Ankaferd Blood Stopper with antibiofilm potential successfully inhibits the extracellular matrix degradation enzymes and promotes wound healing of 3T3 fibroblasts in vitro

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dc.contributor.authorBoran, Rukiye
dc.contributor.authorBaygar, Tuba
dc.contributor.authorSaraç, Nurdan
dc.contributor.authorUğur, Aysel
dc.date.accessioned13.07.201910:50:10
dc.date.accessioned2019-07-16T09:15:19Z
dc.date.available13.07.201910:50:10
dc.date.available2019-07-16T09:15:19Z
dc.date.issued2018
dc.departmentSağlık Hizmetleri Meslek Yüksekokulu
dc.description.abstractBackground/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method. Results: At 10% ABS successfully inhibited the biofilm formation of the tested microorganisms. Enzyme inhibition analysis revealed that 3% ABS significantly inhibited all three enzymes related to wound healing. The scratch assay showed that wound closure was faster than that of the control for the 3% ABS/plate. Conclusion: The findings of the present study indicated that ABS has effective wound healing potential with its strong antibiofilm activity against oral cavity microorganisms.
dc.identifier.doi10.3906/sag-1712-80
dc.identifier.endpage634en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid29916223
dc.identifier.scopusqualityQ1
dc.identifier.startpage627en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1712-80
dc.identifier.urihttps://hdl.handle.net/20.500.12451/4350
dc.identifier.volume48en_US
dc.identifier.wosWOS:000435653900026
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnkaferd Blood Stopper
dc.subjectEnzyme Inhibition
dc.subjectAntibiofilm
dc.subjectWound Healing
dc.titleAnkaferd Blood Stopper with antibiofilm potential successfully inhibits the extracellular matrix degradation enzymes and promotes wound healing of 3T3 fibroblasts in vitro
dc.typeArticle

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