Does Zn-Mediated regulation of the Kynurenine Pathway provide the link between periodontal disease and diabetes

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dc.contributor.authorAfşar, Ebru
dc.contributor.authorDoğan, Kadirhan
dc.contributor.authorArslan, Erdem
dc.contributor.authorEranil, Işıl
dc.contributor.authorOral, Neşe
dc.contributor.authorKuzzu, Kadir Bahadır
dc.contributor.authorCeylan, Tayfun
dc.contributor.authorÖz, Mehmet
dc.date.accessioned2025-09-19T11:30:53Z
dc.date.available2025-09-19T11:30:53Z
dc.date.issued2025
dc.departmentTıp Fakültesi
dc.description.abstractIt has long been known that there is a relationship between periodontal diseases and diabetes. The present study aimed to assess the effect of pancreatic zinc (Zn) levels on Kynurenin pathways (KP) and glucose homeostasis and the impact of Thymoquinone (TQ) in the periodontal disease animal model. Ten microliters of Porphyromonas gingivalis-lipopolysaccharide (P. gingivalis-Lps) (1 mg/ml) was injected at 48-h intervals into the palatal gingiva of rats, and TQ was given by oral gavage (10 mg/kg per day) for 2 weeks. Glucose homeostasis was assessed using the Homeostatic Model Assessment (HOMA-IR), and β-cell function (HOMA-β Levels). Kynurenine (KYN), Tryptophan (TRP), kynurenic acid (KYNA), quinolinic acid (QA), KYN 3-monooxygenase (KMO), kynureninase, interferon-γ (IFN-γ), insulin, ZIP10, and caspase-3 levels measured by the enzyme-linked immunosorbent assay (ELISA). Zinc levels in the pancreas tissue and plasma samples were measured using a colorimetric method. Morphological changes in the pancreas were identified by hematoxylin and eosin staining, and X-ray radiography determined bone resorption in the maxillary bone. In the LPS group, pancreas ZIP10 and Zn levels increased, the KP pathway was altered to favor KYNA, and impaired glucose homeostasis was observed. TQ administration decreased pancreatic Zn levels, changed KP to favor QA, and improved morphological changes in the pancreas. During the progression of periodontal diseases, KP may be altered by Zn levels through ZIP10 in the pancreas, thereby impairing pancreatic function. Regulation of Zn levels may be key to shared pathways between periodontal diseases and diabetes.
dc.identifier.doi10.1007/s12011-025-04776-x
dc.identifier.issn01634984
dc.identifier.scopus2-s2.0-105012756739
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s12011-025-04776-x
dc.identifier.urihttps://hdl.handle.net/20.500.12451/14507
dc.identifier.wosWOS:001546009800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.institutionauthorArslan, Erdem
dc.institutionauthorÖz, Mehmet
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiabetes
dc.subjectKynurenine
dc.subjectPorphyromonas Gingivalis
dc.subjectThymoquinone
dc.subjectZinc
dc.titleDoes Zn-Mediated regulation of the Kynurenine Pathway provide the link between periodontal disease and diabetes
dc.typeArticle

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