Molecularly imprinted cryogel membranes for mitomycin C delivery

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dc.authoridCetin, Kemal -- 0000-0002-7393-7377; TOPCU, Aykut Arif -- 0000-0002-5434-4920
dc.contributor.authorÖncel, Pınar
dc.contributor.authorÇetin, Kemal
dc.contributor.authorTopçu, Aykut Arif
dc.contributor.authorYavuz, Handan
dc.contributor.authorDenizli, Adil
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-29T19:28:48Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-29T19:28:48Z
dc.date.issued2017
dc.departmentFen-Edebiyat Fakültesi
dc.description.abstractIn this study, cryogel-based implantable molecularly imprinted drug delivery systems were designed for the delivery of antineoplastic agent. Mitomycin C imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-l-glutamic acid) cryogel membranes were produced by free-radical bulk polymerization under partially frozen conditions. The membranes were characterized by swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, surface area measurements and in vitro hemocompatibility tests. In vitro delivery studies were carried out to examine the effects of cross-linker ratio and template content. Mitomycin C imprinted cryogel membranes have megaporous structure (10-100 mu m in diameter). The cumulative release of mitomycin C was decreased with increasing cross-linking agent ratio and increased with the amount of template in the cryogel structure. The nature of transport mechanism of the mitomycin C from the membranes was non-Fickian.
dc.description.sponsorshipTUBITAK-BIDEB2211-National Ph.D. Scholarship Programme
dc.description.sponsorshipKemal Cetin thanks The Scientific and Technological Research Council of Turkey (TUBITAK) for the support by 'TUBITAK-BIDEB2211-National Ph.D. Scholarship Programme'.
dc.identifier.doi10.1080/09205063.2017.1282772
dc.identifier.endpage531en_US
dc.identifier.issn0920-5063
dc.identifier.issn1568-5624
dc.identifier.issue6en_US
dc.identifier.pmid28105892
dc.identifier.scopusqualityQ1
dc.identifier.startpage519en_US
dc.identifier.urihttps://doi.org/10.1080/09205063.2017.1282772
dc.identifier.urihttps://hdl.handle.net/20.500.12451/6087
dc.identifier.volume28en_US
dc.identifier.wosWOS:000399567500002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS
dc.relation.ispartofJOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCryogel Membrane
dc.subjectMitomycin C Delivery
dc.subjectMolecular Imprinting
dc.titleMolecularly imprinted cryogel membranes for mitomycin C delivery
dc.typeArticle

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