experimental processes were applied according to rules of ethical. Rats were sacrificed by high-dose anesthesia. Considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in the EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-? expressions were severe in the CIS group, whereas, in the EVO+CIS group, these expressions attenuated. | |
| dc.identifier.doi | 10.1007/s11356-022-22007-x | |
| dc.identifier.endpage | - | en_US |
| dc.identifier.issn | 0944-1344 | |
| dc.identifier.issue | - | en_US |
| dc.identifier.pmid | 35854071 | |
| dc.identifier.scopusquality | Q1 | |
| dc.identifier.startpage | - | en_US |
| dc.identifier.uri | https:/dx.doi.org/10.1007/s11356-022-22007-x | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12451/9648 | |
| dc.identifier.volume | - | en_US |
| dc.identifier.wos | WOS:000827389600005 | |
| dc.identifier.wosquality | Q1 | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Springer Science and Business Media Deutschland GmbH | |
| dc.relation.ispartof | Environmental Science and Pollution Research | |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Apoptosis | |
| dc.subject | Cisplatin | |
| dc.subject | Evodiamine | |
| dc.subject | Liver Toxicity | |
| dc.subject | Oxidative stress | |
| dc.title | The possible beneficial impacts of evodiamine on hepatotoxicity induced by cisplatin | |
| dc.type | Article |
