New histopathological evidence for the relationship between hydromyelia and hydrocephalus following subarachnoid hemorrhage: An experimental study

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dc.contributor.authorYardım, Ahmet
dc.contributor.authorKanat, Ayhan
dc.contributor.authorKaradağ, Mehmet Kürşat
dc.contributor.authorAydın, Mehmet Dumlu
dc.contributor.authorGel, Mehmet Selim
dc.contributor.authorDaltaban, İskender Samet
dc.contributor.authorDemirtaş, Rabia
dc.date.accessioned2023-10-24T11:44:50Z
dc.date.available2023-10-24T11:44:50Z
dc.date.issued2023
dc.departmentTıp Fakültesi
dc.description.abstractObjectives: Subarachnoid hemorrhage (SAH) is a serious pathology with a high death and morbidity rate. There can be a relationship between hydromyelia and hydrocephalus following SAH; however, this subject has not been well investigated. Materials and methods: Twenty-four rabbits (3 ± 0.4 years old; 4.4 ± 0.5 kg) were used in this study. Five of them were used as the control, and five of them as the SHAM group. The remaining animals (n = 14) had been used as the study group. The central canal volume values at the C1-C2 levels, ependymal cells, numbers of central canal surfaces, and Evans index values of the lateral ventricles were assessed and compared. Results: Choroid plexus edema and increased water vesicles were observed in animals with central canal dilatation. The Evans index of the brain ventricles was 0.33 ± 0.05, the mean volume of the central canal was 1.431 ± 0.043 mm3, and ependymal cells density was 5.420 ± 879/mm2 in the control group animals (n = 5); 0.35 ± 0.17, 1.190 ± 0.114 mm3, and 4.135 ± 612/mm2 in the SHAM group animals (n = 5); and 0.44 ± 0.68, 1.814 ± 0.139 mm3, and 2.512 ± 11/mm2 in the study group (n = 14). The relationship between the Evans index values, the central canal volumes, and degenerated ependymal cell densities was statistically significant (P < 0.05). Conclusions: This study showed that hydromyelia occurs following SAH-induced experimental hydrocephalus. Desquamation of ependymal cells and increased cerebrospinal fluid secretion may be responsible factors in the development of hydromyelia.
dc.identifier.doi10.4103/jcvjs.jcvjs_67_23
dc.identifier.endpage258en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage253en_US
dc.identifier.urihttps:/dx.doi.org10.4103/jcvjs.jcvjs_67_23
dc.identifier.urihttps://hdl.handle.net/20.500.12451/11220
dc.identifier.volume14en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPMC
dc.relation.ispartofJournal of Craniovertebral Junction & Spine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydrocephalus
dc.subjectHydromyelia
dc.subjectIntraventricular Hemorrhage
dc.subjectSubarachnoid Hemorrhage
dc.titleNew histopathological evidence for the relationship between hydromyelia and hydrocephalus following subarachnoid hemorrhage: An experimental study
dc.typeArticle

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