Adrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats

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dc.authoridFen Bilgisi Egitimi, Aksaray Egitim -- 0000-0001-8976-571X; Yurekli, Muhittin -- 0000-0002-5830-8564
dc.contributor.authorYürekli, Muhittin
dc.contributor.authorEşrefoğlu, Mukeddes
dc.contributor.authorDoğru, Mehmet İlker
dc.contributor.authorDoğru, Arzu
dc.contributor.authorGül, Mehmet Ali
dc.contributor.authorWhidden, Melissa A.
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:26:41Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:26:41Z
dc.date.issued2009
dc.departmentSabire Yazıcı Fen Edebiyat Fakültesi
dc.description.abstractAdrenomedullin (AdM) is synthesized and secreted by a number of cells and tissue. AdM is a potent vasodilator but it is also considered a neuromodulator, an angiogenic factor, and a hormone regulator. AdM possess antiapoptotic, antioxidant, and antimicrobial properties. Heavy metals such as cadmium and lead are found widely in the environment and they have important biological functions. Lead (Pb) and cadmium (Cd) can accumulate in the lungs, liver, bone, and kidneys and cause serious organ damage. In the present study, we investigated the effect of AdM, Pb + AdM, and Cd + AdM treatments on superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as the level of malondialdehyde (MDA) in the kidney. Heavy metal accumulation was determined in kidney with and without AdM infusion and kidney damage was evaluated by light and electron microscopy. Increased heavy metal accumulation was observed in the heavy metal and AdM treated groups. SOD, CAT, GSH-Px activities, and MDA levels were significantly different in the treatment groups when compared with the control group. Tubular degeneration, necrosis, cell swelling, mononuclear cell infiltration, and degenerated organelles were observed in the kidney following treatment. Therefore, AdM infusion has no beneficial and/or compensatory role in cadmium and lead toxicity in the kidney. We conclude that heavy metal accumulation in the kidney in conjunction with AdM infusion is cytotoxic despite the known beneficial effects of adrenomedullin. (C) 2008 Wiley Periodicals, Inc. Environ Toxicol 24: 279-286, 2009.
dc.identifier.doi10.1002/tox.20430
dc.identifier.endpage286en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue3en_US
dc.identifier.pmid18655190
dc.identifier.scopusqualityQ1
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.1002/tox.20430
dc.identifier.urihttps://hdl.handle.net/20.500.12451/5678
dc.identifier.volume24en_US
dc.identifier.wosWOS:000265967200008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWıley-Blackwell
dc.relation.ispartofEnvironmental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdrenomedullin
dc.subjectSOD
dc.subjectCAT
dc.subjectGSH-Px
dc.subjectLight and Electron Microscopy
dc.subjectHeavy Metals
dc.titleAdrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats
dc.typeArticle

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